Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria by Al-Sadeq, Duaa W.

“…This reduced activity is consistent with both in vitro and in silico evidence, which indicates that the L230Q mutation significantly decreases the overall protein’s stability, which in turn, may represent the underlying cause of its pathogenicity.…”
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Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy by Bhat, A.A.

“…Overall, this is a relatively unexplored field that could provide crucial insights into tumor immunology and encourage the effective application of modulatory cytokine-chemokine therapy to EC.…”
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Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP) by Hamad, Anas

“…Background: In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. However, the cancer-related burden on patients, healthcare systems, and the economy is expected to expand; thus, cancer remains a significant public healthcare issue in Qatar. …”
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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function by Da'as, Sahar I.

“…We recently showed that four arrhythmogenic CaM mutations (N98I, D132E, D134H, and Q136P) significantly reduce the binding of CaM to RyR2. Herein, we investigate in vivo functional effects of these CaM mutations on the normal zebrafish embryonic heart function by microinjecting complementary RNA corresponding to CaMN98I, CaMD132E, CaMD134H, and CaMQ136P mutants. …”
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Gender Prespecified Sampling for Cost Control by Trung Le1, Kien

“…Without accounting for these contextual factors, survey designers risk decreasing the representativeness of the sample through sampling and nonresponse errors. …”
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Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study by Rajesh, Sharma

“…Tracheal, bronchus, and lung cancer (both sexes), breast cancer (among females), colon and rectum cancer (both sexes), stomach cancer (both sexes) and prostate cancer (among males) were among top-5 cancers in most Asian countries in terms of ASIR and ASMR in 2019 and cancers of liver, stomach, hodgkin lymphoma and esophageal cancer posted the most significant decreases in age-standardized rates between 1990 and 2019. …”
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Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling by Ghantous, Crystal M.

“…Stretching the RPV also significantly increased ROS generation after 1 hour, whereas APN significantly decreased mechanical stretch-induced ROS production. …”
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Reduced vasorin enhances angiotensin II signaling within the aging arterial wall by Pintus, Gianfranco

“…The physical interaction between vasorin and TGF-β1 was significantly decreased in old vs. young VSMCs. Further, exposing young VSMCs to Ang II increased the levels of matrix metalloproteinase type II (MMP-2) activation and TGF-β1 downstream molecules p-SMAD-2/3 and collagen type I production up to the levels of old untreated VSMCs, and these effects were substantially inhibited by overexpressing vasorin. …”
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Novel electroless deposited corrosion — resistant and anti-bacterial NiP–TiNi nanocomposite coatings by Fayyad E.M.

“…Below and above this concentration as well as after the heat treatment, the improvement in the corrosion protection of the composite coatings slightly decreases. Besides, the NiP–TiNi NCCs have effective antibacterial properties as the cell viability of Escherichia coli decreases from 100 to 19%.…”
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Novel Electroless Deposited Corrosion - Resistant and Anti-Bacterial NiP-TiNi Nanocomposite Coatings by Fayyad, Eman

“…Below and beyond this concentration as well as after heat treatment, the improvement in the corrosion protection of the composite coatings slightly decreases. Besides, the NiP-TiNi NCCs have effective antibacterial properties as it decreased the cell viability of Escherichia coli from 100 to 19%.…”
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Silicon Enhances Morpho–Physio–Biochemical Responses in Arsenic Stressed Spinach (Spinacia oleracea L.) by Minimizing Its Uptake by Saleem, Muhammad Hamzah

“…Addition of Si into the soil significantly alleviated As toxicity effects on S. oleracea by improving photosynthetic capacity and ultimately plant growth. …”
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Network analysis of anxiety and depressive symptoms among quarantined individuals: Cross-sectional study by Abdul Karim, Mustafa

“…Results Participants with COVID-19 were significantly older and had a significantly higher proportion of males. …”
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Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway by Anwar, M. Akhtar

“…Here we determined the effects of an ethanolic extract of SF leaves on rings of isolated thoracic aorta from Sprague-Dawley rats. …”
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Electrochemical Investigation of C-Steel Corrosion Inhibition, In Silico, and Sulfate-Reducing Bacteria Investigations Using Pyrazole Derivatives by Shaban, Mahmoud M.

“…The current research shows important developments in producing highly effective anticorrosion and antimicrobial pyrazole derivatives.…”
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The Gender-Pay Gap and the Family in the Gulf: Root Causes, Implications and Policy Response by Al-Ahmadi, Hala

“…According to evidence it decreases family incomes and increases poverty. Although, women contribute significantly to the family's economic well-being, they continue to earn less than their male colleagues. …”
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High-intensity exercise training does not influence body weight but improves lipid oxidation in obese adults: A 6-week RCT by Jabbour, Georges

“…Moreover, for the training group, the homoeostasis model assessment of insulin resistance (HOMA-IR) index decreased significantly from the baseline value (p<0.01) and the control group value (p<0.01). …”
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COMBUSTION CHARACTERISTICS AND EMISSION OF A DI DIESEL ENGINE UTILIZING NEW INDUCTION MANIFOLD DESIGNS AND RUNNING ON ALTERNATIVE FUEL BLENDS by SADEQ, ABDELLATIF MOHAMMAD

“…The demands for increasing the swirl in the combustion chamber and for decreasing the exhaust emissions on diesel engines have increased rapidly over the past few years. …”
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Fabrication of hesperidin hybrid lecithin-folic acid silver nanoparticles and its evaluation as anti-arthritis formulation in autoimmune arthritic rat model. by Jabri, Tooba

“…Further, hybrid L-HP-FA-AgNPs suppressed the production of RANKL, OPG and MMP-2/9, which supported its anti-osteoclastic effects. Collectively, our data revealed that L-HP-FA-AgNPs significantly inhibited the progression of arthritis by reducing inflammationand bone damage. …”
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Chemical characterization and evaluation of antimicrobial and cutaneous wound healing potentials of gold nanoparticles using Allium saralicum R.M. Fritsch by Hu, X.

“…In vivo part, AuNPs ointment group raised significantly (p ≤ 0.01) the wound contracture, vessel, hydroxyl proline, hexuronic acid, fibrocyte, fibroblast, and fibrocytes/fibroblast rate and decreased significantly (p ≤ 0.01) the wound area, total cells, and lymphocyte compared to other groups in rats. …”
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S‐Fertilizer (Elemental Sulfur) Improves the Phytoextraction of Cadmium through Solanum nigrum L. by Alatawi, Aishah

“…The application of ES 100 mg kg−1 showed an effective approach to decreasing Cd uptake as compared to Gyp 100 mg kg−1. …”
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