Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice by Ayman Alzu'bi (18192898)

“…Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. …”

Beauvericin potentiates the activity of pesticides by neutralizing the ATP-binding cassette transporters in arthropods by Charbel Al Khoury (13167975)

“…Consequently, resistant pests reduce the yield of agricultural production, causing significant economic losses and reducing food security. …”

Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation by Salman, Zeina

“…Functional assays revealed that miR-222-5p overexpression led to a significant increased expression of key pro-inflammatory cytokines, including IL-8 and TNF-α, while knockdown of these miRNAs resulted in their decreased expression. …”
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The effect of type and combination of fertilizers on eukaryotic microbiome of date palm rhizosphere by Sara H. Al-Hadidi (17821196)

“…We conclude that cultivar type (biotic factor), type of fertilizer, and dosage (abiotic factor) play significant roles in determining the microbiome diversity of the rhizosphere. …”

Genetic Basis and Prognostic Value of Exercise QT Dynamics by Stefan van Duijvenboden (7116386)

“…We also did not observe associations of QT dynamics during exercise and recovery with cardiovascular events. Increased QT dynamics during recovery was significantly associated with all-cause mortality in the univariate Cox regression analysis (hazard ratio, 1.09 [95% CI, 1.05–1.13], P =2.28×10 -5 ), but the association was not significant after adjusting for clinical risk factors.…”

A jojoba (Simmondsia chinensis) seed cake extracts express hepatoprotective activity against paracetamol-induced toxicity in rats by Firas Feki (17545638)

“…After enzyme treatment, simmondsin content decreased from 33.0 % to 3.0 % and glucose content increased from 16.2 % to 27.3 % reflecting simmondsin hydrolysis. …”

Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications by Fang Yu (156838)

“…</p> <h2>Key points</h2> <ul> <li>A floxed stromal interaction molecule 1 (STIM1) hypomorph mouse model was generated with significant reduction in Ca²⁺ influx through store-operated Ca²⁺ entry (SOCE), resulting in defective nuclear translocation of nuclear factor of activated T cells, cytokine production and inflammatory response. …”

Biochemical Characterization of Halotolerant Bacillus safensis PM22 and Its Potential to Enhance Growth of Maize under Salinity Stress by Muhammad Atif Azeem (17542080)

“…Additionally, inoculation of the halotolerant bacteria PM22 reduced the severity of salinity stress in plants and increased root and shoot length at various salt concentrations (0, 180, 240, and 300 mM). …”

Recovery of business intelligence systems by Haraty, Ramzi A.

“…The execution time of the recovery process is a crucial factor for measuring the performance because it is directly proportional to the denial of service time of any healthcare system. …”
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Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... by Marissa B Reitsma (8674341)

“…Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. …”

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 by Gregory A. Roth (6302315)

Mutational landscape of aggressive cutaneous squamous cell carcinoma by Saade, Rami E.

“…Experimental Design: Whole exome sequencing was performed on 39 cases of aggressive cSCC to identify driver genes and novel therapeutic targets. Significantly mutated genes were identified with MutSig or complementary methods developed to specifically identify candidate tumor suppressors based upon their inactivating mutation bias. …”
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Bacillus thuringiensis strain QBT220 pBtoxis plasmid structural instability enhances δ-endotoxins synthesis and bioinsecticidal activity by Kavita Nair (17151127)

“…However, when compared with the <i>Bti</i> reference strains H14 and QBT217 that carry all δ-endotoxins coding genes, it was found that QBT220, has a significantly higher insecticidal activity against the dipteran insect <i>Aedes aegypti</i> larvae despite of the plasmid pBtoxis structural instability due to the alteration of <i>cry10A</i> and <i>cyt1C</i> genes. …”

On the benefits of sleep by Nature Research (16552612)

“…People who work nights are exposed to artificial light, and this significantly affects the expression of “clock genes” that synchronize body functions to the day–night cycle. …”

Whole-genome Sequences of Multidrug-Resistant Escherichia coli by Khodor, Ragheed R.

“…In silico analysis was used to determine the resistance genes, virulence factors, Inc groups, and O and H serotypes. …”
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The distribution of toxic sources in Louisiana by Djoundourian, Salpie Sarkis

“…The results reveal that income levels in communities that host toxic sources are consistently and significantly lower than the state averages. A distance gradient analysis indicates that as distance from the nearest toxic source increases, the mean percentage of blacks in the community decreases and the mean percentage of whites increases. …”
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A population study of clinically actionable genetic variation affecting drug response from the Middle East by Puthen Veettil Jithesh (12040358)

“…The allele frequencies of 1,320 variants in 703 genes affecting 299 drugs or class of drugs were significantly different between the Qatari population and other world populations. …”

Water-pipe smoking promotes epithelial–mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways by Khaled W. Sadek (14153196)

“…More significantly, WPS provokes a down- and up-regulation of E-cadherin and focal adhesion kinase (FAK), respectively, which are important key regulators of cancer progression genes. …”

Phosphorus supplement alters postprandial lipemia of healthy male subjects by Bassil, Maya

“…Changes in different parameters were analyzed using a 2-factor repeated-measure ANOVA. In the phosphorus (P) supplemented group, postprandial serum P increased (p = 0.00), while changes in insulin, non-esterified fatty acids (NEFA) and triglyceride (TG) were not significantly different than that of placebo. …”
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Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema by Diab, Khalil J.

“…Administration of sphingosine decreased the ceramide-to-S1P ratio in the lung and inhibited alveolar space enlargement, along with activation of prosurvival signaling pathways and decreased lung parenchyma cell apoptosis. …”
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