Showing 121 - 140 results of 5,443 for search '(( significant gram based ) OR ( significant ((teer decrease) OR (greater decrease)) ))', query time: 0.73s Refine Results
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    Dataset. by Reenu Thomas (16184560)

    Published 2024
    “…Extended spectrum beta-lactamase Gram-negative isolates are being replaced by carbapenem resistance, with around one third of all significant Gram-negative isolates now carbapenem resistant. …”
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    Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria by Colin K. Skepper (1897093)

    Published 2020
    “…Herein we describe the discovery and optimization of a series of 4-(aminomethyl)­quinolin-2­(1<i>H</i>)-ones, exemplified by <b>34</b>, that inhibit bacterial DNA gyrase and topoisomerase IV and display potent activity against ciprofloxacin-resistant Gram-negative pathogens. X-ray crystallography reveals that <b>34</b> occupies the classical quinolone binding site in the topoisomerase IV-DNA cleavage complex but does not form significant contacts with residues in the quinolone resistance determining region.…”
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    Data Sheet 1_Understanding the selectivity in silico of colistin and daptomycin toward gram-negative and gram-positive bacteria, respectively, from the interaction with membrane ph... by Yesid Aristizabal (21731441)

    Published 2025
    “…<p>Antimicrobial resistance is a significant public health concern worldwide. Currently, infections by antibiotic-resistant Gram-negative and Gram-positive bacteria are managed using the lipopeptide antibiotics colistin and daptomycin, which target the microbial membrane. …”
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