Showing 1 - 20 results of 74,503 for search '(( significant hits (increase OR increased) ) OR ( significant a decrease ))', query time: 1.51s Refine Results
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    Validation of primary screen hits reveals compounds that recapitulate increased spheroid size (swell) or decreased MUC5AC in the lumen. by Pranjali Beri (14945400)

    Published 2023
    “…Compounds that appeared to cause toxicity were identified by observing a significant decrease in spheroid counts in the swell readout or a significant decrease in the total nuclear intensity of the MUC5AC ratio readout. …”
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    Global representation of increased sensitivity of the MV model. by George Nicholson (106301)

    Published 2022
    “…For effective visualisation, only a random subset of 500 KO lines is shown. The heatmaps display scaled <i>z</i>-statistics, so that and correspond to a gene KO causing a significant increase/decrease respectively in the phenotype (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001723#sec014" target="_blank">Methods</a>–<i>Control of error rates</i>). …”
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    Increased carrying capacity reduces the benefit of adaptive therapy by reducing spatial competition. by Masud M A (12219010)

    Published 2022
    “…S2A Fig shows that increasing the carrying capacity significantly decreased the TG (<i>p</i> − <i>value</i> < 0.001) from a median of 139 days to a median of 7 days. …”
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    Spheroid size changes due to primary mucus reduction hits and mucus changes due to primary swell hits. by Pranjali Beri (14945400)

    Published 2023
    “…Compounds 56 (1μM), 85 (10μM), and 294 (1 and 10μM) significantly increased MUC5AC ratio compared to DMSO + CSE 3% control and were therefore filtered out of swell hit selection. …”
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    Hit validation of the findings in Fig 1. by Danny Wilbie (14050812)

    Published 2025
    “…Of these, alisertib, rucaparib and belinostat yielded a clear dose-dependent HDR increase. B: The result of the three significant and dose-dependent hits from A separated into the gene knock-out (NHEJ, top) and correction (HDR, bottom) outcomes. …”
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    Concentration of RebA and Steviol showed increased significantly, whereas stevioside showed significant decrease in all the transgenic lines. by Nazima Nasrullah (6874496)

    Published 2023
    “…<p>Concentration of RebA and Steviol showed increased significantly, whereas stevioside showed significant decrease in all the transgenic lines.…”
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