Image 3_Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca2+ flux through MAMs.pdf by Yufei Li (433737)

“…It ameliorated MAMs ultrastructure and function, enhancing CypD, MCU, Sig-1R, and NOGO-B expression while reducing IP3R2, GRP75, and VDAC1. in vitro, YQHX significantly increased viability, reduced oxygen-glucose deprivation-induced mPTP opening and Ca²⁺ levels, upregulated CypD, MCU, Sig-1R, and NOGO-B, and downregulated IP3R2, GRP75, and VDAC1. …”

Data Sheet 4_Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca2+ flux through MAMs.pdf by Yufei Li (433737)

“…It ameliorated MAMs ultrastructure and function, enhancing CypD, MCU, Sig-1R, and NOGO-B expression while reducing IP3R2, GRP75, and VDAC1. in vitro, YQHX significantly increased viability, reduced oxygen-glucose deprivation-induced mPTP opening and Ca²⁺ levels, upregulated CypD, MCU, Sig-1R, and NOGO-B, and downregulated IP3R2, GRP75, and VDAC1. …”

Image2_Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis.tif by Zi Yang (276531)

“…The gene expression levels of cytokines and chemokines, including Ccl12, Ccl3, Il1r1, Ccr2, Cx3cr1, Il7, Mmp2, Mmp14, Il1b, and Il7, significantly decreased after treatment with MYDGF, as determined by RNA sequencing. …”

Data Sheet 3_Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca2+ flux through MAMs.pdf by Yufei Li (433737)

“…It ameliorated MAMs ultrastructure and function, enhancing CypD, MCU, Sig-1R, and NOGO-B expression while reducing IP3R2, GRP75, and VDAC1. in vitro, YQHX significantly increased viability, reduced oxygen-glucose deprivation-induced mPTP opening and Ca²⁺ levels, upregulated CypD, MCU, Sig-1R, and NOGO-B, and downregulated IP3R2, GRP75, and VDAC1. …”

SNAP-25 (1-197) binds to syntaxin-1A, and the interaction is enhanced by Ser187 phosphorylation. by Dilara Koc (22431017)

“…<b>(C and D)</b> PMA treatment further decreases neurotransmitter release when a low level of SNAP-25 cleavage is present. …”

Flow chart of the study participants. by Milton W. Musaba (8431944)

“…</p><p>Results</p><p>Bedside resuscitation increased significantly in the post-implementation period (9.3% versus 45.3%, <i>p</i> < 0.001 while early cord clamping decreased (26.7% versus 12.0%, <i>p</i> = 0.042). …”

Suggested modifications for the BabySaver. by Milton W. Musaba (8431944)

“…</p><p>Results</p><p>Bedside resuscitation increased significantly in the post-implementation period (9.3% versus 45.3%, <i>p</i> < 0.001 while early cord clamping decreased (26.7% versus 12.0%, <i>p</i> = 0.042). …”

<i>Irresistible</i>^<i>p173</i> is an allele of the Cadherin-encoding gene <i>cdh16.</i> by Susannah S. Schloss (21238775)

“…<b>(D)</b> <i>cdh16</i>^<i>co79</i> mutants (<i>n</i> = 39) have significantly impaired habituation (****<i>p</i> < 0.0001, Mann–Whitney test) compared to siblings (<i>n</i> = 32). …”

JAK/STAT signaling promotes high global translation rates in CySCs. by Ruoxu Wang (9312306)

“…(C, C′) A wild-type testis showing highest OPP in CySCs adjacent to the hub and decreasing OPP levels with increasing distance from the hub. …”

Figure 7 from KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma by Elisabet Figuerola-Bou (22618659)

“…<p>KDM6B KO decreases tumor growth. <b>A,</b> Colony formation assay of KDM6B KO cells (sgRNA#1 and sgRNA#2) compared with parental and sgCTRL A-673 cells. …”

Image 2_Standardized aqueous extract of Abutilon theophrasti Medic. ameliorates oxidative stress and inflammatory responses against hydrochloric acid/ethanol-induced gastric ulcer... by Hui Guo (110581)

“…In vivo, ATAE markedly attenuated the HCl-/EtOH-induced GU and mucosal injuries; decreased the levels of pro-inflammatory/oxidant mediators, including TNF-α, IL-1β, IL-6, and malondialdehyde (MDA); increased the anti-oxidant activity of mediators superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px); and inhibited the phosphorylation/activation of Akt, IκBα, and NF-κB p65 in gastric tissues. …”

Image 1_Standardized aqueous extract of Abutilon theophrasti Medic. ameliorates oxidative stress and inflammatory responses against hydrochloric acid/ethanol-induced gastric ulcer... by Hui Guo (110581)

“…In vivo, ATAE markedly attenuated the HCl-/EtOH-induced GU and mucosal injuries; decreased the levels of pro-inflammatory/oxidant mediators, including TNF-α, IL-1β, IL-6, and malondialdehyde (MDA); increased the anti-oxidant activity of mediators superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px); and inhibited the phosphorylation/activation of Akt, IκBα, and NF-κB p65 in gastric tissues. …”

Neurodevelopmental deposition of H2AK119ub within acetylated euchromatin. by Aditya Parmar (22331873)

“…<b>(H)</b> Heatmaps depicting H3K27ac CUT&RUN data centered around loci with unchanged, increased, or decreased H2AK119ub. <b>(I)</b> CUT&RUN data for the indicated histone modifications at the indicated timepoints. …”

Data Sheet 1_Efficacy and safety of Tongxinluo capsules combined with conventional therapy for acute myocardial infarction: a systematic review and meta-analysis.zip by Dan Ouyang (554436)

“…The meta-analysis revealed that Tongxinluo capsule combined with conventional treatment significantly decreased the 1-month MACCE rate (RR = 0.62, 95% CI 0.47 to 0.81; p = 0.0007), along with the individual risks of 1-month MACCE, including cardiac death (RR = 0.68, 95% CI 0.50 to 0.93; p = 0.02) and myocardial reinfarction (RR = 0.11, 95% CI 0.01 to 0.94; p = 0.04). …”

Data Sheet 2_Efficacy and safety of Tongxinluo capsules combined with conventional therapy for acute myocardial infarction: a systematic review and meta-analysis.zip by Dan Ouyang (554436)

“…The meta-analysis revealed that Tongxinluo capsule combined with conventional treatment significantly decreased the 1-month MACCE rate (RR = 0.62, 95% CI 0.47 to 0.81; p = 0.0007), along with the individual risks of 1-month MACCE, including cardiac death (RR = 0.68, 95% CI 0.50 to 0.93; p = 0.02) and myocardial reinfarction (RR = 0.11, 95% CI 0.01 to 0.94; p = 0.04). …”

SEAwise synthesis of predicted impacts of changes in habitat and spatial management measures suggested in SEAwise for online tool by Dimitris Damalas (15976639)

“…Such spatial conservation measures will induce negative short-term effects on the fisheries (e.g.: decreased catches and increased operating costs due to effort displacement to surrounding or distant areas) as well as potentially harmful counterproductive effects on biodiversity in some occurrences. …”

VB2 cell fate analysis of <i>hlh-17</i>, <i>hlh-31</i>, and <i>hlh-32</i> mutant animals. by G. Robert Aguilar (13889674)

“…(<b>B</b>) In <i>hlh-17/31/32</i>^null mutants, <i>flp-32(syb4374)</i> reporter allele expression in VB2 is decreased, reaching the same level of expression as that in VB1. …”

Glucose and G-6-P levels modulate HK2-<i>SOX10</i> mRNA association and <i>SOX10</i> mRNA translation. by Ana Luisa Dian (22258504)

“…HK2 and SOX10 protein quantification is normalized to VCL expression, and the data presented as relative to high glucose (500 mM). <i><i>p</i></i>-values were calculated by ordinary two-way ANOVA with Dunnett’s multiple comparisons test (SD, <i>n</i> = 3 biological replicates) and only significant comparisons are shown (* <i>p</i> ≤ 0.05, *** <i>p</i> ≤ 0.001). …”

Additional file 2 of Single-cell profiling reveals periosteal signatures of impaired periosteal cells proliferation in a drill-hole model of type 2 diabetes by Xing Ji (3096735)

“…Impaired callus remodeling and decreased osteogenic activity in db/db mice during fracture healing. …”