Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells <i>via</i> Tryptophan 2,3 Dioxygenase حسب Marta Cecchi (21363581)

"…Expression of cancer stem cell markers (CD133, CD44, ganglioside GD2) was significantly increased in A375 spheres, as detected by flow cytometry. …"

A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells حسب Abou-Ghazal, Mohamed K.

"…Although WP1066 did not induce immunological memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (TGF-β, RANTES, MCP-1, VEGF), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …"
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A novel hybrid photovoltaic/thermal-fuel cell system for efficient hydrogen, heat, and power generation: Techno-economic and environmental evaluation حسب Bashar Shboul (22927252)

"…Furthermore, increasing fuel cell temperature from 40 °C to 100 °C significantly improves overall η_PVT-FC and m_PVT-FC, demonstrating the direct impact of thermal regulation on system performance. …"

Absence of cardiac siderosis by MRI T2* despite transfusion burden, hepatic and serum iron overload in Lebanese patients with sickle cell disease حسب Inati, Adlette

"…Background:  The use of magnetic resonance imaging (MRI) to detect organ-specific iron overload is becoming increasingly common. Although hepatic iron overload has been recognized in patients with sickle cell disease (SCD), cardiac iron deposition has only been examined in a few reports. …"
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ROS-Mediated Autophagic Death in Glioblastoma Cells Upon Treatment by Human Recombinant Arginase I (Co)- PEG5000 [HuArgI (Co)-PEG5000] حسب Abdel Khalek, Maya

"…Our results first showed a significant increase in HuArgI (Co)-PEG5000 treated cells for both U251 and A172 in autophagosome formation; suggesting activation of autophagy in response to arginine deprivation. …"
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Exploring the Effect of [HuArgI (Co)-PEG5000]-Induced Autophagy on the Migration, Adhesion, and Invasion of A172 Glioblastoma Cells حسب Oneissi, Zeina

"…Our results show that arginine deprivation significantly activates autophagy in A172 cells, as evidenced by increased autophagosome formation and LC3-II/LC3-I ratios. …"
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SARS‐CoV‐2 omicron variant may present with severe sickle cell painful crisis: A report of two cases حسب Elrazi Ali (14777284)

"…Patients with sickle cell disease infected with SARS-CoV-2 are reported to have increased risk for hospitalization, thrombosis, and other complications compared with non-sickle cell patients. …"

Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia حسب Shilpa Kuttikrishnan (3520079)

"…Curcumin suppresses the viability in a concentration-dependent manner in 697, REH, SupB15, and RS4;11 cells (doses from 0 to 80 μM). Curcumin induces apoptosis in B-Pre-ALL cell lines via activation of caspase-8 and truncation of BID. …"

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway حسب Kirti.S. Prabhu (17191231)

"…Here, we examined the underlying molecular mechanisms of SNG in Non-Small Cell Lung Cancer (NSCLC) cells. SNG suppressed cell growth and induced apoptosis via downregulation of the constitutively active JAK/STAT pathway in all the NSCLC cell lines. siRNA silencing of STAT3 in NSCLC cells further confirmed the involvement of the JAK/STAT signaling cascade. …"

Maternal microbiota and gestational diabetes: impact on infant health حسب Parul Singh (191877)

G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome حسب Francesco Casciello (18557613)

"…CDH10 overexpression significantly reduces cellular movements in breast cancer cell lines and prevents the hypoxia-mediated increase in cell motility. …"

Introducing a Novel Figure of Merit for Evaluating Stability of Perovskite Solar Cells: Utilizing Long Short-Term Memory Neural Networks حسب Zahraa Ismail (22457644)

"…The comparative analysis of model complexity confirmed that increasing the sophistication of the LSTM model significantly enhances predictive accuracy and generalization capabilities. …"

Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy حسب Samson Mathews Samuel (18808246)

"…Treatment with a combination of 2DG (5 mM) and metformin (2 mM) also significantly decreased cell proliferation, migration and tubulogenic capacity when compared to cells that were treated with either 2DG or metformin alone. …"

Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone حسب Ilhame Diboun (3522413)

"…<h3>Background: </h3><p dir="ltr">Paget’s disease of bone (PDB) is characterized by focal areas of dysregulated bone turnover resulting in increased bone loss and abnormal bone formation with variable severity. …"

The anticancer effect of β-2 himachalen-6-ol from Lebanese wild carrot on human acute myeloid leukemia cells. (c2016) حسب Boulos, Joelle C.

"…Cell cycle analysis using flow cytometry revealed an increase in the sub-G1 population. …"
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Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function حسب Muge Sarper (3855454)

"…Over-expression of MMP-8 WT but not MMP-8 EA in β6-1089 cells increased adhesion to ECM proteins and reduced migration. …"

Circulating and Tumor-Infiltrating Immune Checkpoint-Expressing CD8+ Treg/T Cell Subsets and Their Associations with Disease-Free Survival in Colorectal Cancer Patients حسب Alhasan Alsalman (14802873)

"…We found that FoxP3 expression and ICs including PD-1, CTLA-4, TIM-3, and LAG-3 were significantly increased in tumor-infiltrating CD8+ T cells compared with NT and peripheral blood. …"

Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway حسب Olfa Khalifa (10914452)

"…Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. …"

Intratumoral FoxP3⁺Helios⁺ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer حسب Azharuddin Sajid Syed Khaja (19720114)

"…Levels of CD4⁺FoxP3⁺Helios⁺ Tregs were significantly increased in the TME. Furthermore, we observed increased levels of PD-1/CTLA-4 and PD-1/CD39 co-expressing cells within FoxP3⁺Helios⁺ and FoxP3⁺Helios⁻ Treg subsets, indicative of their potent immunosuppressive potential. …"

Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans حسب Kirti S. Prabhu (4246144)

"…We also found that BTZ exerted its antitumor effects by generating reactive oxygen species (ROS), as blocking ROS production significantly reduced BTZ-induced apoptotic cell death. …"