Spectral shift of fluorophore NHS-esters. حسب Hyunwoo Kim (690467)

"…After 5 min of illumination with a 561-nm excitation laser, the fluorescence signal in the 647-nm detection channel decreased, while the signal in the 561-nm detection channel significantly increased, indicating a spectral blue-shift of the emission spectrum. …"

Data Sheet 1_A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure.docx حسب Ambrish Kumar (558337)

"…TAC-induced pressure-overload decreased ejection fraction and increased cardiac hypertrophy and dilation, fibrosis, apoptosis, oxidative stress, and macrophage infiltration in the left ventricles. …"

Data Sheet 1_Fast perceptual learning induces location-specific facilitation and suppression at early stages of visual cortical processing.docx حسب Yajie Wang (184298)

"…ERP results showed that tens of minutes of training not only increased the late P1c-i (~100–120 ms) evoked by targets at the trained location, but also decreased the early P1c-i (~75–95 ms) evoked by distractors at the untrained location, both of which were location specific. …"

<b>The Bacterial OMP Amyloids Modulate</b><b> </b><b>α</b><b>-Synuclein and Amyloid-</b><b>β</b><b> </b><b>Aggregation</b> حسب Maksim Sulatsky (21562922)

"…In contrast, amyloid-β fibrils showed more extensive structural changes, with modifications to both the "fuzzy coat" and β-sheet core, accompanied by decreased clustering tendency and significantly reduced toxicity for mammalian neuroblastoma and epithelial adenocarcinoma cell lines. …"

<b>Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional </b><b><i>WFS1</i></b><b> varian... حسب Silvia Torchio (611349)

"…Pancreatic β cells obtained from patient-derived induced Pluripotent Stem Cells (iPSCs) carrying this <i>WFS1 </i>variant exhibited reduced insulin processing and impaired secretory granule maturation, as evidenced by proinsulin accumulation and decreased prohormone convertase PC1/3. Moreover, they exhibited dysregulated Ca²⁺ fluxes due to altered transcription of Ca²⁺-related genes, including <i>CACNA1D</i>, and significantly reduced <i>SNAP25</i> levels, leading to uncoordinated oscillations and poor glucose responsiveness. …"

Data Sheet 1_Preoperative remote consultation for a green bariatric surgery: can telemedicine be safe for patients and sustainable for the environment?.pdf حسب Luigi Eduardo Conte (21669149)

"…Background<p>The increasing emphasis on sustainability and digitalization has brought telemedicine to the forefront, particularly in bariatric surgery. …"

Image 1_Elevated miR-17-5p facilitates mycobacterial immune evasion by targeting MAP3K2 in macrophages.jpeg حسب Md Shoykot Jahan (22776341)

"…Increased miR-17-5p suppressed MAP3K2 expression and attenuated MAPK signaling, reducing phosphorylation of ERK, JNK, and p38. …"

Data Sheet 1_Efficacy and safety of anlotinib combined with 125I seed implantation for iodine-refractory thyroid cancer.docx حسب Zhijun Chen (254277)

"…Tumor volumes in all groups decreased after treatment, with the greatest reduction within 6 months in the combination group (p < 0.001). …"

Image3_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.TIF حسب Wen Zhou (49050)

"…It also alleviated inflammatory responses, including microglial activation and leukocyte infiltration, relieved the impairment of the brain blood barrier and edema, and reduced neuronal apoptosis, axonal loss, and demyelination induced by EAE. The C16 peptide increased the expressions of pTie-2 and Tie-2, integrin αvβ3, and α5β1 and activated the PI3K/Akt signal pathway but decreased the expression of Rho. …"

Image7_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG حسب Wen Zhou (49050)

"…It also alleviated inflammatory responses, including microglial activation and leukocyte infiltration, relieved the impairment of the brain blood barrier and edema, and reduced neuronal apoptosis, axonal loss, and demyelination induced by EAE. The C16 peptide increased the expressions of pTie-2 and Tie-2, integrin αvβ3, and α5β1 and activated the PI3K/Akt signal pathway but decreased the expression of Rho. …"

Image9_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG حسب Wen Zhou (49050)

"…It also alleviated inflammatory responses, including microglial activation and leukocyte infiltration, relieved the impairment of the brain blood barrier and edema, and reduced neuronal apoptosis, axonal loss, and demyelination induced by EAE. The C16 peptide increased the expressions of pTie-2 and Tie-2, integrin αvβ3, and α5β1 and activated the PI3K/Akt signal pathway but decreased the expression of Rho. …"

Data Sheet 1_miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.pdf حسب Juanjuan Zhang (432819)

"…</p>Results<p>Histopathological analysis showed that miR-223 agomir significantly attenuated DSS-induced colon damage. Proinflammatory cytokines (TNF-α, IL-1β, IL-6) increased in DSS mice, while anti-inflammatory IL-10 decreased—trends reversed by miR-223 supplementation at mRNA/protein levels. …"

Table1_SMAD4 enhances the cytotoxic efficacy of human NK cells against colorectal cancer cells via the m6A reader YTHDF2.docx حسب Xinxin Li (281237)

"…</p>Results<p>Our findings revealed that the expression of SMAD4 is decreased in NK cells within the TME of human CRC. …"

Image 3_Natural killer cell as a potential predictive biomarker for early immune checkpoint inhibitor-associated cardiovascular adverse events: a retrospective cohort study.tif حسب Yujuan Wu (2249857)

"…</p>Results<p>ScRNA-seq data revealed decreased CD8+ T and B cell proportions in the CVAEs group, while NK cell proportions increased. …"

Data Sheet 1_An active ingredient from the combination of Corydalis Rhizoma and Paeoniae Radix Alba relieves chronic compression injury-induced pain in rats by ameliorating AR/Mboa... حسب Ze-Ming Wang (9572399)

"…</p>Results<p>The results demonstrated that YB60 significantly decreased inflammatory cytokine levels both in cellular models and rat serum, while concurrently elevating pain thresholds in CCI rats. …"

Data Sheet 1_Effects of aging and valence on emotional response inhibition: conclusions from a novel stop-signal task.pdf حسب Jill D. Waring (6652103)

"…Aging is associated with decreasing cognitive control and inhibition alongside improvements in emotional control and regulation. …"

Data Sheet 1_Renewable energy consumption optimization allocation strategy for a regional microgrid based on a shared energy storage mechanism.zip حسب Hongde Ma (20137539)

"…The research results show that after configuring shared energy storage, the operating cost of the regional microgrid system decreases by 15.12%, the new energy consumption rate increases to 97.44%, and the shared energy storage service provider can recover the investment cost within 4.62 years. …"

Mass spectrometry of Pparα-En4 pulldown proteins. حسب Tingting Jiang (169999)

"…Functional assays demonstrated that targeted repression of Pparα-En4 region significantly decreased <i><i>Ppar</i>α</i> expression and impaired brown adipocyte differentiation and thermogenesis. …"

Knockdown of fatty acid binding protein 3 attenuates cerebral Ischemia-reperfusion injury <i>via</i> inhibiting neuronal apoptosis in mice حسب Jin-Jin Tian (22046330)

"…Moreover, FABP3 knockdown decreased the expression of pro-apoptotic proteins (Bax, cleaved-caspase-3) while increasing anti-apoptotic Bcl-2 levels. …"

Table 2_IFN-treated macrophage-derived exosomes prevents HBV-HCC migration and invasion via regulating miR-106b-3p/PCGF3/PI3K/AKT signaling axis.docx حسب Jing Chen (4762)

"…Significantly increased expression of miR-106b-3p and decreased expression of HBsAg and HBV DNA were observed in Huh7-C2/B3 cells treated with IFN-exo. …"