Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

PRISMA flow diagram of study selection. by Masoud Rahmati (16665456)

“…Meta-regression analysis indicated that for every one-year increase in age, ADL performance decreased by an average of 0.0147 units (p < 0.001), while IADL performance declined at a slower rate of 0.0047 units/year (p = 0.031).…”

General characteristics of included studies. by Masoud Rahmati (16665456)

“…Meta-regression analysis indicated that for every one-year increase in age, ADL performance decreased by an average of 0.0147 units (p < 0.001), while IADL performance declined at a slower rate of 0.0047 units/year (p = 0.031).…”

Characteristics of individual studies. by Masoud Rahmati (16665456)

“…Meta-regression analysis indicated that for every one-year increase in age, ADL performance decreased by an average of 0.0147 units (p < 0.001), while IADL performance declined at a slower rate of 0.0047 units/year (p = 0.031).…”

The Influence of Nucleating Agent Positional Isomer Structure on the Nucleation Efficiency of Poly(lactic acid): Interaction-Induced Conformational Transitions under High Lattice M... by Jingbo Wu (328587)

“…The results demonstrate that 2ODPTA (with hydroxyl groups at the ortho position) exhibits the highest nucleating activity. At a loading level of 0.5 wt %, 2ODPTA significantly increases the crystallization peak temperature to 121.5 °C, whereas as the hydroxyl substitution shifts from the ortho position to the para position, the temperature decreases to 108.2 and 105.8 °C, respectively. …”

The Influence of Nucleating Agent Positional Isomer Structure on the Nucleation Efficiency of Poly(lactic acid): Interaction-Induced Conformational Transitions under High Lattice M... by Jingbo Wu (328587)

“…The results demonstrate that 2ODPTA (with hydroxyl groups at the ortho position) exhibits the highest nucleating activity. At a loading level of 0.5 wt %, 2ODPTA significantly increases the crystallization peak temperature to 121.5 °C, whereas as the hydroxyl substitution shifts from the ortho position to the para position, the temperature decreases to 108.2 and 105.8 °C, respectively. …”

Baseline characteristics. by Seung Min Lee (1644409)

“…The distance of the FD decreased (<i>P</i> < 0.001) and FVs increased (<i>P</i> < 0.001, both). …”

Data file used in this study. by Seung Min Lee (1644409)

“…The distance of the FD decreased (<i>P</i> < 0.001) and FVs increased (<i>P</i> < 0.001, both). …”

Changes in foveal location after surgery. by Seung Min Lee (1644409)

“…The distance of the FD decreased (<i>P</i> < 0.001) and FVs increased (<i>P</i> < 0.001, both). …”

Histogram of the area factorψ. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Raw dataset Fig. 6. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Schematic for measuring <i>D</i> and <i>D</i>′ values. by Hong Zhang (25820)

“…The measured <i>I</i>_s decreases following a power-law trend as <i>β</i> and <i>D</i> increase, with weathering reducing the sensitivity of <i>I</i>_s to <i>β</i> but not significantly altering its sensitivity to <i>D</i>. …”

Primer sequences for RT-qPCR. by Wenlong Shen (9313937)

“…Western blot (WB) analysis showed that NCOA4 downregulation led to an increase in GPX4 expression. The cell cloning assay confirmed that downregulation of NCOA4 significantly increased cell viability. …”

siRNA sequences and negative controls sequences. by Wenlong Shen (9313937)

“…Western blot (WB) analysis showed that NCOA4 downregulation led to an increase in GPX4 expression. The cell cloning assay confirmed that downregulation of NCOA4 significantly increased cell viability. …”

Antibodies used in the study. by Wenlong Shen (9313937)

“…Western blot (WB) analysis showed that NCOA4 downregulation led to an increase in GPX4 expression. The cell cloning assay confirmed that downregulation of NCOA4 significantly increased cell viability. …”

Design of a RSSCA system for agriculture. by Ngoc-Hai Vu (22290844)

“…<div><p>Agricultural land is increasingly under pressure from expanding solar energy infrastructure, leading to a growing conflict between food and energy production. …”

List of drug resistance gene. by Shuai Huang (60512)

“…Additionally, 16S rRNA species profiling revealed that the composting process significantly altered the microbial community structure, with an increased abundance of Firmicutes and a decreased abundance of Bacteroidetes in composted pig manure. …”