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    Mathematical modelling indicates that <i>APC</i> mutations cause decreased maturation of ALDH+ SCs into progenitor NECs. by Tao Zhang (43681)

    Published 2020
    “…<b>(D)</b> The stem cell reproduction number (<i>R</i><sub><i>w</i></sub>) is increased in <i>APC</i>-mutant tissues. The modeling results also indicated that the division rate of SCs decreased in colonic crypts during the progression from normal to cancer as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0239601#pone.0239601.s001" target="_blank">S1 File</a>. …”
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