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effects decrease » effects decreased (Expand Search), effects regress (Expand Search)
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20641
Table 2_PCP4 inhibits the progression of prostate cancer through Ca2+/CAMKK2/AMPK/AR pathway.xlsx
Published 2025“…</p>Conclusion<p>Our findings elucidate the molecular mechanism that PCP4 downregulation promotes PCa progression via Ca<sup>2+</sup>/CAMKK2/AMPK/AR pathway, highlighting its significance in CRPC development.</p>…”
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20642
Table 1_Case Report: Identification of a novel hemizygous CFAP47 variant in a primary ciliary dyskinesia patient with dual ciliary and flagellar defects.docx
Published 2025“…Experimental validation revealed significantly decreased CFAP47 mRNA levels in the patient’s sperm and the HEK293 cells transfected with mutant plasmid compared to controls, suggesting impaired transcript stability.…”
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20643
Table 1_Declining trends in sweetness of the diet in the United Kingdom: 2008/9–2018/19.docx
Published 2025“…Overall, the decline in ASE was larger for beverages than foods (ASE values declined 20.7% for beverages vs. 4.4% for foods), although both decreased significantly (p-value < 0.01). Dietary sweetness has changed in the UK, due to a combination of consumer behavior, reformulations, policies, public health awareness programs, and media campaigns, emphasizing its multifactorial nature.…”
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20644
Data Sheet 1_Dual upregulation of miRNA-143 and miRNA-506 in non-small cell lung cancer inhibits proliferation, motility, migration, and tumor growth.pdf
Published 2025“…The dual miR upregulation increased the G2 phase cell population and decreased cell proliferation, motility, migration, and colony formation. …”
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20645
Image 1_Multi-omics analysis reveals that low cathepsin S expression aggravates sepsis progression and worse prognosis via inducing monocyte polarization.jpeg
Published 2025“…Inflammatory markers (p < 0.05) and migration ability of LPS-activated monocytes were significantly reduced after CTSS agonist. In addition, CTSS agonist decreased the pulmonary tissue monocyte/macrophages infiltration in septic mice.…”
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20646
Image 5_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le...
Published 2025“…Furthermore, 29 out of 47 differential metabolites significantly correlated with the eight dominant microbial genera. …”
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20647
Data Sheet 1_Influence of the polysaccharide capsule on virulence and fitness of Klebsiella pneumoniae.pdf
Published 2025“…Infections of Galleria mellonella larvae showed a significantly decreased virulence potential of the CPS-deficient mutant.…”
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20648
Image 2_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le...
Published 2025“…Furthermore, 29 out of 47 differential metabolites significantly correlated with the eight dominant microbial genera. …”
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20649
Data Sheet 1_GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma.pdf
Published 2024“…The expression of G protein–coupled estrogen receptor 1 (GPER1), a non-classical estrogen receptor, was significantly decreased in proliferating macrophages, and was inversely correlated with macrophage proliferation in HCC tumors. …”
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20650
Image 14_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg
Published 2025“…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…”
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20651
Table 1_Integrative multi-omics analysis and experimental validation identify molecular subtypes, prognostic signature, and CA9 as a therapeutic target in oral squamous cell carcin...
Published 2025“…In vitro experiments validated CA9 as a promising therapeutic target, with its knockdown significantly inhibiting OSCC cell proliferation and migration.…”
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20652
Image 5_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.tif
Published 2025“…Wheat seed inoculation significantly enhanced germination metrics, seedling vigor, and altered carbohydrate metabolism in the seed endosperm. …”
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20653
Table 1_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le...
Published 2025“…Furthermore, 29 out of 47 differential metabolites significantly correlated with the eight dominant microbial genera. …”
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20654
Bgh/GelMA/CMCS hydrogel with bone MSC-EVs for lunate defect repair
Published 2025“…In vivo, the M1/M2 ratio and inflammatory factors decreased significantly one-week post-implantation, while CD31 and VEGF-positive cells increased at four weeks, and BMP2 and OPN-positive cells at eight weeks. …”
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20655
Disruption of Astrocyte Communication by Carbenoxolone During Shockwave-Induced Stress
Published 2025“…Peak calcium intensity was significantly reduced at 100 µM CBX, and both rise and fall rates of calcium signals decreased with increasing CBX concentration. …”
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20656
Supplementary file 1_Metabolic insights into hypoxia adaptation in adolescent athletes at different altitudes: a cross-sectional study.docx
Published 2025“…Lipid metabolism was significantly altered in moderate-altitude athletes, including pathways such as linolenic and linoleic acid, sphingolipid, and arachidonic acid, as well as processes involving the transfer of acetyl groups into mitochondria and fatty acid biosynthesis. …”
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20657
Image 2_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.tif
Published 2025“…Wheat seed inoculation significantly enhanced germination metrics, seedling vigor, and altered carbohydrate metabolism in the seed endosperm. …”
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20658
The structure of IRAU and Res2Net+ block [22].
Published 2025“…However, after removing the integrated residual attention unit and depth-wise separable convolution, the accuracy decreased by 1.91% and the latency increased by 117ms. …”
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20659
Table 1_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.xlsx
Published 2025“…Wheat seed inoculation significantly enhanced germination metrics, seedling vigor, and altered carbohydrate metabolism in the seed endosperm. …”
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20660
Table 1_The impact of tumor burden score on prognosis in patients after radical resection of hepatocellular carcinoma: a single-center retrospective study.docx
Published 2024“…</p>Conclusion<p>In patients undergoing radical resection for HCC, higher TBS was significantly related to shorter OS and RFS.</p>…”