Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario حسب Karoliny Nune Santos (21752603)

"…Both GB and MCC950 reduced NLRP3 inflammasome activation and its related effects in ECs exposed to PE plasma, including lowered IL-1β, caspase-1, modulated adhesion molecules expression, as well as decreased ROS and cytotoxicity. GB increased NO and restored VE-cadherin expression, while MCC950 enhanced antioxidant capacity. …"

Data Sheet 1_Efficacy and mechanism of cyprosulfamide in alleviating the phytotoxicity of clomazone residue on maize seedling.docx حسب Lanlan Sun (1798921)

"…Additionally, the combination of CSA and Clo reduced MDA levels by 13.4%, increased SOD activity by 9.7% and GST activity by 26.7%, while elevating GSSG content by 31.3% compared to Clo alone, ultimately mitigating oxidative damage in maize plants. qRT-PCR analysis showed that the expression of five P450 genes (CYP72A5, CYP81A4, CYP81Q32, CYP81A9, CYP81A36), nine GST genes (GST30, GST31, GSTIV, GSTVI, GST21, GST7, GST37, GST25, IN2-1), and two UGT genes (UGT76C2, UGT83A1) significantly high increased by 6.74-, 10.27-, 4.98-, 10.56-, 25.67-, 16.70-, 46.92-,7.53-, 5.10-, 238.82-, 143.50-, 4.58-, 31.51-, 39.3-, 4.20-, 10.47-fold after CSA+Clo treatment compared to that in the Clo treatment. …"

Inference of cell-type proportions from bulk RNAseq and dynamics during myocardial infarction in α1A-AR-KO mice. حسب Brian Gural (21781982)

"…<b>(D)</b> Estimation of cardiac cell type composition changes post-myocardial infarction (MI) and in α1A-AR knockout (cmAKO) mice, showing increased proportions of macrophages and fibroblasts and decreased proportions of cardiomyocytes, with more pronounced changes in cmAKO mice. …"

Data Sheet 1_Global burden of disease among adolescents and young adults with drug use disorders, 1990–2021: based on GBD 2021.doc حسب Ming Wang (172316)

"…Additionally, gender plays a significant role in the distribution of this burden, with males experiencing a higher burden than females. …"

Image 4_Global burden of varicella and herpes zoster across 204 countries, 1990–2021: a temporal trend analysis in the era of the COVID-19 pandemic and projections to 2036.tiff حسب Zilun Wu (18696883)

"…Mortality and DALYs declined significantly, with age-standardized mortality rates (ASMR) and DALYs rates (ASDR) decreasing by 50.0 and 36.3%, respectively. …"

Supplementary file 1_Proof-of-concept of a prior validated LC-MS/MS method for detection of N-lactoyl-phenylalanine in dried blood spots before, during and after a performance diag... حسب H. Bauhaus (22335913)

"…</p>Results<p>Lac-phe concentrations increased from 31.5 ± 10 nmol/L at baseline to a maximum of 101.0 ± 40.1 nmol/L at time-to-exhaustion after the second incremental test. 15 min after exercise, lac-phe concentration decreased to 89.7 ± 30.4 nmol/L. …"

Table 4_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.xlsx حسب Fuxing Lin (7418234)

"…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …"

Image 2_A unique polygenic mouse model of obesity exhibits a distinct immunological profile that may offer protection against systemic inflammation, diabetes, and behavioral impair... حسب Ulrike Gimsa (9730208)

"…Following psychological stress induced by the elevated plus-maze test, the number of CD4+ T cells increased and the number of macrophages decreased in both mouse lines. …"

Table 1_Long-term multicomponent exercise enhances functional mobility in early-stage Parkinson’s disease: a 48-month retrospective cohort study.docx حسب Marcos Moura (22671914)

"…</p>Results<p>After 48 months, TUG time decreased by −3.8 s (95% CI: −5.0 to −2.6; p < 0.001; dz = −1.12) and 6MWT distance increased by +88.8 m (95% CI: 45.1 to 133.0; p < 0.001; dz = 0.72), both exceeding MDC thresholds. …"

Figure 3 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRP... حسب Makito Mizunuma (18950775)

"…The right shifts of the peaks in the MDA-MB468, BT549, and Hs578T sensitive cell lines indicate increased permeability. <b>B,</b> Flow cytometric mitochondrial membrane potential (MT-1) assay. …"

Supplementary file 1_Exploration of the renoprotective effect of Yi-Shen-Hua-Shi granules on db/db mice and the mechanism of podocyte apoptosis based on the GRP78/CHOP signaling pa... حسب Yanmo Cai (22235563)

"…Pathological staining showed reduced renal tissue damage in mice, and electron microscopy revealed reduced pedunculopontine fusion and basement membrane thickening. YSHS decreased GRP78, PERK, p-PERK, CHOP, and Bax proteins and mRNA levels in renal tissues and MPC-5 cells (p < 0.05 and p < 0.01) while increasing the expression level of Nephrin protein and Bcl-2 mRNA (p < 0.05 and p < 0.01).…"

Data Sheet 1_EURAD state-of-the-art report: thermo-hydro-mechanical behaviour of clay buffers at high temperatures.pdf حسب María Victoria Villar (20955281)

"…The clay mineralogy was significantly preserved. The slight changes observed in the other properties were opposite depending on the heating conditions: in the case of evaporation, the cation exchange capacity, specific surface area, sorption coefficients, and sometimes swelling pressure decreased. …"

DataSheet1_Shenshuaikang enema restores the intestinal barrier and microbiota-gut-kidney axis balance to alleviate chronic kidney disease via NF-κB pathway.docx حسب Yan Ye (549400)

"…Introduction<p>Chronic kidney disease (CKD) is a chronic progressive disease characterized by abnormalities in kidney structure or function caused by variousfactors. It has become a significant public health problem, posing a threat to human health worldwide. …"

Table 1_Effect of ticagrelor combined with metoprolol extended-release tablets on cardiac function and clinical prognosis in elderly patients with acute coronary syndrome after per... حسب Lili Wang (104605)

"…</p>Results<p>The treatment effectiveness rate in the OG was 97.78%, significantly higher than the CG's rate of 77.78% (P < 0.05). …"

Table 1_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.docx حسب Fuxing Lin (7418234)

"…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …"

Table 2_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf حسب Ying Xiao (6517)

"…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …"

Data Sheet 1_From court to community: a cost–benefit evaluation of a community sports programme for Arab women in Israel's multiethnic context.docx حسب Limor Dina Gonen (14258380)

"…Gains in mental well-being were observed but did not reach statistical significance (p = 0.09). Modest increases were found in social capital and community engagement. …"

Data Sheet 1_CARTOON-based educational intervention for children to foster hygiene knowledge and emotional resilience in preschool children: a randomized controlled trial.pdf حسب Philipp Steinbauer (10792029)

"…Additionally, anxiety scores significantly decreased in the intervention group post-intervention compared to baseline (2.2 ± 1.7 vs. 5.6 ± 2.5; p = .01). …"

Table 2_A unique polygenic mouse model of obesity exhibits a distinct immunological profile that may offer protection against systemic inflammation, diabetes, and behavioral impair... حسب Ulrike Gimsa (9730208)

"…Following psychological stress induced by the elevated plus-maze test, the number of CD4+ T cells increased and the number of macrophages decreased in both mouse lines. …"

Image 2_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.tif حسب Fuxing Lin (7418234)

"…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …"