Loss of b-cell K_ATP reduces Ca²⁺ sensitivity of insulin secretion and <i>Trpm5</i> expression by Nathaniel W. York (20410828)

“…</a><a href="" target="_blank">Glibenclamide pellet-implanted <i>Trpm5</i> KO mice also exhibited significant glucose intolerance. However, this was not as severe as in WT animals, which suggests that decreased expression of <i>Trpm5</i> may play a small role in the disruption of insulin secretion with K_ATP loss.…”

Image4_Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin.J... by Fereshteh Sadeghian (19848177)

“…On the inner surface of the spermathecal tube, tension on the apical junctions is decreased by depletion of PLC-1 and NMY-1. Surprisingly, when basal contractility is increased through SPV-1 depletion, the tension on apical junctions also decreases, with the most significant effect on the junctions aligned in perpendicular to the axis of the spermatheca.…”

Video3_Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin.A... by Fereshteh Sadeghian (19848177)

“…On the inner surface of the spermathecal tube, tension on the apical junctions is decreased by depletion of PLC-1 and NMY-1. Surprisingly, when basal contractility is increased through SPV-1 depletion, the tension on apical junctions also decreases, with the most significant effect on the junctions aligned in perpendicular to the axis of the spermatheca.…”

Video 1_Quantitative comparisons of pulmonary artery hemodynamics before and after Pulsta valve implantation in patients with Tetralogy of Fallot using computational fluid dynamics... by Seung Min Baek (13994226)

“…After PPVI, the vorticity (RPA; 3.9–1.6/s, p = 0.008, LPA; 4.4–1.8/s, p = 0.011, MPA; 5.4–1.5/s, p = 0.008), and energy dissipation (104.1–38.1 mW, p = 0.028) decreased significantly, whereas changes in the Womersley and Reynolds numbers were not statistically significant. …”

Table 1_Effect of low salicylate diet and blood salicylate level on the symptom control of chronic spontaneous urticaria.docx by Sercan Guloglu (22801190)

“…The CU-Q2oL scores significantly decreased from 33.7 to 20.7 (p < 0.001) and the UAS4 significantly decreased from 14 to 8 (p < 0.001) after low salicylate diet when compared to baseline (low scores mean less complaints). …”

Table 3_Mendelian randomization and bioinformatics unveil potential links between gut microbial genera and colorectal cancer.xlsx by Long Wu (655081)

“…Background<p>Colorectal cancer (CRC) poses a significant global health burden, with high incidence and mortality rates. …”

Data Sheet 1_HIV drug resistance and its associated factors among patients during interruption of antiretroviral therapy in China.docx by Zhongbao Zuo (3594755)

“…The HIV drug resistance rate and the frequency of patients harboring ≥2 drug resistance mutations decreased significantly in the longer interruption time group. …”

Data Sheet 1_Hyperbaric oxygen therapy for radiation enteritis and clinical parameters: a systematic review and meta-analysis.docx by Yuhan Wang (595964)

“…Moderate-quality evidence suggested that HBOT could significantly reduce the incidence of RE [OR = 0.32, 95% CI (0.14, 0.72), P = 0.006], particularly showing a significant advantage in decreasing the incidence of grade 3 or higher RE according to the RTOG/EORTC criteria [OR = 0.37, 95% CI (0.17, 0.82), P = 0.01]. …”

Table 1_Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease.docx by Xi Luo (361139)

“…Both PD models predicted reduced uptake of lysine and lactate, indicating coordinated metabolic processes between these components. In contrast, decreased methionine and urea uptake was exclusively predicted in the synaptic PD model, while decreased histidine and glyceric acid uptake was exclusive to the non-synaptic PD model. …”

Rescue of <i>pbp1</i>-KD phenotypes using CRISPRi trans-complementation. by Gregory A. Harrison (16639446)

“…Yellow arrows point to a subset of PBP1-depleted cells that have decreased RADA signal, likely due to decreased peptidoglycan metabolism. …”

Video1_Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin.A... by Fereshteh Sadeghian (19848177)

“…On the inner surface of the spermathecal tube, tension on the apical junctions is decreased by depletion of PLC-1 and NMY-1. Surprisingly, when basal contractility is increased through SPV-1 depletion, the tension on apical junctions also decreases, with the most significant effect on the junctions aligned in perpendicular to the axis of the spermatheca.…”

Image 1_Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro.jpeg by Chioma Moneme (20457845)

“…Piezo1 inhibition also led to significantly increased neuronal migration, whereas Piezo1 activation resulted in significantly decreased neuronal migration and slower neuronal recovery from injury.…”

The global disability-adjusted life years (DALYs) for asthma attributable to nitrogen dioxide pollution from 1990 to 2021 and predicted the trends from 2022 to 2050 by Yaping Feng (427666)

“…Additionally, it is still quite significant for children under the age of 15 and in some underdeveloped regions.…”

Table 1_Evaluation of hypoxia-inducible factor-1α and urine non-transferrin-bound iron concentrations in cats with chronic kidney disease.docx by Chien-Hui Chen (2524213)

“…/mL in early-stage CKD cats but decreased to 8.50 pg./mL in late-stage CKD cats. uHIF-1α concentrations gradually decreased with a significant difference between the control group (44.61 pg.…”

Table_1_Olfactory dysfunction as an early pathogenic indicator in C. elegans models of Alzheimer's and polyglutamine diseases.xlsx by Weikang Xue (19768329)

“…Notably, AWB neurons in both models showed significantly shortened cilia and increased instances of enlarged cilia as early as day 1 of adulthood. …”

Inc exhibits key properties of a Cul3 adaptor in neurons in vivo. by Qiuling Li (390393)

“…Neuronal <i>Cul3</i> RNAi decreases <i>Cul3</i> transcript levels but does not significantly alter those of <i>inc</i>. …”

Figure 4 from Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non–Small Cell Lung Cancer Patients by Lauren Polyakov (21672045)

“…<p>Continued use of corticosteroids during anti–PD-L1 therapy correlates with decreased survival in a preclinical model. <b>A,</b> Experimental set-up. …”

Image 5_Salt tolerance characterization and genome-wide association study of Gossypium barbadense accessions reveal salinity-adaptive variations.jpeg by Huazu Li (22228792)

“…VIGS of GbXTH27 exacerbated salt-induced wilting phenotypes and significantly decreased antioxidant enzyme activities.…”

Data Sheet 2_Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury.pdf by Sofie Vandendriessche (638514)

“…Importantly, C3 deficiency led to a significant accumulation of necrotic debris and impairment of liver recovery in mice, which was attributed to decreased phagocytosis of debris by recruited neutrophils in vivo. …”

Data Sheet 1_Long-term nitrogen fertilization alters the partitioning of amino acids between citrus leaves and fruits.docx by Yuanlai Zhao (20548445)

“…As fruits entered the swelling stage, a significant positive correlation emerged between fruiting branch leaves and fruit total N content (R²=0.68), while the R² for leaves on non-fruiting branches dropped to 0.47, indicating a shift in N supply towards leaves on fruiting branches. …”