Supplementary file 2_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.jpeg by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Data Sheet 1_SNP rs10748643 determines CD39 expression in T and NK cells through altering NFIC binding affinity rather than interfering with RNA splicing.docx by Chenxin Gan (22750214)

“…Using Cleavage Under Targets and Tagmentation (CUT&Tag) technology, we found that the binding affinity of NFIC decreases when SNP mutates from A to G, causing the reduced inhibition of NFIC on CD39 expression in T cells. …”

Presentation 1_CRIF1 gene therapy ameliorates inflammatory bowel disease by suppressing TH17 cells and fibrosis through mitochondrial function regulation.zip by Jin-Sil Park (294905)

“…Background<p>CR6-interacting factor 1 (CRIF1) is a nuclear transcriptional regulator and a mitochondrial inner membrane protein. …”

Table 2_Proteomic profiling of peripheral blood mononuclear cells reveals immune dysregulation and metabolic alterations in kidney transplant recipients with COVID-19.xlsx by Giuseppe G. F. Leite (18186056)

“…Recently, mass spectrometry-based proteomics has emerged as a powerful tool to shed light on a broad spectrum of dysregulated biological processes in KTRs with COVID-19. …”

Supplementary file 5_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Table 1_Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site.docx by Jinming Wang (191356)

“…</p>Results<p>indicated significant age-related degradation: E_C, σ_Tf, ε_Tf; and MaxForce significantly decreased with age (median E_C declined from 28.0 MPa in young adults to 15.3 MPa in the elderly, P < 0.05; median ε_Tf from 0.215 to 0.156, P < 0.05), while E_E showed no significant age correlation (P = 0.10). …”

Susceptibility of RUNX1 promoter rs2071029 polymorphism to adjuvant chemotherapy-induced neutropenia in CRC by Xikai Luo (21520875)

“…RUNX1 promoter SNP rs2071029T had a decreased risk of severe CIN compared with rs2071029C. …”

Supporting data for <b>Drivers, Composition and Potential for Innovative Vector Control Approaches in the mosquito</b> by Lucy Aliette Janet Mirabib Ame De Guilhem De Lataillade (11192853)

“…</p><p dir="ltr">Brief project description</p><p dir="ltr">Mosquito-borne diseases kill more humans than humans do and have done so for a long time. The most significant diseases transmitted by mosquitoes currently lack effective vaccines, and existing control methods face increasing resistance. …”

Data Sheet 1_Global burden of disease among adolescents and young adults with drug use disorders, 1990–2021: based on GBD 2021.doc by Ming Wang (172316)

“…Additionally, gender plays a significant role in the distribution of this burden, with males experiencing a higher burden than females. …”

Table 2_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …”

Data Sheet 1_Impact of artificial intelligence on electronic health record-related burnouts among healthcare professionals: systematic review.pdf by Berna Sarraf (21651629)

“…Nevertheless, EHR-related workload has been considered as a significant contributor to healthcare professionals’ burnout, a syndrome associated with emotional exhaustion, depersonalization, and reduced personal accomplishment. …”

Table 1_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …”

Table 3_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …”

Table 1_Integrated multi-omics analysis reveals the mechanisms of naringin in ameliorating high-fat diet-induced metabolic dysfunction-associated steatotic liver disease.doc by Wenping Sun (1465360)

“…Lipidomic analysis revealed that Nar restored hepatic lipid homeostasis, significantly decreasing levels of TGs and diglycerides (DGs), with 20 differentially abundant lipid species identified as potential biomarkers. …”

Glutamate dehydrogenase 2 is required for virulence by facilitating fungal growth in the host hemocoel by Yuzhen Lu (4402591)

“…<p><i>Metarhizium robertsii</i>, a fungal pathogen employed in pest biocontrol, can alkalize the surrounding environment, although the biological implications remain unclear. …”

Image 2_Low-frequency electroacupuncture attenuates methamphetamine-induced depressive-like behaviors and cognitive impairment via modulating neuroinflammation.tif by Jingyi Zhang (741111)

“…</p>Methods<p>In this study, a mouse model of METH-induced neuropsychiatric dysfunction was established by administering high-dose METH under elevated ambient temperature. …”

Image 1_Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer.jpeg by Shenglan He (7641308)

“…Consistently, in vitro experiments demonstrated that SB significantly decreased both protein and mRNA levels of α-SMA and POSTN in fibroblasts (colonic myofibroblast CCD-18Co cell lines.) co-cultured with CRC cell lines (human colorectal adenocarcinoma SW480 and RKO cell lines). …”

Spatiotemporal dynamics of sea ice volume and their potential drivers in Liaodong Bay, China, using Sentinel-3 data over five ice seasons by Hongkun Ling (17858516)

“…<p>Global sea ice extent has notably decreased in recent decades due to climate warming. …”

Data Sheet 1_Involvement of long non-coding RNA (lncRNA) MALAT1 in shear stress regulated adipocyte differentiation.docx by Justin Caron (21249173)

“…Our findings indicate that shear stress influences adipocyte differentiation mainly through the downregulation of MALAT1, highlighting a significant interplay between biophysical cues and lncRNAs. …”

Image 6_Low-frequency electroacupuncture attenuates methamphetamine-induced depressive-like behaviors and cognitive impairment via modulating neuroinflammation.tif by Jingyi Zhang (741111)

“…</p>Methods<p>In this study, a mouse model of METH-induced neuropsychiatric dysfunction was established by administering high-dose METH under elevated ambient temperature. …”