Negative (Prednisone) and basal (ATP) control compounds binding to ALK protein. حسب Richard Junior Zapata Dongo (17912565)

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S1 Data - حسب Richard Junior Zapata Dongo (17912565)

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ALKG1202R –ABT199 interactions. حسب Richard Junior Zapata Dongo (17912565)

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ALKC1156Y –ABT199 interactions. حسب Richard Junior Zapata Dongo (17912565)

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ALKL1196M –ABT199 interactions. حسب Richard Junior Zapata Dongo (17912565)

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ALK^wt–ABT199 interactions. حسب Richard Junior Zapata Dongo (17912565)

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ALK inhibitors (Positive control) and ABT199 (Proposed binding) in complex with the ALK active side. حسب Richard Junior Zapata Dongo (17912565)

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Enrichment analysis of genes from the significant MS module. حسب Lai Jiang (2401513)

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Table 1_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 3_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 4_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 8_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 2_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 6_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 5_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 7_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Table 9_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.xlsx حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Data Sheet 1_Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity.docx حسب Stefanie Hoffmann (3756733)

"…In parallel the cell viability was determined after 24 h to be able to distinguish between an unspecific cytotoxic effect or direct tight junction damage. Overall, from the 23 tested compounds, 15 showed the expected outcome, i.e., the compound led to a decrease of the TEER for the positive control compounds, or the TEER value remained stable after treatment with non-GI-toxic compounds.…"

Image 3_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.tif حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"

Image 1_Absolute abundance calculation enhances the significance of microbiome data in antibiotic treatment studies.tif حسب Stefanie Wagner (743707)

"…Standard 16S rRNA gene amplicon sequencing of microbiota samples offers compositional data in relative, but not absolute abundancies, and the presence of multiple copies of 16S rRNA genes in bacterial genomes introduces bias into compositional data. We explored whether improved sequencing data analysis influences the significance of the effect exerted by antibiotics on the faecal microbiota of young pigs using two veterinary antibiotics. …"