Sustained increase in the levels of pro-inflammatory cytokine and chemokine in the testis correlate with systemic inflammation. by Stefanos Giannakopoulos (15628394)

“…<p><b>(A)</b> Heatmap of a panel of COVID-19 specific cytokine and chemokines measured using LUMINEX assay in the tissue homogenates (lung, testis, and heart) and serum of K18-hACE2 mice at indicated time points post-infection (n, <i>≥</i>4 mice per group). Data were normalized to the control, log10 transformed, and expressed as relative abundance (red, increased; blue, decreased; and white represents unchanged compared to uninfected controls). …”

Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario by Karoliny Nune Santos (21752603)

“…To evaluate the NLRP3 inhibitors effects: glibenclamide (GB) and MCC950, on markers of inflammation, endothelial dysfunction, cell death, and oxidative stress in an <i>in vitro</i> model of PE. Plasma from pregnant women with PE and normotensive pregnant women (NT) was used to investigate its impact on NLRP3 inflammasome activation (NLRP3, TLR4, MyD88, and caspase-1) in endothelial cells (ECs), analyzed by Western Blotting; effects of pharmacological inhibition on the function of ECs was assessed by the evaluation of permeability (VE-cadherin) and markers of endothelial dysfunction by flow cytometry (Flt-1, VEGFR2, E-selectin, VCAM-1, and ICAM-1), as well as cytotoxicity measured by lactate dehydrogenase (LDH), oxidative stress (ROS, nitric oxide - NO and antioxidant capacity), autophagy, and pyroptosis (interleukin IL-1β and high-mobility group box one - HMGB1). …”

Supplementary Material for: Clinical and brain MRI characteristics of patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A 10-Year Retrospective Study by figshare admin karger (2628495)

“…Although 91% of patients with mRS >2 before treatment, statistically significant decreased mRS were observed after treatment (mRS: 3.50 ± 0.94 vs mRS: 1.91 ± 1.53, P < 0.001). …”

Data Sheet 6_Efficacy and safety of different medications compared for the treatment of postherpetic neuralgia: a network meta-analysis.pdf by Zhen Guo (68566)

“…The secondary outcomes showed a significant effect of hydromorphone in improving sleep quality (MD = −3.8, 95% CI: [−23.0, −15.0]) and decreasing pain questionnaire scores (MD = −13.0, 95% CI: [−28.0, 2.1]). …”

Data Sheet 3_Efficacy and safety of different medications compared for the treatment of postherpetic neuralgia: a network meta-analysis.pdf by Zhen Guo (68566)

“…The secondary outcomes showed a significant effect of hydromorphone in improving sleep quality (MD = −3.8, 95% CI: [−23.0, −15.0]) and decreasing pain questionnaire scores (MD = −13.0, 95% CI: [−28.0, 2.1]). …”

Data Sheet 2_Efficacy and safety of different medications compared for the treatment of postherpetic neuralgia: a network meta-analysis.pdf by Zhen Guo (68566)

“…The secondary outcomes showed a significant effect of hydromorphone in improving sleep quality (MD = −3.8, 95% CI: [−23.0, −15.0]) and decreasing pain questionnaire scores (MD = −13.0, 95% CI: [−28.0, 2.1]). …”

Data Sheet 4_Efficacy and safety of different medications compared for the treatment of postherpetic neuralgia: a network meta-analysis.pdf by Zhen Guo (68566)

“…The secondary outcomes showed a significant effect of hydromorphone in improving sleep quality (MD = −3.8, 95% CI: [−23.0, −15.0]) and decreasing pain questionnaire scores (MD = −13.0, 95% CI: [−28.0, 2.1]). …”

Data Sheet 5_Efficacy and safety of different medications compared for the treatment of postherpetic neuralgia: a network meta-analysis.pdf by Zhen Guo (68566)

“…The secondary outcomes showed a significant effect of hydromorphone in improving sleep quality (MD = −3.8, 95% CI: [−23.0, −15.0]) and decreasing pain questionnaire scores (MD = −13.0, 95% CI: [−28.0, 2.1]). …”

Data Sheet 2_Comparison with healthy controls: meta-analysis of changes in intestinal flora in Chinese patients with irritable bowel syndrome.zip by Hao Tu (16412994)

“…In IBS-D Patients, Enterobacter (SMD = 1.47; 95% CI=[0.75, 2.19]; P < 0.0001) and Enterococcus (SMD = 0.53; 95% CI=[0.06, 1.01]; P = 0.03) remained elevated, while Lactobacillus (SMD=-1.39; 95% CI=[-1.76,-1.02];P < 0.00001), Bifidobacterium (SMD=-1.66; 95% CI=[-2.15,-1.17];P < 0.00001), and Bacteroides (SMD=-0.72; 95% CI=[-1.05, -0.39]; CI=[-1.05,-0.39];P < 0.0001) decreased significantly. …”

Assessing the Causal Role of Walking Pace and Hand Grip Strength with Chronic Obstructive Pulmonary Disease Hospital: A Mendelian Randomization Study by Lu Wang (45927)

“…</p> <p>Our research shows a link between slower walking pace and higher COPD hospitalization risk, as well as decreased lung function (PEF, FEV1, FVC). We also found a significant correlation between weaker hand grip and reduced lung function, especially FVC. …”

feature parameters by CHIN-CHENG CHU (20718575)

“…Sample Entropy on the X-axis decreased from 0.095 ± 0.054 to 0.080 ± 0.048 (p = 0.025) and on the Y-axis from 0.106 ± 0.046 to 0.090 ± 0.043 (p = 0.025), whereas Approximate Entropy and Cross Entropy showed no significant change. …”

Supplementary Material for: Characterisation of an ischaemia-reperfusion model for the formation of a stage II pressure injury in diabetic mice by figshare admin karger (2628495)

“…Ischemia durations of 8 and 16 h resulted in more severe full-thickness skin defects, including exposed subcutaneous adipose tissue and inward contraction of wound margins. After ischaemia (I) for 4 h and reperfusion (R) for 24 h, the morphology of fibroblasts in the compressed skin area of db/db mice changed, and the expression of TGF-β1 decreased significantly compared with those in WT mice. …”

Raw data for hand and arm dysfunction following hemodialysis access placement by Kyoungrae Kim (10312460)

“…RESULTS: Six weeks post-surgery, patients exhibited significant functional decline in the access limb. Postoperative grip strength declined by approximately 15% (P=0.0015), finger pressure decreased by ~30 mmHg (P<0.0001), and the perceived HAD score increased significantly (P=0.0450) compared to the preoperative values. …”

Photomicrograph of the gastric mucosa colored with an anti-caspase-3 antibody. by Rehab F. Taher (20478600)

“…<p>The percentage of caspase-3 positive cells having strong brown coloring is reduced in the omeprazole group (c), while the control ethanol group (d) exhibited increased expression of caspase-3 and a higher percentage of positive cells with powerful brown cytoplasmic and/or nuclear coloring, (d) PM-EtOH (25 mg/kg) group showing decreased expression of caspase-3, along with the presence of moderately stained cells, (e) PM-EtOH (50 mg/kg) group showing decreased percentage of caspase-3 positive cells, (f) PM-EtOH (100 mg/kg) group showing weak caspase-3 expression, via a significant lowering in caspase-3-positively colored cells. …”

Supplementary Material for: Successful Management of Post-Thymectomy Pure Red Cell Aplasia with Rituximab: A Case Report by Abdulgayoom M. (17726475)

“…Abstract Background: Pure red cell aplasia (PRCA) is a rare cause of anemia characterized by decreased red blood cell production, often associated with thymomas. …”

Effects of extracorporeal shock wave therapy on motor function in patients with cerebral palsy: a systematic review and meta-analysis by Hui-Hui Peng (21503736)

“…Comparison between the ESWT and control groups revealed significant improvements in MAS (standardized mean difference [SMD]: −0.84, 95% confidence intervals [CIs]: −1.23 to −0.46, <i>p</i> < 0.001), gait speed (MD: 0.12, 95% CI: 0.02–0.23, <i>p</i> = 0.02), cadence (MD: −3.01, 95% CI: −6.03 to 0, <i>p</i> = 0.05), stride length (MD: 0.22, 95% CI: 0.16–0.28, <i>p</i> < 0.001), Pediatric Balance Scale (MD: 2.3, 95% CI: 0.4–4.19, <i>p</i> = 0.02), and Gross Motor Function Measure-88 (MD: 9.72, 95% CI: 7.36–12.08, <i>p</i> < 0.001).…”

Table 6_Integrative bioinformatics analysis of pyroptosis-related genes and immune infiltration patterns in childhood asthma.xlsx by Di Lian (11639675)

“…</p>Results<p>Immune cell infiltration analysis using the CIBERSORT algorithm revealed significant differences between the CA and control groups, with increased macrophages M0, activated mast cells, and γδ T cells and decreased resting natural killer cells in the CA group. …”

Table 5_Integrative bioinformatics analysis of pyroptosis-related genes and immune infiltration patterns in childhood asthma.xlsx by Di Lian (11639675)

“…</p>Results<p>Immune cell infiltration analysis using the CIBERSORT algorithm revealed significant differences between the CA and control groups, with increased macrophages M0, activated mast cells, and γδ T cells and decreased resting natural killer cells in the CA group. …”

Table 3_Integrative bioinformatics analysis of pyroptosis-related genes and immune infiltration patterns in childhood asthma.xlsx by Di Lian (11639675)

“…</p>Results<p>Immune cell infiltration analysis using the CIBERSORT algorithm revealed significant differences between the CA and control groups, with increased macrophages M0, activated mast cells, and γδ T cells and decreased resting natural killer cells in the CA group. …”

Table 4_Integrative bioinformatics analysis of pyroptosis-related genes and immune infiltration patterns in childhood asthma.xlsx by Di Lian (11639675)

“…</p>Results<p>Immune cell infiltration analysis using the CIBERSORT algorithm revealed significant differences between the CA and control groups, with increased macrophages M0, activated mast cells, and γδ T cells and decreased resting natural killer cells in the CA group. …”