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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significantly we » significantly _ (Expand Search), significantly i (Expand Search), significantly lower (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
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5341
Genetic insights into the interaction between chronic hepatitis B virus infection and metabolic syndrome
Published 2025“…<p>The association between chronic hepatitis B virus (HBV) infection and metabolic syndrome (MetS) remains controversial. We aimed to analyze the causal effects of chronic HBV infection on MetS components and vice versa. …”
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5342
Table 1_Mortality and trends of pulmonary arterial hypertension, 1990–2021: a population-based study.docx
Published 2025“…Of note, there were significant health inequalities across 204 countries and territories, with the slope index of inequality rising over time. …”
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5343
Data Sheet 3_Identification of the malonylation modification in Staphylococcus aureus and insight into the regulators in biofilm formation.pdf
Published 2025“…</p>Results<p>Quantitative profiling identified 2,833 malonylated sites across 788 proteins, with significant enrichment in biofilm-associated proteins. …”
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5344
Table 1_Integrative stress management for global workforce: music-based and exercise intervention for overseas employees.docx
Published 2025“…</p>Results<p>The experimental group demonstrated significant stress reduction (GARS scores decreased from 3.59 ± 0.71 to 2.68 ± 0.57, p < 0.001), with effects sustained at 6 months (p < 0.05). …”
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5345
Data Sheet 2_Identification of the malonylation modification in Staphylococcus aureus and insight into the regulators in biofilm formation.xlsx
Published 2025“…</p>Results<p>Quantitative profiling identified 2,833 malonylated sites across 788 proteins, with significant enrichment in biofilm-associated proteins. …”
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5346
Table 1_Nutritional and inflammatory biomarkers in predicting spontaneous anastomotic leakage closure following enterocutaneous fistula resection: the role of postoperative CRP-lym...
Published 2025“…</p>Methods<p>In this retrospective cohort analysis, we examined adult patients who experienced AL following ECF resection from January 2019 to January 2024. …”
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5347
Table 4_Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto’s thyroiditis: insights from efferocytosis regulation.xlsx
Published 2025“…Moreover, TCM offers significant benefits in regulating lipid metabolism and decreasing systemic inflammation.…”
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5348
Data Sheet 1_Active layer and permafrost microbial community coalescence increases soil activity and diversity in mixed communities compared to permafrost alone.docx
Published 2025“…Microbial communities undergo significant compositional and functional shifts as permafrost thaws. …”
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5349
Image 1_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden...
Published 2025“…</p>Methods<p>This study utilized the Global Burden of Disease (GBD) database to examine trends in CHD-related mortality among children aged 0-14 from 1990 to 2021.</p>Results<p>We report a 55.34% reduction in CHD-related deaths among children, with global mortality rates decreasing from 28.63 per 100,000 in 1990 to 11.06 per 100,000 in 2021. …”
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5350
Data Sheet 1_Comprehensive analysis on the regulatory mechanism of active ingredient accumulation during fermentation process of Massa Medicata Fermentata: microbe and metabolic pr...
Published 2025“…Background<p>Massa Medicata Fermentata (MMF) is a traditional medicinal/edible fermented product; however, comprehensive research on the fermentation process from a microscopic perspective remains limited. In this study, we aimed to investigate the dynamic changes and correlations of physicochemical properties, microbial communities, and metabolite profiles in different fermentation stages (0, 48, 72, and 96 h) of MMF.…”
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5351
Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies
Published 2025“…Chemoresistance in cancer can arise from a variety of molecular mechanisms, including active drug expulsion (drug efflux), decreased drug uptake, enhanced DNA repair mechanisms, the ability of cancer cells to evade programmed cell death (apoptosis), the diversity in the population of cancer cells within a tumor (tumor heterogeneity), and significant alterations in the tumor microenvironment (TME), where interactions between cancer cells, cancer-associated fibroblasts, immune cells, and the extracellular matrix contribute to a supportive environment that allows tumors to survive treatment and escape therapy. …”
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5352
Table 2_The global, regional, and national alcohol-related colorectal cancer burden and forecasted trends: results from the global burden of disease study 2021.csv
Published 2024“…Background<p>The mortality of colorectal cancer (CRC) is increasing year by year and poses a significant global health burden. Many studies have demonstrated that alcohol consumption is an important risk factor for CRC and is closely associated with malignant metastasis in CRC patients, which in turn leads to a poor prognosis.…”
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5353
Table 2_Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden...
Published 2025“…</p>Methods<p>This study utilized the Global Burden of Disease (GBD) database to examine trends in CHD-related mortality among children aged 0-14 from 1990 to 2021.</p>Results<p>We report a 55.34% reduction in CHD-related deaths among children, with global mortality rates decreasing from 28.63 per 100,000 in 1990 to 11.06 per 100,000 in 2021. …”
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5354
Supplementary file 1_Global burden of pulmonary sarcoidosis from 1990 to 2021: a comprehensive analysis based on the GBD 2021 study.xlsx
Published 2025“…Nationally, the burden of the disease in 2021 is particularly significant in countries such as Mauritius and Italy. …”
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5355
Supplementary file 4_Global burden of pulmonary sarcoidosis from 1990 to 2021: a comprehensive analysis based on the GBD 2021 study.xlsx
Published 2025“…Nationally, the burden of the disease in 2021 is particularly significant in countries such as Mauritius and Italy. …”
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5356
Data Sheet 1_Robotic hormonal and autonomic modulation for type 2 diabetes: ileal interposition and hepatic sympathectomy.pdf
Published 2025“…The first patient showed significant weight loss and reduced insulin requirements after 12 months. …”
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5357
Divergent Oncogenic Signaling and Immune Microenvironment Changes in Low-Grade Serous Ovarian Cancer Undergoing Intraperitoneal Treatment
Published 2025“…The non-responder demonstrated significant upregulation in proliferation-associated pathways (E2F, MYC targets, G2/M checkpoint), KRAS signaling, epithelial-mesenchymal transition, and unfolded protein response (UPR), correlating with aggressive tumor growth and treatment resistance. …”
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5358
An improved <i>in vitro</i> 3T3-L1 adipocyte model of inflammation and insulin resistance
Published 2024“…Importantly, insulin resistance and inflammation were still induced in the 12 h treated adipocytes: the expression of the insulin sensitive and inflammatory genes was decreased and increased, respectively. In 72 h treated adipocytes, no significant differences were found in the viability, glucose uptake or insulin-sensitive and inflammatory gene expression. …”
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5359
Data Sheet 1_Food and mood: how clean eating content on social media influences affect and body satisfaction in women.docx
Published 2025“…</p>Results<p>There was no significant profile × time interaction effect for positive affect, however it decreased over time (<sub>p</sub><sup>2</sup> = 0.21). …”
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5360
Image 4_The global, regional, and national alcohol-related colorectal cancer burden and forecasted trends: results from the global burden of disease study 2021.tif
Published 2024“…Background<p>The mortality of colorectal cancer (CRC) is increasing year by year and poses a significant global health burden. Many studies have demonstrated that alcohol consumption is an important risk factor for CRC and is closely associated with malignant metastasis in CRC patients, which in turn leads to a poor prognosis.…”