يعرض 61 - 80 نتائج من 34,875 نتيجة بحث عن '(( significant herg based ) OR ( significant ((we decrease) OR (nn decrease)) ))', وقت الاستعلام: 1.47s تنقيح النتائج
  1. 61

    Enlarged Data Sets and Innovative Applicability Domain Characterization Empower ML Models to Reliably Bridge hERG Binding Data Gaps in Diverse Chemicals حسب Yuxuan Zhang (1425721)

    منشور في 2025
    "…The optimal model constrained by the AD<sub>SAL</sub> achieved a coefficient of determination up to 0.89 on the external-validation set, which significantly outperformed previous models. The model coupled with the AD<sub>SAL</sub> constraint was applied to predict hERG binding affinities for more than 100,000 chemicals from multiple inventories, identifying over 5,000 potential hERG blockers. …"
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    Supplemental data_Role of transient receptor potential vanilloid 4 in therapeutic anti-fibrotic effects of pirfenidone حسب Koji Kuronuma (9638138)

    منشور في 2021
    "…Finally, we showed that changes in forced vital capacity of patients with IPF treated with pirfenidone were significantly correlated with metabolite levels of TRPV4 endogenous ligands in bronchoalveolar lavage fluid. …"
  3. 63

    Supporting information_Role of transient receptor potential vanilloid 4 in therapeutic anti-fibrotic effects of pirfenidone حسب Koji Kuronuma (9638138)

    منشور في 2021
    "…Finally, we showed that changes in forced vital capacity of patients with IPF treated with pirfenidone were significantly correlated with metabolite levels of TRPV4 endogenous ligands in bronchoalveolar lavage fluid. …"
  4. 64

    Role of transient receptor potential vanilloid 4 in therapeutic anti-fibrotic effects of pirfenidone حسب Koji Kuronuma (9638138)

    منشور في 2020
    "…Finally, we showed that changes in forced vital capacity of patients with IPF treated with pirfenidone were significantly correlated with metabolite levels of TRPV4 endogenous ligands in bronchoalveolar lavage fluid. …"
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    Interaction strength in plant-pollinator networks: Are we using the right measure? حسب Roberto Novella-Fernandez (8119745)

    منشور في 2019
    "…Interaction evenness also decreased strongly with the visit-based approach. We conclude that accounting for the number of flowers visited per encounter provides a more ecologically relevant measure of interaction strength. …"
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    Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket حسب Lilia Leisle (11356934)

    منشور في 2021
    "…We confirmed experimentally that the interaction is predominantly driven by electrostatic forces, and using noncanonical amino acids as photo-cross-linkers, we identified 16 residues in ASIC1a contributing to Big Dyn binding. …"
  11. 71

    Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket حسب Lilia Leisle (11356934)

    منشور في 2021
    "…We confirmed experimentally that the interaction is predominantly driven by electrostatic forces, and using noncanonical amino acids as photo-cross-linkers, we identified 16 residues in ASIC1a contributing to Big Dyn binding. …"
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