Data Sheet 2_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.zip by Xue Li (285380)

“…</p>Results<p>Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. …”

Data Sheet 3_Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca2+ flux through MAMs.pdf by Yufei Li (433737)

“…It ameliorated MAMs ultrastructure and function, enhancing CypD, MCU, Sig-1R, and NOGO-B expression while reducing IP3R2, GRP75, and VDAC1. in vitro, YQHX significantly increased viability, reduced oxygen-glucose deprivation-induced mPTP opening and Ca²⁺ levels, upregulated CypD, MCU, Sig-1R, and NOGO-B, and downregulated IP3R2, GRP75, and VDAC1. …”

Table 5_Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.xls by Xue Li (285380)

“…</p>Results<p>Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. …”

Image 1_Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity.tiff by Matthew C. Austin (20633168)

“…Gene ontology analysis revealed a significant upregulation of pathways involved in inflammatory processes, response to ER stress, and the ER-associated degradation pathway. …”

Image 3_Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity.tiff by Matthew C. Austin (20633168)

“…Gene ontology analysis revealed a significant upregulation of pathways involved in inflammatory processes, response to ER stress, and the ER-associated degradation pathway. …”

Image 4_Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity.tif by Matthew C. Austin (20633168)

“…Gene ontology analysis revealed a significant upregulation of pathways involved in inflammatory processes, response to ER stress, and the ER-associated degradation pathway. …”

Image 2_Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity.tiff by Matthew C. Austin (20633168)

“…Gene ontology analysis revealed a significant upregulation of pathways involved in inflammatory processes, response to ER stress, and the ER-associated degradation pathway. …”

Table 1_Optimal fertilizer rate and sowing density can improve oat quality, yield and N and P comprehensive efficiency in the Loess Plateau of China.docx by Ruochen Zhang (3434996)

“…In the M treatment, the average crude protein (CP) content, relative feed value (RFV), forage yield, CP yield, N content, P content, N uptake and P uptake increased by 20.2%, 4.9%, 73.2%, 100%, 30.4%, 26.3%, 128.5% and 118.4%, respectively, compared with those under the no fertilization treatment; while the average neutral detergent fiber (NDF) decreased by 2.6% in the N1P2 treatment compared to no fertilization treatment. …”

Table 2_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.docx by Rui Jiang (264894)

“…This study aimed to investigate the therapeutic potential of exosomes derived from human classical interscapular brown adipocytes (hcBAC-exos) in alleviating symptoms of RA in a mouse model.</p>Methods<p>We established a mouse model of collagen-induced arthritis (CIA) to evaluate the efficacy of hcBAC-exos. …”

Table 1_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.docx by Rui Jiang (264894)

“…This study aimed to investigate the therapeutic potential of exosomes derived from human classical interscapular brown adipocytes (hcBAC-exos) in alleviating symptoms of RA in a mouse model.</p>Methods<p>We established a mouse model of collagen-induced arthritis (CIA) to evaluate the efficacy of hcBAC-exos. …”

Table 1_Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy.docx by Xiongbao Wang (12508462)

“…Therefore, LAMP1 emerges as a novel biomarker associated with the diagnosis and prognosis of renal cancer. …”

Pathogenicity and transmissibility differences in goose-originated subgenotype 3 duck Tembusu virus in goose embryos and 3-day-old goslings by Ziqiao Zhao (18785775)

“…In the autumn of 2022, an outbreak of an infectious disease resembling DTMUV was reported in Guangdong Province, China, which caused significantly high mortality in goose embryos, and decreased egg production. …”

Table 1_Polygonatum cyrtonema Hua polysaccharides alleviate muscle atrophy and fat lipolysis by regulating the gut microenvironment in chemotherapy-induced cachexia.docx by Rongrong Zhou (3341903)

“…</p><p>Results: This study demonstrated that PCPs significantly mitigated body weight loss, restored muscle fiber atrophy and mitochondrial disorder, alleviated adipose tissue wasting, strengthened the intestinal barrier integrity, and decreased the intestinal inflammation in chemotherapy-induced cachexia. …”

Data Sheet 1_Molecular insights into Atorvastatin’s role in delaying intervertebral disc degeneration.zip by Yupeng Li (507508)

“…Atorvastatin enhanced the antioxidant capacity of NPCs and decreased intracellular ROS accumulation. It promoted Nrf2 activation and upregulated the expression of downstream antioxidant factors, thereby exerting a protective effect against oxidative stress–induced injury. …”

Data Sheet 1_Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning.zip by Shuxian Pan (8868356)

“…Based on machine learning-selected indicators, antiviral therapy and The HBV DNA copy number showed a significant correlation with both the occurrence and severity of irAEs. …”

Hypoxia response and tracheogenesis in <i>PGR</i> mutants. by Daiki Fujinaga (21301129)

“…<p>(A) Relative expression levels of <i>branchless</i> (<i>bnl</i>) in <i>PGR</i> mutants from 0 to 96 hours after puparium formation (APF). …”

Analysis of potential targets of 20S-protopanaxadiol on diabetic nephropathy based on network pharmacology, molecular docking, and experimental validation by Chenfei Li (5921768)

“…<p>This study aims to investigate the protective effects and mechanisms of 20S-protopanaxadiol (PPD), a key component derived from ginseng folium, against diabetic nephropathy (DN).…”

Data Sheet 1_Comprehensive metagenomic and lipidomic analysis showed that baicalin could improve depressive behaviour in atherosclerotic mice by inhibiting nerve cell ferroptosis.z... by Peng Ren (337555)

“…Metabolic pathway enrichment analysis showed that differential lipid PEs were significantly enriched in the iron death pathway, and our further in vitro cellular experiments showed that baicalin could inhibit Erastin-induced Ferroptosis in the hippocampal neuronal cell line HT-22 by promoting the expression of SLC7A11, GSH, and GPX4, inhibiting the expression of ACSL4, and decreasing the cellular ROS.…”

Data Sheet 1_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.pdf by Rui Jiang (264894)

“…This study aimed to investigate the therapeutic potential of exosomes derived from human classical interscapular brown adipocytes (hcBAC-exos) in alleviating symptoms of RA in a mouse model.</p>Methods<p>We established a mouse model of collagen-induced arthritis (CIA) to evaluate the efficacy of hcBAC-exos. …”

Data Sheet 1_Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy.docx by Xiongbao Wang (12508462)

“…Therefore, LAMP1 emerges as a novel biomarker associated with the diagnosis and prognosis of renal cancer. …”