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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Mathematical Model-Based Optimization of Continuous Flow Photobioreactor Operating at Steady State Using MATLAB Optimization Function
منشور في 2024"…The objective of this work is to optimize continuous flow PBR at steady state using a mathematical model describes growth of the microalgae species<i> Chlorella vulgaris</i>. …"
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Trade Flow and Nation Brand Distance: A Structural Gravity Model Approach
منشور في 2021"…The empirical findings shows that NBD influence both export and import volume in which less distant countries in term of nation brands are able to overcome the negative effect of geographical distance which can stimulates the export mainly and import flow to some extent. The results on the impact of NBD on FTA and trade flows provides some interesting insights as the there is a negative and significant moderation impact of NBD on the relationship between FTA and both export and import volume which suggest that a decrease of NBD will increase the effect of FTA on trade flow. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Characterization of the dynamic flow response in microfluidic devices
منشور في 2024احصل على النص الكامل
doctoralThesis -
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A hybrid model to predict the pressure gradient for the liquid-liquid flow in both horizontal and inclined pipes for unknown flow patterns
منشور في 2023"…The proposed hybrid scheme can significantly reduce the costs associated with identifying the oil-water flow profile and be critical in designing energy-efficient transportation of liquid-liquid flow.…"
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Performance Evaluation of a New Fluorescent-Based Lateral Flow Immunoassay for Quantification of Hemoglobin A1c (HBA1c) in Diabetic Patients
منشور في 2023"…Recently, fluorescent-based lateral flow immunoassays (LFIAs) gained wide attention for small laboratories and population surveillance. …"
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Semi-analytical Model to Predict Dynamic Capillary Pressure–Saturation Relationship for Flows in Heterogeneous Porous Media
منشور في 2024"…In this paper, we develop a first of a kind semi-analytical model to predict the capillary pressure–saturation curves during drainage displacement by integrating the dynamics of fluid flow based on fundamental laws of fluid mechanics. …"
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A simplified model for unsteady pressure driven flows in circular microchannels of variable cross-section
منشور في 2018"…In this paper, we present a fast and accurate model for unsteady pressure-driven flows in circular microchannels of variable cross-section. …"
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Evidence and gaps in clinical outcomes of novel pharmacologic therapies for sickle cell disease: A systematic literature review highlighting insights from clinical trials and real-...
منشور في 2025"…Real-world studies of crizanlizumab showed a reduction in complicated VOC events. The high discontinuation rate and results of the STAND trial led to a significant decrease in the use of crizanlizumab. …"