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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
reduced decrease » reduced disease (Expand Search), reported decrease (Expand Search), induces decreased (Expand Search)
significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
reduced decrease » reduced disease (Expand Search), reported decrease (Expand Search), induces decreased (Expand Search)
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6521
Data Sheet 1_Celecoxib prevents malignant progression of smoking-induced lung tumors via suppression of the COX-2/PGE2 signaling pathway in mice.pdf
Published 2025“…Lung adenomas were characterized by abundant COX-2-positive cells. Celecoxib reduced intermittent smoking-induced inflammation, emphysema, and cell counts in the bronchoalveolar lavage fluid and decreased the incidence of lung adenocarcinomas, whereas the total number of observed lung tumors was unchanged. …”
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6522
Data Sheet 1_Case Report: A case of first-line treatment for rare ROS1 fusion mutation lung adenocarcinoma with entrectinib.pdf
Published 2025“…Subsequently, the patient underwent whole-brain radiotherapy. Significant improvements were noted in her headache and insomnia symptoms. …”
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6523
Data Sheet 1_Divergent trends and regional disparities in PM2.5 and O3 health economic burdens in China, 2013–2023: an integrated assessment with policy implications.zip
Published 2025“…Conversely, O<sub>3</sub>-related mortality exhibited a significant upward trend. At reference concentrations of 0 and 60 μg/m<sup>3</sup>, all-cause mortality increased by 24.25% (365,084 cases) and 79.70% (372,724 cases), respectively. …”
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6524
Data Sheet 2_Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis.zip
Published 2025“…</p>Conclusion<p>ART and PMT demonstrated comprehensive benefits across multiple metabolic and inflammatory outcomes. ART effectively reduced BMI, improved glycemic control, and decreased inflammatory markers through mechanisms involving AMPK and mTOR pathways. …”
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6525
<i>Tmprss6</i> modulates radiation-induced liver injury through the hepcidin axis and PI3K/AKT pathway
Published 2025“…<p>Radiation-induced liver injury (RILI) poses a significant challenge in abdomino-pelvic tumor radiotherapy, adversely impacting normal liver tissues. …”
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6526
Data Sheet 1_Comparison of intravascular imaging, physiological assessment and angiography for coronary revascularization in acute coronary syndrome: a systematic review and networ...
Published 2025“…The research unveiled no statistically significant differences between FFR-guided culprit-only PCIs and culprit-only PCIs or angiography-guided CR.…”
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6527
Data Sheet 1_Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis.zip
Published 2025“…</p>Conclusion<p>ART and PMT demonstrated comprehensive benefits across multiple metabolic and inflammatory outcomes. ART effectively reduced BMI, improved glycemic control, and decreased inflammatory markers through mechanisms involving AMPK and mTOR pathways. …”
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6528
Identification of novel pathogenic mutations in <i>ATP6V0A4</i> associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease
Published 2025“…If untreated, it can result in a significant electrolyte imbalance and progressive chronic kidney disease (CKD). …”
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6529
Image 1_Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis.png
Published 2025“…</p>Conclusion<p>ART and PMT demonstrated comprehensive benefits across multiple metabolic and inflammatory outcomes. ART effectively reduced BMI, improved glycemic control, and decreased inflammatory markers through mechanisms involving AMPK and mTOR pathways. …”
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6530
Data Sheet 1_Microbial dysbiosis in obstructive sleep apnea: a systematic review and meta-analysis.docx
Published 2025“…Beta diversity analysis indicated significant differences in the gut, respiratory and oral microbial community structure between individuals with OSA and those without in more than half of the included studies. …”
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6531
Supplementary file 1_Integrating Drosophila and Vibrio fischeri models for toxicity evaluation: uncovering detoxification trends in psoralea Fructus-TCM formulations.docx
Published 2025“…Enzyme assays indicated a decreasing toxicity trend for ESP and SSP compared to PF, with significant changes observed in female flies. …”
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6532
Table 1_Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis.docx
Published 2025“…</p>Conclusion<p>ART and PMT demonstrated comprehensive benefits across multiple metabolic and inflammatory outcomes. ART effectively reduced BMI, improved glycemic control, and decreased inflammatory markers through mechanisms involving AMPK and mTOR pathways. …”
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6533
Image 1_Multi-omics analysis reveals indicator features of microbe-host interactions during Candida albicans colonization and subsequent infection.tif
Published 2024“…</p>Importance<p>Candida albicans invasive infections pose a significant challenge to contemporary medicine, with mortality rates from such fungal infections remaining high despite antifungal treatment. …”
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6534
Data Sheet 3_Divergent trends and regional disparities in PM2.5 and O3 health economic burdens in China, 2013–2023: an integrated assessment with policy implications.zip
Published 2025“…Conversely, O<sub>3</sub>-related mortality exhibited a significant upward trend. At reference concentrations of 0 and 60 μg/m<sup>3</sup>, all-cause mortality increased by 24.25% (365,084 cases) and 79.70% (372,724 cases), respectively. …”
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6535
Supplementary file 1_Characterization of the gut microbiota in people with different levels of obesity.docx
Published 2025“…</p>Results<p>In obese populations, the gut microbiome structure shifted significantly, with beneficial genera like Faecalibacterium, Roseburia, and Ruminococcus decreasing, and potentially harmful genera such as Blautia, Collinsella, and Streptococcus increasing. …”
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6536
Data Sheet 1_Patterns of plant organ-level non-structural carbohydrate content in response to nitrogen and phosphorus enrichment.docx
Published 2025“…The NSC content in herbaceous plants was more sensitive to nutrient enrichment, with N enrichment significantly reducing their NSC reserves across all organs (by up to 90.72%). …”
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6537
Table_1_Characterization of the microbial communities and their correlations with volatile flavor compounds and physicochemical factors in Bashang suancai, a traditional Chinese pi...
Published 2024“…The bacterial community diversity decreased significantly following 7 days of fermentation. …”
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6538
Supplementary file 1_Prolonged effect of antibiotic therapy on the gut microbiota composition, functionality, and antibiotic resistance genes’ profiles in healthy stool donors.zip...
Published 2025“…</p>Results<p>Antibiotics caused lasting disruption to bacterial communities, significantly reducing important taxa like Bifidobacterium bifidum, Blautia wexlerae, Akkermansia muciniphila, Eubacterium sp. …”
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6539
Transgenic barley over-expressing <i>Aspergillus niger</i> phytase phyA in field trials
Published 2025“…Increased phytase activity gradually decreased over the generations showing the most significant drop in the initial years of field trials. …”
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6540
Data Sheet 1_Mechanism of salidroside promoting testosterone secretion induced by H2O2 in TM3 Leydig cells based on metabolomics and network pharmacology.zip
Published 2025“…The study investigated the oxidative damage in TM3 cells induced by H<sub>2</sub>O<sub>2</sub> and demonstrated that salidroside significantly decreased the levels of ROS and MDA, while increasing the levels of testosterone, SOD, GSH. …”