Transcription and expression levels of CK8 in Caco-2 cells after CK8 gene was knocked down. حسب Wen Wen Zheng (17721404)

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qPCR and Western blotting of activation of CK8 receptor and RhoA/ROCK1 pathway proteins in Caco-2 cells treated with rTsSPc and IIL ES antigens. حسب Wen Wen Zheng (17721404)

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CK8 knockdown and ROCK1 inhibitor suppressed rTsSPc-induced disruption of the Caco-2 monolayer and blocked rTsSPc-promoted IIL invasion. حسب Wen Wen Zheng (17721404)

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Intraperitoneal injection protocol for inhibitors (A), inhibitors DAS and Y27632 reduced intestinal permeability (B) and intestinal adult worm burden (C) of infected mice. حسب Wen Wen Zheng (17721404)

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HE staining showed that DAS and Y27632 alleviated intestinal inflammation in <i>T. spiralis</i>-infected mice. حسب Wen Wen Zheng (17721404)

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The ROCK1 pathway inhibitor Y27632 prevented rTsSPc from activating the ROCK1 pathway and reducing TJs expression. حسب Wen Wen Zheng (17721404)

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qPCR (A-D) and ELISA (E-H) detection of inflammatory cytokines in intestine of <i>T. spiralis</i>-infected mice. حسب Wen Wen Zheng (17721404)

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mRNA-specific primers of genes. حسب Li-Hong Chen (610826)

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PTable S1 The gene expression before batch effect removal. حسب Li-Hong Chen (610826)

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Basic information of retrieved datasets. حسب Li-Hong Chen (610826)

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Differential expression analysis after merging datasets GSE28750, GSE65682, GSE69528, and GSE137342. حسب Li-Hong Chen (610826)

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POriginal blots. حسب Li-Hong Chen (610826)

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Identification of tryptophan metabolism-related gene CYP1B1 in sepsis. حسب Li-Hong Chen (610826)

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PTable S4 Expression validation of CYP1B1. حسب Li-Hong Chen (610826)

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PTable S2 Differentially expressed genes. حسب Li-Hong Chen (610826)

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The transfection efficiency of CYP1B1 knockdown in THP-1 cells. حسب Li-Hong Chen (610826)

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Knockdown of CYP1B1 inhibited monocytes activation and tryptophan metabolism. حسب Li-Hong Chen (610826)

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PTable S5 Markers of each cell cluster. حسب Li-Hong Chen (610826)

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The specific expression of CYP1B1 were explored in different cell types at single-cell level. حسب Li-Hong Chen (610826)

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Validation of CYP1B1 expression in THP-1 monocytes. حسب Li-Hong Chen (610826)

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