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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
reduced decrease » reduced disease (Expand Search), reported decrease (Expand Search), induces decreased (Expand Search)
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5901
Table 3_Exploring the therapeutic potential of “Zhi-Zhen” formula for oxaliplatin resistance in colorectal cancer: an integrated study combining UPLC-QTOF-MS/MS, bioinformatics, ne...
Published 2025“…Additionally, β-catenin knockdown led to an upregulation of CASP7 expression, whereas activation of the Wnt/β-catenin signaling pathway reduced CASP7 protein levels. ZZF decreases the activity of the Wnt/β-catenin signaling pathway by decreasing β-catenin transcription and nuclear localization.…”
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5902
In Vivo, In Vitro, and In Silico Assessment of Anticancer Activity of the New Pincer-Type Pt(II) Complexes
Published 2025“…The in vivo findings reinforced these results, demonstrating that <b>Pt1</b> significantly reduced tumor growth while exhibiting minimal systemic toxicity. …”
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5903
DataSheet1_Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats.docx
Published 2024“…Furthermore, DPDS intervention markedly reduced the protein expression of α-SMA, COI Ⅳ, FN, and vimentin in the kidneys. …”
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5904
Image1_GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux.TIF
Published 2024“…Here, using surface biotinylation and (N-(Ethoxycarbonylmethyl)-6-Methoxyquinolinium Bromide) MQAE-dye based fluorescence quenching, we show that upregulated GABA<sub>A</sub>R are on the cell-surface in TNBC cell lines and mediate significantly higher chloride (Cl<sup>−</sup>) flux as compared to non-tumorigenic MCF10A cells. …”
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5905
Table 2_Immunomodulatory peptide–drug conjugate MEL-dKLA suppresses progression of prostate cancer by eliminating M2-like tumor-associated macrophages.docx
Published 2025“…In vivo, MEL-dKLA treatment significantly reduced tumor growth, decreased the number of CD163<sup>+</sup> M2 macrophages, and increased CD8<sup>+</sup> T cell infiltration in tumor tissues. …”
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5906
The components of Qili Qiangxin capsule.
Published 2024“…QLQX treatment for 28 days significantly improved cardiac function, as evidenced by decreases in heart mass index, cardiac volume, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, N-terminal B-type natriuretic peptide levels, and high-sensitivity cardiac troponin I levels and increases in left ventricular ejection fraction and left ventricular fraction shortening. …”
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5907
Image 1_Exploring the therapeutic potential of “Zhi-Zhen” formula for oxaliplatin resistance in colorectal cancer: an integrated study combining UPLC-QTOF-MS/MS, bioinformatics, ne...
Published 2025“…Additionally, β-catenin knockdown led to an upregulation of CASP7 expression, whereas activation of the Wnt/β-catenin signaling pathway reduced CASP7 protein levels. ZZF decreases the activity of the Wnt/β-catenin signaling pathway by decreasing β-catenin transcription and nuclear localization.…”
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5908
Table 2_Exploring the therapeutic potential of “Zhi-Zhen” formula for oxaliplatin resistance in colorectal cancer: an integrated study combining UPLC-QTOF-MS/MS, bioinformatics, ne...
Published 2025“…Additionally, β-catenin knockdown led to an upregulation of CASP7 expression, whereas activation of the Wnt/β-catenin signaling pathway reduced CASP7 protein levels. ZZF decreases the activity of the Wnt/β-catenin signaling pathway by decreasing β-catenin transcription and nuclear localization.…”
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5909
Table 1_Exploring the therapeutic potential of “Zhi-Zhen” formula for oxaliplatin resistance in colorectal cancer: an integrated study combining UPLC-QTOF-MS/MS, bioinformatics, ne...
Published 2025“…Additionally, β-catenin knockdown led to an upregulation of CASP7 expression, whereas activation of the Wnt/β-catenin signaling pathway reduced CASP7 protein levels. ZZF decreases the activity of the Wnt/β-catenin signaling pathway by decreasing β-catenin transcription and nuclear localization.…”
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5910
Table 1_Effects of compound lactic acid bacteria on the quality and microbial diversity of alfalfa silage in saline-alkali soils.xlsx
Published 2025“…The results of the microbial community showed that compared with the non-additives group, the Shannon index decreased and the Simpson index increased in the compound lactic acid bacteria group, indicating a significant reduction in microbial diversity in the silage environment (P < 0.05). …”
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5911
Data Sheet 1_Effects of compound lactic acid bacteria on the quality and microbial diversity of alfalfa silage in saline-alkali soils.zip
Published 2025“…The results of the microbial community showed that compared with the non-additives group, the Shannon index decreased and the Simpson index increased in the compound lactic acid bacteria group, indicating a significant reduction in microbial diversity in the silage environment (P < 0.05). …”
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5912
Table 2_Analysis of risk factors in breast cancer patients with hand-foot syndrome and oral mucositis caused by pegylated liposomal doxorubicin.doc
Published 2025“…Severe cases may necessitate a reduced PLD dose or even delay or interrupt chemotherapy, ultimately leading to decreased medication compliance. …”
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5913
Table 4_The SlERF4-9-SlCDF1/3-SlAEC2/SlPIN5 module regulates tomato root morphogenesis.xlsx
Published 2025“…In this study, the seed germination rate and seedling growth were reduced in the tomato slerf4-9 mutant. The fresh weight, drought weight, number of primary lateral roots (LRs), average root diameter, and number of root tips were also decreased in the mutant. …”
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5914
Table 5_The SlERF4-9-SlCDF1/3-SlAEC2/SlPIN5 module regulates tomato root morphogenesis.xlsx
Published 2025“…In this study, the seed germination rate and seedling growth were reduced in the tomato slerf4-9 mutant. The fresh weight, drought weight, number of primary lateral roots (LRs), average root diameter, and number of root tips were also decreased in the mutant. …”
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5915
Table 3_The SlERF4-9-SlCDF1/3-SlAEC2/SlPIN5 module regulates tomato root morphogenesis.xlsx
Published 2025“…In this study, the seed germination rate and seedling growth were reduced in the tomato slerf4-9 mutant. The fresh weight, drought weight, number of primary lateral roots (LRs), average root diameter, and number of root tips were also decreased in the mutant. …”
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5916
Image 1_The SlERF4-9-SlCDF1/3-SlAEC2/SlPIN5 module regulates tomato root morphogenesis.jpeg
Published 2025“…In this study, the seed germination rate and seedling growth were reduced in the tomato slerf4-9 mutant. The fresh weight, drought weight, number of primary lateral roots (LRs), average root diameter, and number of root tips were also decreased in the mutant. …”
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5917
Data Sheet 1_Immune monitoring of trabectedin therapy in refractory soft tissue sarcoma patients - the IMMUNYON study.pdf
Published 2025“…PD patients showed reduced eosinophils (p<0.05) and Th2 cells (p<0.05). …”
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5918
Table 2_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx
Published 2025“…</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”
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5919
Image 2_The SlERF4-9-SlCDF1/3-SlAEC2/SlPIN5 module regulates tomato root morphogenesis.jpeg
Published 2025“…In this study, the seed germination rate and seedling growth were reduced in the tomato slerf4-9 mutant. The fresh weight, drought weight, number of primary lateral roots (LRs), average root diameter, and number of root tips were also decreased in the mutant. …”
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5920
Table 4_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx
Published 2025“…</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”