K⁺ Channel Inhibition Differentially Regulates Migration of Intestinal Epithelial Cells in Inflamed vs. Non-Inflamed Conditions in a PI3K/Akt-Mediated Manner by Sebastian Zundler (2176762)

“…In contrast, inhibition of KCNN4 after pretreatment with IFN-γ led to decreased or unaffected migration. This effect was abolished by EGF. …”

Table_1_Vitamin D3 Attenuates Viral-Induced Inflammation and Fibrotic Responses in Bronchial Smooth Muscle Cells.pdf by Maria Plesa (2085994)

“…Ligation of TLR3 by polyI:C in BSMCs was associated with increased TLR3 mRNA expression, and 1,25D3 treatment significantly reduced its expression. In addition, 1,25D3 decreased the expression of IL-6, IFN-β1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs. …”

DataSheet1_Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviates Tripterygium Glycoside Tablet-Induced Acute Liver Injury by Regulating the Activities... by Qiaoli Shi (12084290)

“…Then the liver protective effect and mechanisms of GA were investigated by a combination of transcriptome, lipid metabolomics, and experimental validation.…”

DataSheet_1_Targeting Glutamine Metabolism Ameliorates Autoimmune Hepatitis via Inhibiting T Cell Activation and Differentiation.docx by Qiang Yu (5487)

“…Targeting glutamine metabolism has an impact on T cell activation and differentiation. However, the effect of glutamine metabolism blocking upon AIH remains unknown. …”

DataSheet_2_Impact of age and comorbidities on short- and long-term outcomes of patients undergoing surgery for colorectal cancer.docx by Giulia Turri (10303154)

“…</p>Methods<p>A total of 1,482 patients operated for CRC at our institution between January 2005 and October 2020 were analysed. The independent effect of age and comorbidities on postoperative complications was assessed by a logistic model, while the effect on overall survival (OS) and cancer-related survival (CRS) was estimated by a Cox regression model.…”

Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells – Liquid biopsies for monitoring complications of pregnancy by Grace Truong (485045)

“…The number of exosomes was significantly higher in EVT cultured under 1% compared to 8% oxygen. …”

Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta_25–35 via the Autophagy Pathway by Pengjuan Xu (314036)

“…Our experiments show that cell viability is significantly decreased, and the apoptosis increased in Aβ_25–35-treated differentiated PC12 cells. …”

Data_Sheet_1_Probiotics, Prebiotics, and Synbiotics Improve Uremic, Inflammatory, and Gastrointestinal Symptoms in End-Stage Renal Disease With Dialysis: A Network Meta-Analysis of... by Zixian Yu (8876978)

“…</p>Conclusion<p>Our research indicated prebiotics were more effective in declining IL-6, TNF-α, IS, MDA, and BUN, synbiotics lowering CRP and endotoxin significantly, and probiotics were beneficial for alleviating GI symptoms, which may contribute to better clinical decisions. …”

Data_Sheet_1_Fructose Induces Visceral Adipose Tissue Inflammation and Insulin Resistance Even Without Development of Obesity in Adult Female but Not in Male Rats.pdf by Sanja Kovačević (11680018)

“…</p><p>Methods: We analyzed effects of 9-week 10% fructose-enriched diet on energy intake, VAT mass and histology, and systemic insulin sensitivity. …”

Data_Sheet_1_Probiotics, Prebiotics, and Synbiotics Improve Uremic, Inflammatory, and Gastrointestinal Symptoms in End-Stage Renal Disease With Dialysis: A Network Meta-Analysis of... by Zixian Yu (8876978)

“…</p>Conclusion<p>Our research indicated prebiotics were more effective in declining IL-6, TNF-α, IS, MDA, and BUN, synbiotics lowering CRP and endotoxin significantly, and probiotics were beneficial for alleviating GI symptoms, which may contribute to better clinical decisions. …”

DataSheet1_Insights Into Acute and Delayed Cisplatin-Induced Emesis From a Microelectrode Array, Radiotelemetry and Whole-Body Plethysmography Study of Suncus murinus (House Musk S... by Longlong Tu (5596706)

“…<p>Purpose: Cancer patients receiving cisplatin therapy often experience side-effects such as nausea and emesis, but current anti-emetic regimens are suboptimal. …”

Data_Sheet_1_Suitability of Slower Growing Commercial Turkey Strains for Organic Husbandry in Terms of Animal Welfare and Performance.PDF by Anna Olschewsky (9943502)

“…HoBr with a similar growth rate compared to Kelly had slightly more problems concerning walking ability and plumage damage, but also less breast buttons than Kelly turkeys. However, effect sizes were negligible (Φ < 0.10), except for the higher occurrence of footpad dermatitis and the reduced number of breast buttons in HoBl with small effect sizes (Φ = 0.20–0.24). …”

Data_Sheet_1_Involvement of NMDA-AKT-mTOR Signaling in Rapid Antidepressant-Like Activity of Chaihu-jia-Longgu-Muli-tang on Olfactory Bulbectomized Mice.PDF by Xing Wang (154377)

“…</p><p>Results: A single dose of CLM significantly improved the deficiency in the sucrose preference and decreased the immobility time in the tail suspension test in OB mice. …”

Supplementary Material for: ACOT4 and ACOT6 activate Akt-mTOR pathway and inhibit calcium oxalate-induced renal tubular cell injury by figshare admin karger (2628495)

“…Acyl coenzyme A thioesterases (ACOTs) serve as the key regulators of fatty acids metabolism. However, ACOTs' effect on CaOx kidney stone formation remains to be explored. …”

Data_Sheet_1_Influence of Older Age and Other Risk Factors on Pneumonia Hospitalization in Switzerland in the Pneumococcal Vaccine Era.docx by Werner C. Albrich (3177693)

“…Older age with both age cut-offs were associated with increased LOS (≥50 years: aRR: 1.19 and 1.24, respectively; age ≥65 years: aRR: 1.60 and 1.20, respectively; p < 0.001 for all) and mortality (≥50 years: aOR: 4.73 and 2.84, respectively; age ≥65 years: aOR: 2.38 and 2.69, respectively, p < 0.001 for all) in patients with a pneumonia and pneumococcal pneumonia diagnosis, respectively. The effects of pneumococcal vaccine indications decreased with older age. …”

Table_2_Probiotics, Prebiotics, and Synbiotics Improve Uremic, Inflammatory, and Gastrointestinal Symptoms in End-Stage Renal Disease With Dialysis: A Network Meta-Analysis of Rand... by Zixian Yu (8876978)

“…</p>Conclusion<p>Our research indicated prebiotics were more effective in declining IL-6, TNF-α, IS, MDA, and BUN, synbiotics lowering CRP and endotoxin significantly, and probiotics were beneficial for alleviating GI symptoms, which may contribute to better clinical decisions. …”

Table_1_Investigating the Added Value of the EQ-5D-5L With Two Bolt-On Items in Patients With Hemophilia.DOCX by Richard Huan Xu (7901480)

“…</p><p>Results: A total of 895 patients and 222 caregivers completed the questionnaire. The ceiling effect decreased from 1.9 to 0.6% and 5.9 to 0.9% when using the EQ-5D-5L and the EQ-5D-5L with two bolt-on items among participants with both self- and proxy-completed questionnaires. …”

DataSheet1_The therapeutic efficacy of resveratrol for acute lung injury—A meta−analysis of preclinical trials.docx by Yin Tang (296253)

“…As compared with controls, RES significantly decreased the lung injury score (SMD −2.06; 95% CI −2.77, −1.35; p < 0.00001) and W/D ratio (SMD −1.92; 95% CI −2.62, −1.22; p < 0.00001). …”

File S1 - <i>Trypanosoma cruzi</i> Evades the Protective Role of Interferon-Gamma-Signaling in Parasite-Infected Cells by Philipp Stahl (443447)

“…(A,B) Twelve hours of pre-treatment with interferon-γ significantly decreased parasite load, as determined by reduced numbers of both infected cells (A) and intracellular amastigotes per cell (B). …”

DataSheet1_Dapagliflozin Reduces Apoptosis of Diabetic Retina and Human Retinal Microvascular Endothelial Cells Through ERK1/2/cPLA2/AA/ROS Pathway Independent of Hypoglycemic.ZIP by Yuxin Hu (454917)

“…The purpose of the presented study was to explore the effect of SGLT-2 inhibitors dapagliflozin (DAPA) on apoptosis of diabetic mice retina and human retinal microvascular endothelial cells (HRMECs), examine the effects of dapagliflozin on HRMECs metabolism, and explore the molecular processes that affect DR.…”