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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Addressing Challenges of Distance Learning in the Pandemic with Edge Intelligence Enabled Multicast and Caching Solution
Published 2022“…While exploring the opportunities of EI-enabled distance learning, we demonstrate a significant reduction in network operator resource utilization and an increase in user QoE for VNF based multicast transmission.…”
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Mixed precision iterative refinement with adaptive precision sparse approximate inverse preconditioning
Published 2025“…Our numerical experiments show that this approach can potentially lead to a reduction in the cost of storing and applying sparse approximate inverse preconditioners, although a significant reduction in cost may comes at the expense of increasing the number of GMRES iterations required for convergence.…”
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Reinforced steering Evolutionary Markov Chain for high-dimensional feature selection
Published 2024“…(v) The effective size of successful agents is reduced recursively while progressing through different states to further facilitate the speed of convergence and decrease the number of features. (vi) The performance comparison with state-of-the-art feature selection methods shows a significant improvement and promise of the proposed method over the existing methods.…”
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Towards secure private and trustworthy human-centric embedded machine learning: An emotion-aware facial recognition case study
Published 2023“…However, despite the significant impact of AI design on human interests, the security and trustworthiness of edge AI applications are not foolproof and ethicalneither foolproof nor ethical; Moreover, social norms are often ignored duringin the design, implementation, and deployment of edge AI systems. …”
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YOLO-DefXpert: An Advanced Defect Detection on PCB Surfaces Using Improved YOLOv11 Algorithm
Published 2025“…Compared to the standard YOLOv11 model, the proposed YOLO-DefXpert attained an improvement of 9.3% and 13.2% in mAP50 and mAP95, an 11.25% increase in frames per second, and a 69.85MB decrease in model size. …”
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Driving simulation sickness and the sense of presence: Correlation and contributing factors
Published 2021“…Results showed that females reported significantly higher SS scores than males. An increasing trend in the SS was observed with the increase of age. …”
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Analyzing the Influence of Climate and Anthropogenic Development on Vegetation Cover in the Coastal Ecosystems of GCC
Published 2025“…Our results revealed significant changes in land cover, as seen by an increase in artificial built-up areas by 15.5% in two decades and a corresponding decrease in bareland and dense vegetation. …”
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Do near-bedtime usage of smartphones and problematic internet usage really impact sleep? A study based on objectively recorded usage data
Published 2023“…</p><h3> Results</h3><p dir="ltr">The multivariate linear regression showed that the increase in PIU (β = −0.231, p < 0.001) and smartphone usage two hours before sleep (β = −0.246, p < 0.001) led to decrease in sleep duration. …”