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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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GIS-BIM Based Regional Seismic Risk Assessment for Dubai, UAE
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A pathway to 25% reduction in greenhouse gas emission by 2030 using GIS-Based multi-criteria decision making for renewables, date palm (phoenix dactylifera), and carbon credits: a...
Published 2024“…Also, while Qatar has the potential to meet 20% of its energy demand by 2030 from renewable sources by using solar PV and wind, this will only account for a 14.28% reduction in overall emissions. Additionally, planting date palm trees (Phoenix dactylifera) would significantly benefit the nation in the area of carbon sequestration and revenue generation as compared to purchasing carbon offset credits.…”
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Development of a Smart System for Leak Detection in Water Distribution Networks
Published 2021Get full text
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Could Petrol Stations Play a Key Role in Transportation Electrification? A GIS-Based Coverage Maximization of Fast EV Chargers in Urban Environment
Published 2022“…More specifically, the location problem is modelled as a maximum coverage location problem (MCLP) and solved using a geographic information system (GIS) based platform. The spatial optimization problem is solved using a linear-programming relaxation based MCLP algorithm developed in Python. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Land suitability assessment and self-sufficiency evaluation for fodder crop production in a hyper arid environment coupling GIS-based multi-criteria decision making and optimizatio...
Published 2025“…Analytic Hierarchy Process and GIS-based multi-criteria approaches are used to calculate the weights of evaluation criteria and generate suitability maps. …”
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Hemodynamics of small aneurysm pairs at the internal carotid artery
Published 2012“…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.…”
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Identification of potential managed aquifer recharge sites in hyper-arid environment using GIS and analytical hierarchy process
Published 2025“…The success of managed aquifer recharge (MAR) relies on the assessment and modeling of site-specific hydrogeological characteristics, including groundwater salinity, transmissivity, storativity, slope, soil properties, proximity to water recharge networks and road accessibility, etc. This study employs a GIS-based multi-criteria evaluation technique, integrating both ground and remote sensing datasets. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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The Development And Significance Of Business Intelligence (BI) Platforms In Facilitating The Decision-Making Process In Dubai Government Entities
Published 2022“…A BI platform using ArcGIS software is also developed demonstrating the visual and realistic application of interactive data in decision-making regarding different aspects of DSC such as population, marriages, education, etc. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
