Image 1_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.tif by Jing Wang (6206297)

“…Furthermore, univariate and multivariate Cox analysis were used to assess the prognostic effects of ARPs. The investigation of immune cell infiltration and possible functional enrichment followed. …”

Image1_Efficacy and Safety of a Polysaccharide-Based Natural Substance Complex in the Treatment of Obesity and Other Metabolic Syndrome Components: A Systematic Review.TIF by Giuseppina Guarino (6795282)

“…</p><p>Conclusion: Policaptil Gel Retard^® is an effective and safe non-pharmacological approach to improve the treatment of MetS-associated cardiovascular risk factors in children, adolescents, and adults.…”

Data_Sheet_1_Training in psychosomatic medicine and psychotherapy for medical doctors in China: A field report.PDF by Jing Wei (127335)

“…On the patient side (n = 415), emotional distress decreased and quality of life and the doctor–patient alliance improved significantly.…”

Image4_17β-Estradiol Treatment Improves Acetylcholine-Induced Relaxation of Mesenteric Arteries in Ovariectomized UC Davis Type 2 Diabetes Mellitus Rats in Prediabetic State.JPEG by Md Rahatullah Razan (12889721)

“…Overall, our data suggest that 1) the impairment of ACh responses in PD OVX rats may, in part, result from the elevated contractile responses to PE, loss of contribution of endothelium-dependent hyperpolarization (EDH) to vasorelaxation, and a decreased sensitivity of MA to nitric oxide (NO), and 2) the basis for the protective effects of E₂ may be partly attributed to the elevation of the NO contribution to vasorelaxation and its interaction with MA as well as potential improvement of insulin signaling. …”

Table_1_Real-world experience with the cusp-overlap deployment technique in transcatheter aortic valve replacement: A propensity-matched analysis.pdf by Oliver Maier (4434097)

“…The rate of new permanent pacemaker implantation (PPI) following TAVR was effectively reduced (8.0 vs. 16.8%; p = 0.028). While the fluoroscopy time decreased (18.4 ± 7.6 vs. 19.8 ± 7.6 min; p = 0.023), the dose area product increased in the COT group (4951 ± 3662 vs. 3875 ± 2775 Gy × cm²; p = 0.005). …”

Table_3_Course of psychotic experiences and disorders among apprentice traditional health practitioners in rural South Africa: 3-year follow-up study.docx by Martine C. E. van der Zeijst (13879148)

“…</p>Results<p>At 3-year follow-up, psychotic experiences were associated with significantly less distress and there was a reduction in frequency of psychotic symptoms compared to baseline. …”

Image 5_Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia.png by Feifei Yang (334047)

“…We previously elucidated the direct effects of iron overload on AML cells. It’s worth noting that iron overload remodels the hematopoietic ecosystem. …”

Image 4_Establishment and validation of survival nomogram score staging for esophageal squamous cell carcinoma patients after minimally invasive surgery combined with immune progno... by Shao-jun Xu (11633956)

“…The dynamic mortality risk rate revealed a double peak in the high-risk patients (12 and 48 months) and a single peak in the low–risk patients (24 months) and middle-risk patients (12 months), which gradually decreased over time.</p>Conclusion<p>The SNS staging based on IPI and clinicopathological features can thus be applied to effectively evaluate the OS and DFS of ESCC patients after MIE. …”

Image_1_Resolvin D2 induces anti-microbial mechanisms in a model of infectious peritonitis and secondary lung infection.pdf by Prem Y. Kadiyam Sundarasivarao (14200934)

“…RvD2 reduced lung lavage bacterial load 24h after P. aeruginosa administration and significantly decreased lung lavage levels of IL-23, a cytokine essential in the Th-17 inflammatory response. …”

table3_eDNA Detection of Native and Invasive Crayfish Species Allows for Year-Round Monitoring and Large-Scale Screening of Lotic Systems.xlsx by Franziska Chucholl (10287689)

“…The newly developed eDNA assays successfully detected all crayfish species across different lotic and lentic habitats. eDNA detection rate (endpoint PCR) and eDNA-concentration (ddPCR) were significantly influenced by distance and season. eDNA detection was successful up to 7 km downstream of the source population and across all seasons, although detectability was lowest in winter. eDNA detection rate further decreased with increasing stream size. …”

Table_1_Diabetic macrophage small extracellular vesicles-associated miR-503/IGF1R axis regulates endothelial cell function and affects wound healing.docx by Jianqiang Wang (573651)

“…This study concluded that macrophage M1 polarization predominates in DFU skin tissue. iNOS was increased in HG-induced M1-polarized macrophages; conversely, Arg-1 was decreased. Macrophage pellets after HG stimulation can impair endothelial cell (EC) function by inhibiting cell viability, tube formation and cell migration, indicating M1 macrophage-derived small extracellular vesicles (sEVs) -mediated HUVEC dysfunction. sEVs miR-503 was significantly upregulated in response to HG stimulation, but inhibition of miR-503 in HG-stimulated macrophages attenuated M1 macrophage-induced HUVEC dysfunction. …”

Table 1_Ayahuasca partially preserves striatal integrity in juvenile non-human primates exposed to chronic stress: evidence from stereological evaluation.docx by Wigínio Gabriel de Lira-Bandeira (20749421)

“…Our objective was to morphoquantitatively evaluate the effects of ayahuasca on the St in an already validated model of juvenile depression induced in a non-human primate.…”

Strategy towards tailored donor tissue-specific pancreatic islet isolation by Yuki Miyazaki (290900)

“…</p><p>Results</p><p>No beneficial effects were observed by increasing the ColG amount, irrespective of the rat strain. …”

Image_4_Reversal of Endothelial Extracellular Vesicle-Induced Smooth Muscle Phenotype Transition by Hypercholesterolemia Stimulation: Role of NLRP3 Inflammasome Activation.tiff by Xinxu Yuan (7446968)

“…Using a Western diet (WD)-induced hypercholesterolemia mouse model, we found that endothelial-specific AC gene knockout mice (Asah1^fl/fl/EC^Cre) exhibited augmented WD-induced EV secretion with IL-1β and more significantly decreased the interaction of MVBs with lysosomes in the carotid arterial wall compared to their wild-type littermates (WT/WT). …”

Data_Sheet_1_Educational interventions to improve detection and management of cognitive decline in primary care—An Italian multicenter pragmatic study.PDF by Gemma Lombardi (12234914)

“…The number of visits per year performed by FPs increased, and the time interval between the first FP consultation and the diagnosis was optimized. Neuroleptic use significantly decreased, whereas the use of benzodiazepines remained steadily high. …”

DataSheet_1_YOLOv8-Peas: a lightweight drought tolerance method for peas based on seed germination vigor.pdf by Haoyu Jiang (5568554)

“…</p>Discussion<p>Our model effectively reduces deployment costs, improves detection efficiency, and provides a scientific theoretical basis for drought-resistant genotype screening in pea.…”

Image_4_Inhibition of CAL27 Oral Squamous Carcinoma Cell by Targeting Hedgehog Pathway With Vismodegib or Itraconazole.tif by Raíza Dias Freitas (9621278)

“…Vismodegib and itraconazole significantly reduced CAL27 cell viability after 48 h of treatment. …”

Table 2_SRC is a potential target of Arctigenin in treating triple-negative breast cancer: based on machine learning algorithms, molecular modeling and in Vitro test.xlsx by Yuezhou Huang (9998177)

“…Western blotting indicated that AG significantly reduced the levels of Bcl-2, caspase-3, and caspase-9, as well as decreased SRC, p-PI3K-p85, p-AKT1, p-MEK1/2, and p-ERK1/2 expression in TNBC cells in a concentration dependent manner.…”

Table 3_SRC is a potential target of Arctigenin in treating triple-negative breast cancer: based on machine learning algorithms, molecular modeling and in Vitro test.docx by Yuezhou Huang (9998177)

“…Western blotting indicated that AG significantly reduced the levels of Bcl-2, caspase-3, and caspase-9, as well as decreased SRC, p-PI3K-p85, p-AKT1, p-MEK1/2, and p-ERK1/2 expression in TNBC cells in a concentration dependent manner.…”

DataSheet_1_Unkeito promotes follicle development by restoring reduced follicle-stimulating hormone responsiveness in rats with polycystic ovary syndrome.docx by Sayako Yoshita (16999695)

“…The gene expression levels of FSHR and bone morphogenetic protein (BMP)-2 and BMP-6 were significantly decreased in the ovarian GCs of PCOS rats compared to those in normal rats. …”