بدائل البحث:
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
decrease increased » degree increased (توسيع البحث), disease increases (توسيع البحث)
reduction decrease » reduction decreased (توسيع البحث), reduction reuse (توسيع البحث), production increases (توسيع البحث)
significant decrease » significant increase (توسيع البحث), significantly increased (توسيع البحث)
decrease increased » degree increased (توسيع البحث), disease increases (توسيع البحث)
reduction decrease » reduction decreased (توسيع البحث), reduction reuse (توسيع البحث), production increases (توسيع البحث)
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Validation of primary screen hits reveals compounds that recapitulate increased spheroid size (swell) or decreased MUC5AC in the lumen.
منشور في 2023"…Compounds that appeared to cause toxicity were identified by observing a significant decrease in spheroid counts in the swell readout or a significant decrease in the total nuclear intensity of the MUC5AC ratio readout. …"
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Hyperplasia of the suboccipital muscles significantly increased intracranial pressure.
منشور في 2022الموضوعات: -
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Image1_Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models.jpg
منشور في 2022"…We also found that the knockdown and knockout (KO) of KIFf5B significantly decreased the tau stability, and overexpression of KIF5B in KIF5B-KO cells significantly increased the expression of phosphorylated and total tau levels. …"
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