Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications حسب Fang Yu (156838)

"…They further establish the SOCE hypomorph line as a genetic model to define the therapeutic window of SOCE inhibition and dissect toxicities associated with chronic SOCE inhibition in a tissue-specific fashion.</p> <h2>Key points</h2> <ul> <li>A floxed stromal interaction molecule 1 (STIM1) hypomorph mouse model was generated with significant reduction in Ca²⁺ influx through store-operated Ca²⁺ entry (SOCE), resulting in defective nuclear translocation of nuclear factor of activated T cells, cytokine production and inflammatory response. …"

A CFD- RSM study of cuttings transport in non-Newtonian drilling fluids: Impact of operational parameters حسب Abdelrahman M. Awad (16932519)

"…<p dir="ltr">Cuttings removal out of the wellbore represents a real barrier for successful drilling operations. …"

Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma حسب Abou-Ghazal, Mohamed

"…Upon rechallenge, in the animal group that had received WP1066 via o.g., the median survival was 18 days (95% CI: 17, NA), which was significantly different compared to naïve animals challenged at the same time that had a median survival of 11 days (95% CI; 10, NA) (p<0.001); however, there were only 10% long-term survivors suggesting that treatment alone did not generate significant long-term protective immunity. …"
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Theoretical insight into effect of cation–anion pairs on CO₂ reduction on bismuth electrocatalysts حسب Sun Hee Yoon (7179263)

"…This study thus shed light on the positive effects of supporting electrolytes (e.g., CsCl and KCl) on catalytic CO₂RR.</p><h2>Other Information</h2><p dir="ltr">Published in: Applied Surface Science<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.apsusc.2020.147459" target="_blank">https://dx.doi.org/10.1016/j.apsusc.2020.147459</a></p>…"

Preterm birth in low-middle income Countries حسب Alim, Swarray-Deen

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SARS‐CoV‐2 infection triggers more potent antibody‐dependent cellular cytotoxicity (ADCC) responses than mRNA‐, vector‐, and inactivated virus‐based COVID‐19 vaccines حسب Hadeel T. Zedan (12535521)

"…<p dir="ltr">Neutralizing antibodies (NAbs) are elicited after infection and vaccination and have been well studied. …"

Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank حسب Al-Hamdani, Mohammed

"…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R2 = 0.065, ΔF(7, 1724) = 3.34, p = 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …"
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Functional Connectivity Analysis under Vigilance Decrement and Enhanced Mental States حسب Hassanin, Omnia

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Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer حسب Sampath, Lakshmi

"…The tumor-to-muscle ratio decreased in mice pretreated with trastuzumab and in mice injected with IRDye 800CW and (111In-DTPA)p-IgG-(IRDye800)q. …"
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Why some firms export? An empirical analysis for manufacturing firms in the MENA region حسب Fakih, Ali

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Prevalence and risk factors of poor indoor air quality and sick house syndrome symptoms in Dubai حسب ALI, MUNA IBRAHIM

"…Following are the major practical implications and recommendations that can be derived from findings of this research: • Developing related regulations by: o Mandating an appropriate exposure limit for indoor PM2.5 concentration. o Establishing rigorous policies to enforce compliance with mandated limits. o Establishing convenient policies to manage probable environmental risk of incense burning and new paints. o Incorporating the needs of atopic individuals and females in related policies. • Increasing public awareness about below risk factors and how to manage them: o The risk of having unacceptable indoor levels of PM2.5, PM10, TVOC, CO2, T, RH, and AERs that threatens a substantial number of Dubai housing. o The identified IEQ and building risk factors associated with SHS symptoms which were: indoor dimness, dust and dirt, stuffy air, paint odors, high humidity, water leakage, dampness odors, incense smoke, attached kitchens, and Dubai Sector 1. …"
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Investigating the Role of Acetyl-CoA Synthetase Short Chain Family Member 2 (ACSS2) in Inflammatory Bowel Disease: Expression in Clinical Samples and Insights from In Vitro Models حسب Mezher, Nawal

"…Using Caco-2 and HT-29 intestinal epithelial cell lines stimulated with Tumor Necrosis Factor-α (TNF-α) or Dextran Sodium Sulfate (DSS) as in vitro models of inflammation, we observed upregulation of ACSS2 protein expression. ACSS2 inhibition significantly reduced the expression of pro-inflammatory cytokines such as Interleukin 8 (IL-8), IL-1β, and TNF-α, and attenuated activation of NF-κB and MAPK signaling pathways, as evidenced by decreased phosphorylation of p65 and ERK/MEK. …"
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Salvia officinalis water extract: a potential hypolipidemic, hypoglycemic and anti-ulcerogenic remedy حسب Alayan, I.

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Methane production enhancement from Tetraselmis biomass co-digestion using frying oil residue as co-substrate and ultrasonication as pretreatment حسب Firas, Feki

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Which firms export? An empirical analysis for the manufacturing sector in the MENA region حسب Fakih, Ali

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Screening for antiretroviral drug resistance among treatment-naive human immunodeficiency virus type 1-infected individuals in Lebanon حسب Mokhbat, Jacques M.

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Successful endoscopic management of gastrojejunal anastomotic strictures after Roux-en-Y gastric bypas حسب Azar, Riad

"…Dilation to at least 15 mm is safe and decreases the need for further endoscopic dilation.…"
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Evaluation of Lycopus uniflorus water extract for anti-inflammatory, anti-ulcerogenic and antioxidant activities حسب Saade, S.

"…Intra-peritoneal doses of 100 and 200mg/kg BW of the extract showed significant (p &lt;0.05) anti-inflammatory activity when compared with the untreated control. …"
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Photostimulation of Phox2b medullary neurons activates cardiorespiratory function in conscious rats حسب Kanbar, Roy

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Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 حسب Gregory A. Roth (6302315)

"…The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. …"