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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Moments-based computation of intermodulation distortion of RF circuits
منشور في 2001"…However, obtaining the IP3 using traditional harmonic balance simulation requires multitone inputs, which significantly increases the computational costs. On the other hand, analytical approaches based on obtaining closed-form expressions for Volterra functional series are too complex to be fully automated for arbitrary circuit topologies. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Systematic analysis of software development in cloud computing perceptions
منشور في 2023"…<p></p><div> <p>Cloud computing is characterized as a shared computing and communication infrastructure. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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An overview of Information and Computer Technology Ethics in the United Arab Emirates
منشور في 2009"…The UAE as a young and quickly rising nation has undergone a fast transformation in a relatively short span of time into a financial, industrial, tourist and strategic hub of the region. With the increasing significance of information and computer technology and the associated risks, it is important to gain insight into both the ethical environment as a whole, and specifically where it applies to information and computer technology. …"
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SVM-based task admission control and computation offloading using lyapunov optimization in heterogeneous MEC network
منشور في 2022"…Results demonstrate high performance gains of the proposed solution that employs SVM-based task admission and Lyapunov-based computation offloading strategies. Significant increase in number of completed tasks, energy savings, and cost reductions are resulted as compared to alternative baseline approaches.…"
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Cloud providers collaboration for a higher service level in cloud computing
منشور في 2013"…Cloud computing is increasingly becoming a desirable and foundational element in international enterprise computing. …"
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Evaluating machine learning technologies for food computing from a data set perspective
منشور في 2023"…It has recently become an important focus of multimedia and social media applications. The rapid increase of available image data and the fast evolution of artificial intelligence, paired with a raised awareness of people’s nutritional habits, have recently led to an emerging field attracting significant attention, called food computing, aimed at performing automatic food analysis. …"
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Sensitivity of endoscopic ultrasound, multidetector computed tomography, and magnetic resonance cholangiopancreatography in the diagnosis of pancreas divisum
منشور في 2013"…On review by expert radiologists, the sensitivity of MDCT increased to 83.3% in cases where the pancreatic duct was visualized, with fair IOA ([kappa] = 0.34). …"
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The Russia-Ukraine war, soaring food prices, and the Turkish economy: insights from computable general equilibrium
منشور في 2023"…The findings reveal significant effects on agricultural imports of crops (wheat, maize, barley, rice, and cereal grains), fruit and vegetables, and oil products, leading to an increase in both import and domestic prices, resulting in food inflation in the country. …"
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Solvent Influence on Absorption Spectra and Tautomeric Equilibria of Symmetric Azomethine‐Functionalized Derivatives: Structural Elucidation and Computational Studies
منشور في 2023"…In contrast, no significant solvent-effect on <b>3 a</b> and <b>3 b</b> was observed. …"
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Combined experimental and computational investigations of the fluorosolvatochromism of chromeno[4,3-b]pyridine derivatives: Effect of the methoxy substitution
منشور في 2023"…The results obtained revealed a significant positive fluorosolvatochromism, with a bathochromic shift in the fluorescence spectrum as the solvent polarity increased. …"