Table1_A nonlinear relationship between systemic inflammation response index and short-term mortality in patients with acute myocardial infarction: a retrospective study from MIMIC... by Yufei Wang (171069)

“…Curve fitting showed a curvilinear relationship and further threshold saturation effects showed that, for 90-day mortality, each unit increased in ln-SIRI, when the ln-SIRI level is less than 2.9, the patient's mortality increases by 23.2% (OR: 1.232; 95% CI: 1.111–1.367; p < 0.001); when the ln-SIRI is greater than 2.9 and less than 4.6, the patient's mortality decreases by 44.4% (OR: 0.554; 95% CI: 0.392–0.789; p = 0.001); when ln SIR > 4.6, the patient's mortality increases by 24.7% (OR: 1.247; 95% CI: 1.108–1.404; p < 0.001). …”

Table_1_Efficacy and safety of immunotherapy combined with single-agent chemotherapy as second- or later-line therapy for metastatic non-small cell lung cancer.docx by Dongna Chen (16999068)

“…According to the receiver operating characteristics and Kaplan–Meier curve analyses, patients with high c-MET, EGFR, and VEGFR2 expression at baseline had significantly shorter PFS than those with low expression. …”

Table_1_Genomic, phenotypic and demographic characterization of Mycobacterium tuberculosis in Israel in 2021.xlsx by Yelena Losev (17198449)

“…The study highlights the need for ongoing surveillance of TB using molecular and phenotypic tools to further decreasing the spreading level of the disease and develop effective treatment strategies.…”

Table_1_Thalidomide Combined With Azathioprine as Induction and Maintenance Therapy for Azathioprine-Refractory Crohn's Disease Patients.DOCX by Tong Li (206968)

“…Both Crohn's Disease Endoscopic Index of Severity (13.4 ± 4.92 vs. 6.12 ± 5.24, P < 0.001) and Rutgeerts scores (3.23 ± 0.73 vs. 1.77 ± 1.59, P = 0.003) were significantly decreased with the use of combination therapy. …”

Image_10_Interaction between glycolysis‒cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer.pdf by Yan-Jie Chen (424920)

“…The opposite effects were obtained by GGH silencing. The phenotype associated with GGH was also validated in a xenograft nude mouse model.…”

Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging by Sulggi A. Lee (528197)

“…Whether chronic HIV infection causes similar effects is currently unclear.</p><p>Methods</p><p>We compared markers of CD8+ T cell differentiation (e.g., CD28, CD27, CCR7, CD45RA) and CD57 expression on CD28- CD8+ T cells in healthy HIV-uninfected adults with and without CMV infection and in both untreated and antiretroviral therapy (ART)-suppressed HIV-infected adults with asymptomatic CMV infection.…”

Supplementary Material for: Ibrutinib in Advanced Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Lower Risk of Hepatitis B Virus Reactivation by Yang S. (3704074)

“…Median duration of exposure to ibrutinib was significantly longer than exposure to rituximab (28 vs. 5 months). …”

Baclofen, a GABA_BR Agonist, Ameliorates Immune-Complex Mediated Acute Lung Injury by Modulating Pro-Inflammatory Mediators by Shunying Jin (147429)

“…Protective effects of baclofen treatment on ALI were possibly mediated by inhibition of TNF-α- and IL-1β-mediated inflammatory signaling. …”

Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization by Guochang Huang (381032)

“…Levels of neddylated Cul3 were decreased in <i>DCUN1D1</i>^<i>-/-</i> mice, and ubiquitinated proteins did not accumulate during the stages in which DCUN1D1 expression peaks during spermatogenesis in wild-type mice. …”

Image_1_Genomic, phenotypic and demographic characterization of Mycobacterium tuberculosis in Israel in 2021.tif by Yelena Losev (17198449)

“…The study highlights the need for ongoing surveillance of TB using molecular and phenotypic tools to further decreasing the spreading level of the disease and develop effective treatment strategies.…”

Datasheet1_Breathing pattern and pulmonary gas exchange in elderly patients with and without left ventricular dysfunction—modification with exercise-based cardiac rehabilitation an... by Prisca Eser (3873718)

“…From before to after exCR, resting VE decreased and peak P_ETCO₂ increased significantly more in patients with compared to without LVD. …”

The comparison of CHCA solvent compositions for improving LC-MALDI performance and its application to study the impact of aflatoxin B1 on the liver proteome of diabetes mellitus ty... by Fuu-Jen Tsai (230856)

“…In addition, major urinary protein 1 (MUP1), an indicator of increased insulin sensitivity, was significantly decreased in the T1DM/AFB1 group and may have resulted in higher blood glucose levels compared to the T1DM group. …”

High-resolution single cell analysis of persistently swimming trypanosomes. by Joel L. Bargul (555298)

“…<i>congolense</i> KETRI 3827 swimming in mouse blood (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005448#ppat.1005448.s015" target="_blank">S14 Video</a>), with a lower frequency than strain IL 1180, but with an apparently more effective waveform. H) <i>T</i>. <i>congolense</i> KETRI 3827 from infected sheep (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005448#ppat.1005448.s016" target="_blank">S15 Video</a>) beat with the same frequency as in mouse blood, but with significantly reduced forward swimming speed, showing the influence of the specific host environment. …”

CHDs-associated Nkx2.5 mutants displayed aberrant SUMO modification. by Eun Young Kim (132204)

“…The representative data from two independent assays were shown. D. Summary of the effects of Nkx2.5 missense mutations on sumoylation activity. …”

Flow chart of study selection. by Xu Han (141301)

“…The concentrations of BAs were adopted as the primary outcomes and the weighted mean differences (WMDs) and 95% confidence interval (CI) were generated by random-effects meta-analysis models.</p><p>Results</p><p>A total of 30 studies were enrolled which included 2313 participants and reported the 39 BAs or their ratios. …”

Increased paternal age at birth is negatively associated with overall variance in gene expression in peripheral blood lymphocytes (PBL) of normal children. by Mark D. Alter (139909)

“…For the evaluation of paternal age effects, paternal ages were available for 78 children with autism and 57 control children. …”

Data_Sheet_1_Normal Echocardiographic Reference Values of the Right Ventricular to Left Ventricular Endsystolic Diameter Ratio and the Left Ventricular Endsystolic Eccentricity Ind... by Sabrina Schweintzger (6633140)

“…</p>Methods<p>We conducted an echocardiographic study in 769 healthy children (median age: 3.36 years; range: 1 day—18 years) and validated abnormal values in 44 children with PH (median age: 2.1 years; range: 0.1 months—17.7 years). We determined the effects of gender, age, body length, body weight, and body surface area (BSA) on RV/LVes ratio and LVes EI values. …”

Data_Sheet_1_Traditional Chinese medicine prescriptions (XJZ, JSS) ameliorate spleen inflammatory response and antioxidant capacity by synergistically regulating NF-κB and Nrf2 sig... by Jian Chen (15340)

“…By hematoxylin and eosin staining, hematological analysis, flow cytometric analysis, qRT-PCR and western blot, the effects of both TCM prescriptions on the spleen antioxidant defense system and inflammatory pathway were explored. …”

Image_1_Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation.tif by Kaixiang Xu (4571833)

“…Phenotyping data showed that the mRNA expressions of triple genes and protein expressions of B2M and CIITA genes were still detectable and comparable with wild-type (WT) pigs in multiple tissues, but α1,3-galactosyltransferase was eliminated, SLA-I was significantly decreased, and four subtypes of SLA-II were absent in GBC-modified pigs. …”

Data_Sheet_1_Multiple treatment interruptions and protecting HIV-specific CD4 T cells enable durable CD8 T cell response and viral control.PDF by Anshika Jain (8037536)

“…<p>Human Immunodeficiency Virus (HIV) remains a global health challenge, and novel approaches to improve HIV control are significantly important. The cell and gene therapy product AGT103-T was previously evaluated (NCT04561258) for safety, immunogenicity, and persistence in seven patients for up to 180 days post infusion. …”