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321
Environmental enrichment and cafeteria diet synergistically modify the response to chronic variable stress in rats
Published 2013“…In addition, there was a significant interaction between diet and EE (P=0.02) on serum CORT levels: the CVS-induced increase in CORT was attenuated in the presence of EE and the CAF diet independently and in a synergistic manner. …”
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322
Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
Published 2021“…<p dir="ltr">Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. …”
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323
Analysis of the Qatari healthcare system
Published 2015“…This contrasts previous with studies of immigrants in the USA and Europe, who typically face significant barriers to healthcare, and this is likely because many of the non-Qataris are highly educated high income professionals. …”
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324
Application of Cyanobacteria (Roholtiella sp.) Liquid Extract for the Alleviation of Salt Stress in Bell Pepper (Capsicum annuum L.) Plants Grown in a Soilless System
Published 2021“…Moreover, chlorophyll a and b increased significantly compared with seedlings sprayed with water. …”
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325
DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
Published 2000“…However, when ultrasound was applied, a rapid and significant increase in DNA damage was observed (P=0.0001). …”
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326
Andrographolide pre-treatment enhances the anti-tumor activity of topotecan on acute myeloid leukemia cells in vitro
Published 2016“…Results: When applied separately, topotecan and andrographolide both exhibited anti-proliferative effects in a dose-dependent manner. Cotreating the cells with both topotecan and andrographolide simultaneously at various concentrations did not result in any significant changes. …”
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327
The Integration of Agile Methodology in the Development of Software Project
Published 2024“…Agile proponents have produced a number of assertions regarding the advantages of agile approaches, such as increased group productivity and effectiveness, improved software reliability, and business effectiveness. …”
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328
Tranexamic Acid for Traumatic Injury in the Emergency Setting: A Systematic Review and Bias-Adjusted Meta-Analysis of Randomized Controlled Trials
Published 2024“…Study objectiveTraumatic injury causes a significant number of deaths due to bleeding. Tranexamic acid (TXA), an antifibrinolytic agent, can reduce bleeding in traumatic injuries and potentially enhance outcomes. …”
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329
Measuring LEED–NC applicability in design for hospitality
Published 2015“…Research was conducted to determine precisely which green building innovations present the most significant barriers to incorporating sustainability into design for hospitality. …”
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330
Potential Medical Applications of Chitooligosaccharides
Published 2022“…COS can be produced through enzymatic conversions using chitinases, physical and chemical applications, or a combination of these strategies. COS is of significant interest for pharmacological and medical applications due to its increased water solubility and non-toxicity, with a wide range of bioactivities, including antibacterial, anti-inflammatory, anti-obesity, neuroprotective, anticancer, and antioxidant effects. …”
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331
Narratives of internal migration experiences, health/well-being issues among females working as head-porters (Kayayei) in Ghana
Published 2020“…Findings– The results revealed the geographic, structural and family issues that promote increased migration of females to the cities. The findings betray the potential negative effects of migration on the participants’ quality of life, including accessing health services. …”
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332
Melt processing and properties of linear low density polyethylene-graphene nanoplatelet composites
Published 2016“…However, this effect is not significant for the electrical conductivity and tensile strength. …”
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333
Mitigation of Greenhouse Gas Emissions from Agricultural Fields through Bioresource Management
Published 2022“…Soil moisture was also impacted by soil temperature and rainfall events. There was a significant effect of events of data collection, i.e., the length of the growing season (p-value ≤ 0.05) on soil surface temperature, leading to increased GHG emissions during the summer months. …”
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334
Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
Published 2019“…Cells were co-transfected with a C-terminal modified α-synuclein (SynT) and synphilin-1, and then treated with DHM (10 μM) and Sal B (50 μM) 16 hours after transfection; levels of α-synuclein aggregation decreased significantly (68% for DHM and 75% for Sal B). Concomitantly, we detected increased levels of LAMP-1 (a marker of lysosomal homeostasis) and LAMP-2A (a key marker of CMA). …”
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335
Natural products as chemo-radiation therapy sensitizers in cancers
Published 2022“…Unfortunately, treatment failure due to intrinsic and acquired resistance to the current CT and RT is a significant challenge associated with poor patient prognosis. …”
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336
<i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells
Published 2022“…Interestingly, apoptosis was mediated by a significant loss of mutant p53 protein, and increased Bax/Bcl2 ratio. …”
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337
How does varying the number of personas affect user perceptions and behavior? Challenging the ‘small personas’ hypothesis!
Published 2022“…Our study results from eye-tracking and survey data suggest that when using interactive persona systems, the number of personas can be increased from the conventionally suggested ‘less than ten’, without significant negative effects on user perceptions or task performance, and with the positive effects of increasing engagement with the personas, having a more diverse representation of the end-user population, as well as users accessing personas from more varied demographic groups for a design task. …”
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Eradication of hepatitis C virus infection in kidney transplant recipients using direct‐acting antiviral therapy: Qatar experience
Published 2020“…<h3>Introduction</h3><p dir="ltr">Hepatitis C virus (HCV) infection has detrimental effects on patient and graft survival after kidney transplantation. …”
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340
Giving cancer patients the support they need
Published 2016“…This percentage is expected to increase ten-fold by 2050, which could have significant implications for cancer care.…”