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Dystrophic neurites relative to Aβ42 are not reduced by nimodipine treatment.
Published 2022“…C) When plaques were stratified by area of Aβ42 staining, we found a clear correspondence between the size of the Aβ42 region and the ratio of LAMP1:Aβ42, with smaller plaques having higher ratios, indicating a proportionally greater amounts of dystrophic neurites. The decrease in LAMP1:Aβ42 ratio with increasing Aβ42 area was similar between vehicle and nimodipine-treated mice, with no significant differences between the two groups for any size range of plaques. …”