Image 2_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Cochlear histology revealed reduced hair cell and spiral ganglion cell counts, as well as decreased Na⁺/K⁺-ATPase α1 expression and endocochlear potential. …”

Image 1_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Cochlear histology revealed reduced hair cell and spiral ganglion cell counts, as well as decreased Na⁺/K⁺-ATPase α1 expression and endocochlear potential. …”

Image 4_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…Cochlear histology revealed reduced hair cell and spiral ganglion cell counts, as well as decreased Na⁺/K⁺-ATPase α1 expression and endocochlear potential. …”

A game-theoretic analysis for creative mid-roll ads on a content platform by Shaofu Du (3359846)

“…<p>The accessibility of pre-roll ads (PAs) has significantly diminished due to the privilege of skipping ads for paid members. …”

Data Sheet 1_Non-targeted metabolomics-mediated elucidation of metabolite changes in Polygonatum kingianum during traditional steaming with black beans.zip by Haiyan Zhu (110483)

“…Compared to the raw PK, the P3 stage exhibited significant increases in saponins, total sugars, organic acids, and flavonoids by 21.29, 35.02, 49.13, and 44.76%, respectively (p < 0.05), reducing sugars showed a remarkable increase of 160.94-fold (p < 0.01), while polysaccharides decreased significantly by 43.33% (p < 0.01).…”

Data Sheet 1_Visual attention during non-immersive virtual reality balance training in older adults with mild to moderate cognitive impairment: an eye-tracking study.pdf by Marcos Maldonado-Díaz (11221102)

“…Clinical tests revealed a slight increase, though results were not statistically significant in balance and walking speed (p = 0.063). …”

Table 1_Bone mineral content determined by energy X-ray absorptiometry correlates with handgrip strength in Latin American divers.docx by Alex Véliz (21709934)

“…</p>Results<p>T3DE showed significant differences vs. T1DE group in BMC_Legs (diff. −107.9 g, p = 0.029), BMC_RL (diff. −51.4 g, p = 0.039), and BMC_LL (diff. −55.7 g, p = 0.037). …”

Image 2_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.jpeg by Zebanuer Yuemaierjiang (22702064)

“…</p>Results<p>β-PGG was identified as a promising PCID2-targeting compound by molecular docking, and SPR confirmed its direct binding to PCID2. β-PGG significantly reduced HCC cell proliferation, migration, and invasion, while inducing apoptosis and cell cycle arrest. …”

Table 2_Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response.xlsx by Tong Luo (458639)

“…</p>Results<p>CNS significantly improved survival, reduced pulmonary edema, and alleviated lung inflammation and locomotor deficits in LPS-challenged mice. …”

Supplementary Material for: DOT1L regulates cellular senescence during the progression from acute kidney injury to chronic kidney disease via the micro-222-5p/WNT9B signaling pathw... by figshare admin karger (2628495)

“…Results: The results demonstrated that in vivo inhibition of DOT1L significantly reduced cellular senescence and improved renal tubular injury and interstitial fibrosis. …”

Autophagy induced by mechanical stress sensitizes cells to ferroptosis by NCOA4-FTH1 axis by Chenyu Luo (12443535)

“…In this study, we reveal that heightened mechanical tension sensitizes cells to ferroptosis, whereas decreased mechanics confers resistance. Mechanistically, reduced mechanical tension reduces intracellular free iron levels by enhancing FTH1 protein expression. …”

Supplementary file 1_A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation.docx by Zebanuer Yuemaierjiang (22702064)

“…</p>Results<p>β-PGG was identified as a promising PCID2-targeting compound by molecular docking, and SPR confirmed its direct binding to PCID2. β-PGG significantly reduced HCC cell proliferation, migration, and invasion, while inducing apoptosis and cell cycle arrest. …”

Image 1_The alteration of the sensorimotor network in trigeminal neuralgia after microvascular decompression surgery: a follow-up study using independent component analysis.tif by Yan Zhang (8098)

“…Compared to the HC, long-term increased activity was still present in the right frontal operculum cortex, right insular cortex, right inferior frontal gyrus (pars opercularis), and right frontal pole despite the effectiveness of MVD surgery. In contrast, MVD significantly reduced the area of aberrant activation regions, particularly in the operculo-insular cortex, and also normalized cerebellar abnormalities.…”

Table 1_Cornuside mitigates acute lung injury through suppression of NLRP3 inflammasome-mediated pyroptosis and activation of the Keap1-Nrf2 antioxidant response.xlsx by Tong Luo (458639)

“…</p>Results<p>CNS significantly improved survival, reduced pulmonary edema, and alleviated lung inflammation and locomotor deficits in LPS-challenged mice. …”

Table 7_Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model.xlsx by Zhijian Zha (19451405)

“…</p>Results<p>In the danazol-induced CPP model, luteolin treatment significantly decreased the abundances of Estradiol (E2), luteinizing hormone serum, and follicle-stimulating hormone in sera; reduced organ coefficients and ovarian and uterine wet weights; and delayed vaginal opening. …”

Image 1_COP1 drives renal cell carcinoma progression by targeting ACSL4 for ubiquitin-mediated degradation and inhibiting ferroptosis.tif by Yuxiao Zheng (8334027)

“…Mechanistically, COP1 directly bound ACSL4 and promoted its K48-linked ubiquitination, reducing ACSL4 protein stability by 70% (p < 0.001) and suppressing ferroptosis, as evidenced by decreased lipid ROS levels (p < 0.01) and reversal of ferroptosis inhibition by ferrostatin-1. …”

Image 4_The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways.tiff by Priscila Silva (556743)

“…</p>Results<p>Heat-inactivated OpdA significantly reduced metastasis, dependent on tumor-specific CD4+ and CD8+ T cells and IFN-γ, both locally and systemically, with decreased IL-10 levels suggesting a proinflammatory environment. …”

Image 1_Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7... by Chunmei Ren (10921089)

“…</p>Results<p>Metformin significantly reduced periapical bone destruction on postoperative days 21 and 28, and decreased the number of osteoclasts on the periapical alveolar bone on postoperative day 28. …”

Table 2_Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model.xlsx by Zhijian Zha (19451405)

“…</p>Results<p>In the danazol-induced CPP model, luteolin treatment significantly decreased the abundances of Estradiol (E2), luteinizing hormone serum, and follicle-stimulating hormone in sera; reduced organ coefficients and ovarian and uterine wet weights; and delayed vaginal opening. …”

Data Sheet 1_Tcirg1 deficiency delays osteoarthritis progression by impairing lysosome acidification and peripheral accumulation in osteoclasts.docx by Rui Sun (177521)

“…Tcirg1 deficiency in knockout mice delayed OA progression, as evidenced by reduced cartilage damage, improved subchondral bone mass, and decreased osteoclast activity. …”