Table 1_The efficacy and safety of danuglipron and orforglipron in patients with type 2 diabetes and obesity: a systematic review and meta-analysis.docx by Jingjing Zhou (179820)

“…Meta-analysis results demonstrated that danuglipron significantly decreased HbA1c (mean difference [MD]: −0.90; 95% CI: −1.06, −0.74), FPG (MD: −24.66; 95% CI: −30.45, −18.86) and weight (MD: −2.17; 95% CI: −3.10, −1.23) and improved FPI (MD: 2.94; 95% CI: 1.50, 4.38). …”

Data Sheet 1_Global burden of cancer in adolescents and young adults aged 10–24 years: a trend analysis.pdf by Junjun Yang (307892)

Prognostic value of cardiac troponin I in acute ischemic stroke patients treated with reperfusion therapy: a multicenter retrospective cohort study by Andrea Loggini (12077927)

“…Elevated cTnI was not significantly associated with sICH (OR:3.75, 95%CI 0.52–27.21, <i>p</i> = 0.19), but was independently associated with increased in-hospital mortality (OR:1.96, 95%CI 1.62–6.20, <i>p</i> = 0.025) and decreased odds of good functional outcome at 30 days (OR:0.40, 95%CI 0.19–0.84, <i>p</i> = 0.016). …”

<b><i>Escherichia coli α-hemolysin induces red blood cell retention in a microfluidic spleen-like device</i></b> by Nicolas Saffioti (9965939)

“…</p><p dir="ltr">Our results suggest that the increase in cytosolic Ca²⁺ elicited by HlyA impacts RBCs’ circulation by decreasing RBCs’ deformability and increasing spleen retention. …”

Table 1_Obstetric and perinatal outcomes in pregnancies conceived with donor versus partner sperm: a systematic review and meta-analysis.docx by Junjie Liu (193511)

“…Background<p>Male-related factors contribute to 30-40% of infertility cases, with donor sperm serving as a critical solution for severe male infertility or paternally inherited genetic disorders. …”

Inference of cell-type proportions from bulk RNAseq and dynamics during myocardial infarction in α1A-AR-KO mice. by Brian Gural (21781982)

“…<b>(D)</b> Estimation of cardiac cell type composition changes post-myocardial infarction (MI) and in α1A-AR knockout (cmAKO) mice, showing increased proportions of macrophages and fibroblasts and decreased proportions of cardiomyocytes, with more pronounced changes in cmAKO mice. …”

DataSheet1_Efficacy and safety of danshen class injections in the treatment of coronary heart disease: a network meta-analysis.docx by Shuang Dai (1413496)

“…The results of NMA showed that, XD injection significantly enhances clinical efficacy; STS is more effective in reducing hs-CRP levels; DSDFSY shows better efficacy in decreasing IL-1 and increasing NO levels; DSCXQ has a greater advantage in reducing IL-6 levels; GXN is more effective in regulating SOD levels; and DH is better at reducing MDA levels.…”

<i>Piriformospora indica</i> Mediated Amelioration of Salt Stress in <i>Solanum melongena</i> L. Plants under Greenhouse- A Study on Stomatal Opening/Closure by Swetha Seshagiri (20586100)

“…<p>Salinity is a major abiotic stress that negatively affects agricultural land, significantly reducing crop yields. …”

Data Sheet 1_Hypocomplementemia dynamics during tocilizumab therapy in systemic juvenile idiopathic arthritis: a retrospective longitudinal study.xlsx by Jiayun Ling (15249289)

“…After 2 weeks of TCZ treatment, median (IQR) serum C3 levels declined from 1.45(1.27-1.75) g/L at baseline to 1.11 (0.97-1.18) g/L (a 23.45% reduction, P = 0.009), and C4 levels decreased from 0.29 (0.21-0.38) g/L to 0.13 (0.09-0.17) g/L (a 55.17% reduction, P = 0.005). …”

Data Sheet 1_Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway.docx by Yumei Rong (11589031)

“…</p>Methods<p>Photodynamic therapy (PDT) with a novel photosensitizer LD₄ was used to treat UC rat models to explore the therapeutic effect and mechanism of LD₄-PDT on UC. 16S ribosomal RNA was used to detect the composition of Gut microbiota.…”

Table 1_Effect of compound kushen injection on immune function in patients with colorectal cancer: a systematic review and meta-analysis.docx by Lixin Zhang (55947)

“…Compared to conventional chemotherapy (CC), the combination of CKI with CC significantly enhanced immune function, increasing CD3⁺ levels (MD = 6.15, 95% CI: 4.78 to 7.53, p < 0.00001), CD4⁺ levels (MD = 8.05, 95% CI: 6.99 to 9.11, p < 0.00001), CD4+/CD8+ levels (MD = 0.36, 95% CI: 0.28 to 0.44, p < 0.00001), NK cell levels (MD = 3.60, 95% CI: 2.85 to 4.34, p < 0.00001), while reducing CD8⁺ levels (MD = −4.19, 95% CI: −5.11 to −3.27, p < 0.00001). …”

Table 1_Targeting APE1/Ref-1 to alleviate formalin-induced pain and spinal neuro-inflammation in rats: a promising therapeutic approach.xlsx by Eman Elgendy (21811052)

“…Notably, E3330 treatment maintained normal APE1/Ref-1 levels and promoted a more organized mitochondrial structure. Administration of E3330 correlated with increased dopamine levels, a decrease in the mRNA expression of dopamine receptors DRD1 and DRD5, and a restoration of DRD2 expression in the ipsilateral spinal cords. …”

DataSheet1_Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China.docx by Chuican Huang (15107903)

“…Regional differences were noted, with the highest deficiency in semiarid and subhumid zones for various age groups.</p>Conclusion<p>A significant increase in VDD with age, particularly among adolescents, urban girls, and during autumn, emphasizing the need for targeted strategies.…”

Data Sheet 2_Assessing the evolution of infectious disease preparedness among a province with poor economy in China in the wake of COVID-19.docx by Huaying Liu (8312517)

“…</p>Results<p>Post-COVID-19, there was a significant increase in the scores for theoretical knowledge (77.10 ± 14.83 vs. 63.10 ± 15.11, p < 0.001) and understanding of infectious disease regulations (54.78 ± 15.94 vs. 50.85 ± 12.52, p = 0.001) among grassroots hospital physicians compared to pre-COVID-19 levels, albeit with room for further improvement. …”

Data Sheet 1_Assessing the evolution of infectious disease preparedness among a province with poor economy in China in the wake of COVID-19.docx by Huaying Liu (8312517)

“…</p>Results<p>Post-COVID-19, there was a significant increase in the scores for theoretical knowledge (77.10 ± 14.83 vs. 63.10 ± 15.11, p < 0.001) and understanding of infectious disease regulations (54.78 ± 15.94 vs. 50.85 ± 12.52, p = 0.001) among grassroots hospital physicians compared to pre-COVID-19 levels, albeit with room for further improvement. …”

Table 1_Impact of in-hospital COVID-19 quarantine policy changes on quality of acute stroke care: a single center experience.docx by Minkyung Kim (741928)

“…When pre-and post-COVID-19 screening epochs were compared, DIT, door-to-neurologist referral time, and DPT showed numerical increases. However, after accounting for potential confounders, a significant delay in DIT was found to be associated with the in-hospital COVID-19 quarantine policy.…”

Assessing the Causal Role of Walking Pace and Hand Grip Strength with Chronic Obstructive Pulmonary Disease Hospital: A Mendelian Randomization Study by Lu Wang (45927)

“…</p> <p>Our research shows a link between slower walking pace and higher COPD hospitalization risk, as well as decreased lung function (PEF, FEV1, FVC). …”

Supplementary file 1_Global burden of childhood otitis media attributable to secondhand smoke from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.pd... by Bei Li (90587)

“…Background<p>Childhood otitis media is significantly influenced by exposure to secondhand smoke (SHS), posing a considerable challenge to pediatric health. …”

Data Sheet 1_Therapeutic effects of traditional Chinese medicine Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota.docx by Xiaoxia He (459582)

“…<p>Hua-Feng-Dan is a traditional Chinese medicine used to treat ischemic stroke, but little is known about its therapeutic mechanism. …”

Table 4_Association between cardiovascular health and markers of liver function: a cross-sectional study from NHANES 2005–2018.docx by Huang Yu (5882174)

“…Weighted quantile sum (WQS) regression and quantile g-computation (QGC) analyses were employed to evaluate the association between CVH and liver function markers.</p>Results<p>Linear regression analysis showed that each 1-point increase in CVH score was significantly associated with decreased levels of liver enzymes [ALT: −0.200 U/L (95% CI: −0.223, −0.176), AST: −0.043 U/L (−0.062, −0.024), GGT: −0.453 U/L (−0.509, −0.397), ALP: −0.310 U/L (−0.340, −0.281)] and increased levels of albumin [0.040 g/dL (0.036, 0.045)] and AST/ALT ratio [0.0056 (0.0051, 0.0061)]. …”