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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significantly reduce » significantly reduced (Expand Search), significantly greater (Expand Search), significantly enhance (Expand Search)
reduce decrease » reduce disease (Expand Search), reduce depressive (Expand Search), induces decreased (Expand Search)
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7221
Data Sheet 1_Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells.doc
Published 2025“…Introduction<p>Pancreatic beta cells undergo metabolic remodeling in response to metabolic overload, but the functional significance of this remains unclear. 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) is a glycolytic regulator that may play a role in beta cell adaptation under acute metabolic stress. …”
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7222
Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability (Sup Tables). Berthier et al. J. Hepatol. 2025
Published 2025“…</p><h3>Results</h3><p dir="ltr">Our study shows that temporarily blocking the insulin receptor in young mice leads to later-life liver issues by hindering PPARα-mediated adaptation to a high-fat diet. This is linked to decreased histone active marks at PPARα sites and reduced endogenous PPARα ligands. …”
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7223
Image1_Characterization of GABAergic marker expression in prefrontal cortex in dexamethasone induced depression/anxiety model.jpeg
Published 2024“…Furthermore, DEX treatment reduced the expression levels of a GABA-synthesizing enzyme (GAD67), Reelin, calcium-binding proteins (parvalbumin and calretinin) and neuropeptides co-expressed in GABAergic neurons (somatostatin, neuropeptide Y and vasoactive intestinal peptide) in the PFC were reduced after 21 days of DEX treatment; these reductions were accompanied by decreases in brain size and cerebral cortex thickness.…”
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7224
Table 1_Prevalence and prognostic value of sarcopenia in patients with bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis.docx
Published 2025“…</p>Objectives<p>This study was conducted to systematically evaluate the prognostic significance of sarcopenia in patients with bladder cancer undergoing RC.…”
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7225
Table1_Effect of inflammatory cytokines and plasma metabolome on OSA: a bidirectional two- sample Mendelian randomization study and mediation analysis.pdf
Published 2024“…Furthermore, we found that the increased risk of OSA could be attributed to reduced levels of X-11849 and X-24978 (decreases of 7.1% and 8.4%, respectively). …”
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7226
Key model formula.
Published 2024“…This study underscores the significance of the COVID-19 vaccine booster policy. …”
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7227
Model framework.
Published 2024“…This study underscores the significance of the COVID-19 vaccine booster policy. …”
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7228
Essential model parameters.
Published 2024“…This study underscores the significance of the COVID-19 vaccine booster policy. …”
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7229
The Effect of Chronic Stress on Apoptosis Regulation and Oncogenesis Evolution: A Theoretical Approach.
Published 2025“…In particular, we seek to illustrate the epigenetic influence of stress on genes that control apoptosis, as well as the significance of the HPA axis as a therapeutic target for restoring cellular equilibrium. …”
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7230
Optimisation of read depth, DNA quantity, and unique alternate observation threshold.
Published 2025“…J-L: Increasing unique alternative observation (UAO) thresholds for variant calls increased detection rate of rare variants (J), but markedly decreased the number of variants passing the threshold (K) and therefore reduced detection of true positive variants in reference standards (L). …”
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7231
Additional file 2 of Single-cell profiling reveals periosteal signatures of impaired periosteal cells proliferation in a drill-hole model of type 2 diabetes
Published 2025“…Supplementary Material 2: Figure S1. Reduced bone mass in 12-week-old db/db mice. A. Body weight (left) and fasting blood glucose (right) of db/db and db/+ mice at different age. …”