Image 1_Metformin enhances alpelisib sensitivity in HER2+ breast cancer by suppressing cancer stemness and oncogenic signaling.tif حسب Yujie Shi (737203)

"…Combination treatment induced significant G0/G1 cell-cycle arrest, reduced ALDH1⁺ populations, and decreased tumorsphere formation. …"

Table 4_Apoptosis and autophagy promote Babesia microti infection in tick midguts: insights from transcriptomic and functional RNAi studies.xls حسب Songqin Chen (9625886)

"…Functional assays demonstrated that RNA interference (RNAi)-mediated knockdown of caspase-7, caspase-9, and ATG5 significantly reduced the burden of B. microti. Conversely, pharmacological induction of autophagy using rapamycin increased B. microti load, whereas inhibition with 3-methyladenine (3-MA) decreased B. microti load.…"

Image 2_Interleukin-26 expression in tuberculosis disease and its regulatory effect in macrophage polarization and intracellular elimination of Mycobacterium tuberculosis.jpeg حسب Kaisong Huang (5412626)

"…In this study, we observed significantly elevated IL-26 mRNA expression in peripheral blood mononuclear cells of active-TB patients compared to healthy individuals. …"

DataSheet2_Dysregulation of the 3β-hydroxysteroid dehydrogenase type 2 enzyme and steroid hormone biosynthesis in chronic kidney disease.xlsx حسب Yiyi Zuo (19945293)

"…</p>Results<p>Metabolic characteristics revealed significant shifts in CKD, with 61 metabolites increased and 65 metabolites decreased, highlighting the disruption in steroid hormone biosynthesis pathways influenced by HSD3B2. …"

The atrium and ventricle exhibit different tissue dynamics during morphogenesis. حسب Juliana Sánchez-Posada (20636677)

"…Total endocardial volume decreases after 58 hpf (D), driven by a reduction in endocardial tissue in both the atrium and ventricle (E); 34–36 hpf: <i>n</i> = 9; 48–50 hpf: <i>n</i> = 10; 58–60 hpf: <i>n</i> = 8; 72–74 hpf: <i>n</i> = 10. …"

Image 1_Application and validation of the machine learning-based multimodal radiomics model for preoperative prediction of lateral lymph node metastasis in papillary thyroid carcin... حسب Jia-Wei Feng (10754067)

"…Current diagnostic methods show significant limitations, with occult LLNM rates of 41.0%-51.7% requiring secondary surgeries. …"

Data Sheet 1_Visual attention during non-immersive virtual reality balance training in older adults with mild to moderate cognitive impairment: an eye-tracking study.pdf حسب Marcos Maldonado-Díaz (11221102)

"…Clinical tests revealed a slight increase, though results were not statistically significant in balance and walking speed (p = 0.063). …"

Table_4_Functional Characterization of Olfactory Proteins Involved in Chemoreception of Galeruca daurica.docx حسب Ling Li (38566)

"…The EAG response of G. daurica females to 2-hexenal was significantly decreased in dsRNA-OBP15-injected treatment compared to the control, and the dsRNA-CSP5-treated females significantly reduced EAG response to eight tested host volatiles (1,3-dithiane, 2-hexenal, methyl benzoate, dimethyl trisulfide, myrcene, hexanal, 1,3,5-cycloheptatriene, and p-xylene). …"

Video 2_Muscle-specific Bet1L knockdown induces neuromuscular denervation, motor neuron degeneration, and motor dysfunction in a rat model of familial ALS.mp4 حسب Adam Eckardt (20573576)

"…Bet1L knockdown decreased motor neuron size in the lumbar spinal cord, which innervated the siRNA-injected hindlimb. …"

Table 2_High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways.docx حسب Jian-Tong (21583487)

"…Correlational analysis revealed significant associations between these pathways and inflammatory/oxidative markers. …"

Image1_Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study.tif حسب Chao Bai (4428472)

"…Objective<p>Diabetic neuropathy (DN), a common and debilitating complication of diabetes, significantly impairs the quality of life of affected individuals. …"

Table 1_Cholesterol metabolic reprogramming drives the onset of DLBCL and represents a promising therapeutic target.docx حسب Lili Zhou (265076)

"…</p>Results<p>We confirmed significant alterations in metabolic markers (such as TC and ApoA1) between the healthy control group and patients, which were significantly associated with patient prognosis and overall OS. …"

Data Sheet 1_Radiomics reveals the biological basis for non-small cell lung cancer prognostic stratification by reflecting tumor immune microenvironment heterogeneity.docx حسب Qing Huang (240196)

"…Immune microenvironment profiling showed significantly reduced immune scores and decreased proportions of naive B cells in high-risk patients, indicating impaired immune activity. …"

Analysis diagram of Ecological carrying system. حسب Hui Li (32376)

"…Our results indicate significant changes in land types within the TGRR from 1986 to 2020, with decreases in arable land, forest land, and grassland, while water bodies, building land, and unused land increased. …"

Table 1_Altered brain functional network connectivity and topology in type 2 diabetes mellitus.doc حسب Weiwei Ni (9269921)

"…</p>Discussion<p>This study demonstrated significant abnormalities in connectivity and topology of large-scale brain functional networks in T2DM patients. …"

Image 2_Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling.jpeg حسب Yiwen Li (354034)

"…</p>Results<p>GXN treatment significantly reduced myocardial injury in diabetic mice and decreased oral F. nucleatum abundance, although its effects on other gut microbiota taxa were variable. …"

Model inputs. حسب Natalia Serpetti (5260715)

"…The spatial/temporal model successfully simulated the overall ongoing declining dynamics of the Black Sea ecosystem as the biomasses of the majority of the functional groups had significant observed decreasing trends during the simulation period. …"

<b>Precursor and Mature miRNA Sequences from the Hepatopancreas of Macrobrachium rosenbergii under Low-Temperature Stress</b> حسب jinlin gong (21467675)

"…Prior heritability analyses indicated no significant difference in cold tolerance among the 27 families used.…"

Table 1_Trends in the burden of chronic diseases attributable to diet-related risk factors from 1990 to 2021 and the global projections through 2030: a population-based study.docx حسب Huan Ma (713125)

"…In low-SDI regions, diets low in vegetables showed the strongest association with neoplasm-related mortality, while diets low in fruits were significantly linked to CVD and diabetes burden. High-sodium diet was a significant risk factor for CVD in the middle-SDI regions. …"

Video 1_Muscle-specific Bet1L knockdown induces neuromuscular denervation, motor neuron degeneration, and motor dysfunction in a rat model of familial ALS.mp4 حسب Adam Eckardt (20573576)

"…Bet1L knockdown decreased motor neuron size in the lumbar spinal cord, which innervated the siRNA-injected hindlimb. …"