PPI network analysis. حسب Du Leng (20421711)

Juvenile demyelination induces a loss of functional autapses. حسب Sara Hijazi (21656615)

"…Cuprizone-treated mice show a significant decrease in the percentage of cells showing an autaptic response (<i>Fisher’s exact test; *p = 0.0173</i>). …"

AUT00201 (1 µM) can rescue AP width in cuprizone mice. حسب Sara Hijazi (21656615)

"…In the responsive cells from cuprizone mice (red) a significant increase in PV interneuron firing frequency at lower current steps (gray) was observed (<i>group x current two-way repeated measures: n = 8 cells from 4 mice: p = 0.05287; AUT00201 effect: F(1,60) = 5.050, *p = 0.0457. …"

Autapses play a crucial role in PV interneuron’s sustained firing at high frequencies. حسب Sara Hijazi (21656615)

"…Average action potential (AP) frequency in response to 0−650 pA current steps illustrating a significant increase in PV interneuron firing frequency at low-current steps in control cells without autapses (gray) compared to control cells with autapses (black). …"

Comparison between juvenile and adult demyelination. حسب Sara Hijazi (21656615)

"…Juvenile demyelination leads to impairment in PV interneuron maturation whereas adult demyelination induces a decrease in the excitability of PV interneurons. Summary data showing the averaged (± s.e.m) of the following intrinsic properties: (A) Resting membrane potential (RMP) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: *p < 0.05, **p < 0.01, ****p < 0.0001</i>), (B) Input resistance (IR) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0024, post-hoc LSD test: *p < 0.05, **p < 0.01, ***p < 0.001</i>), (C) Sag (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0083, post-hoc LSD test: *p < 0.05, **p < 0.01</i>), (D) Rheobase (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, p = 0.1230, post-hoc LSD test: *p < 0.05</i>) and (E) Action potential (AP) threshold (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, *p = 0.0452, post-hoc LSD test: *p < 0.05</i>), (F) AP half-width (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0058, post-hoc LSD test: **p < 0.01</i>), (G) Average action potential (AP) frequency in response to 0–650 pA current steps illustrating no significant change in S1 PV interneuron firing frequency following juvenile demyelination (<i>group x current two-way repeated measures: n = 36,30,19,24 cells from 9/8/8/6 mice per group: F(39,1,291) = 2.487, ****p < 0.0001</i>) and (H) Maximum firing frequency per group (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: ***p < 0.001, ****p < 0.0001</i>). …"

The UL4 null mutation alleviates inflammasome activation in PRV-infected cells. حسب Xiaohua Zhang (350570)

The UL4 mutation alleviates inflammasome activation and pyroptosis in PRV-infected cells. حسب Xiaohua Zhang (350570)

Multiscale QM/MM Simulations Identify the Roles of Asp239 and 1‑OH···Nucleophile in Transition State Stabilization in Arabidopsis thaliana Cell-Wall Invertase 1 حسب Wijitra Jitonnom (22410515)

"…The glycosylation and deglycosylation steps were considered in both wild type and mutants. …"

Probe IDs for protein EpiScore. حسب Atchara Dawangpa (16560735)

"…Additionally, the overweight group experienced significant reductions in methylation levels at eight lipogenesis-related genes. …"

Flow chart of study design. حسب Atchara Dawangpa (16560735)

"…Additionally, the overweight group experienced significant reductions in methylation levels at eight lipogenesis-related genes. …"

ELISA of the key proteins. حسب Du Leng (20421711)

"…Ten DEGs (ITGA5, ITGA4, ENG, MMP14, SERPINH1, THY1, TAGLN, ITGA1, IGF1, and ITGB5) were considered target genes according to PPI network analysis. ELISA showed a slight decrease in the serum levels of CDK1, ITGA5, ITGB5, and CD44 during and after treatment.…"

Increased basophils in blood of calves diagnosed with BRD by Wisconsin health scoring. حسب Cian Reid (17274007)

Elevated levels of IL-8 protein expression in unstimulated whole blood of BRD diagnosed calves. حسب Cian Reid (17274007)

Table 3_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx حسب Joanna Palade (17712960)

"…Introduction<p>Immune-based agents, especially Immune Checkpoint Inhibitors (ICI), are standard of care therapy in non-small cell lung cancers (NSCLC); however, a significant number of patient tumors fail to respond, or develop resistance. …"

Table 7_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx حسب Joanna Palade (17712960)

"…Introduction<p>Immune-based agents, especially Immune Checkpoint Inhibitors (ICI), are standard of care therapy in non-small cell lung cancers (NSCLC); however, a significant number of patient tumors fail to respond, or develop resistance. …"

Image 1_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.jpg حسب Joanna Palade (17712960)

"…Introduction<p>Immune-based agents, especially Immune Checkpoint Inhibitors (ICI), are standard of care therapy in non-small cell lung cancers (NSCLC); however, a significant number of patient tumors fail to respond, or develop resistance. …"

Table 8_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx حسب Joanna Palade (17712960)

"…Introduction<p>Immune-based agents, especially Immune Checkpoint Inhibitors (ICI), are standard of care therapy in non-small cell lung cancers (NSCLC); however, a significant number of patient tumors fail to respond, or develop resistance. …"

Table 4_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx حسب Joanna Palade (17712960)

"…Introduction<p>Immune-based agents, especially Immune Checkpoint Inhibitors (ICI), are standard of care therapy in non-small cell lung cancers (NSCLC); however, a significant number of patient tumors fail to respond, or develop resistance. …"

Table 6_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx حسب Joanna Palade (17712960)

"…Introduction<p>Immune-based agents, especially Immune Checkpoint Inhibitors (ICI), are standard of care therapy in non-small cell lung cancers (NSCLC); however, a significant number of patient tumors fail to respond, or develop resistance. …"

Table 2_NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer.xlsx حسب Joanna Palade (17712960)

"…Introduction<p>Immune-based agents, especially Immune Checkpoint Inhibitors (ICI), are standard of care therapy in non-small cell lung cancers (NSCLC); however, a significant number of patient tumors fail to respond, or develop resistance. …"