HSP90 inhibition by RGRN-305 decreased the gene expression of proinflammatory cytokines induced by SARS-CoV-2 S protein. by Hakim Ben Abdallah (14578241)

Changes in TEER and permeability of EA.hy926 cells exposed to EVs or pellets from infected or uninfected macrophages. by Myriam Lucia Velandia-Romero (8259726)

“…Interestingly, TEER increased significantly (up to 15 Ω/cm²) when EA.hy926 cells were exposed to EVs obtained from infected U937 macrophages (<i>EV (+)</i>_<i>4G2</i> or <i>P(+))</i> (B). …”

M^pro confers a significant reduction in growth in yeast caused by decreases in a variety of cellular proteins. by Jin Ou (16914305)

Decreased <i>Spn</i> proximity to the nasal epithelium with age. by Kristen L. Lokken-Toyli (9455263)

Subjects:

The miRNA target genes. by Zhaowen Tan (12283502)

“…</p><p>Results</p><p>1) Hemodynamic tests revealed that the blood pressure of SHRs in the BFRT decreased significantly and that the blood pressure level of SHRs in the BFRT decreased more significantly than that of the simple resistance training groups did (P < 0.05). 2) Cardiac function tests revealed that the EF, FS, and MV E/A of SHRs in the BFRT significantly increased, whereas the HR, IVSd, IVSs, LVIDd, LIVDs, LVPWd, LVPWs and LV mass significantly decreased (P < 0.05). 3) Transcriptome sequencing revealed 9 differentially expressed miRNAs in the BFRT group compared with the SHR-SED group (2 miRNAs were significantly upregulated, and 7 miRNAs were significantly downregulated), with P < 0.05 and |log2FoldChange| ≥ 1 used as the criteria for differential significance. …”

miRNA 221 alleviated calcium overload in myocardium and inhibited the expression of apoptosis-related genes in MIRI mice. by Hongyu Li (1332669)

Metabolomic analysis of <i>pgl</i> indicates compensatory changes and decreased pyrimidine metabolism. by Jisun Kim (837555)

Differential Gene Expression Associated with Non-Alcoholic Fatty Liver Disease. by Jiyong Zhang (2498740)

GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age. by Nicole K. Polinski (10947787)

“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”

Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver. by Nicole K. Polinski (10947787)

“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”

The number of significantly downregulated and upregulated differentially expressed genes for all 8 analyses with an p-adjusted value of 0.05. by Michael R. van Gerven (16764526)

Genes significantly affected by deletion of <i>ryfA</i>. by Hicham Bessaiah (6840980)

“…Genes upregulated (yellow rectangles) and downregulated (blue rectangles) by at least 1.7-fold were considered significant with P < 0.05. …”

Highly suspicious variants of uncertain significance (VUS). by Kimberly Gall (11372216)

Pan-cancer analyses of ACADM expression and its prognostic significance in the TCGA database. by Yu Zhang (12946)

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Analysis of the significantly different metabolomic features. by Bhuripit Saraphol (20855573)

Subjects:

MPA does not cause significant apoptosis effect in CN and CO. by Intan Sofia Omar (10451088)

EF-24 treatment significantly reduces cell viability in leukemia cell lines. by Ajeet P. Singh (22298432)

Subjects:

Dose- and time-dependent effect of IL-13, IL-4, and TGF-β1 on benzamil-sensitive <i>I</i>_sc and TEER in HBECs. by Anusree Sasidharan (19226521)

PSG-specific <i>Fzr</i> mutation decreases the expression of silk protein genes. by Wenliang Qian (639395)

“…(<b>B-D</b>) <i>Fzr</i> mutation in the PSG decreased the transcription of silk protein genes, including <i>FibH</i> (B), <i>FibL</i> (C), and <i>P25</i> (D). …”

Details of significantly differentially abundant metabolites (<i>PPP1CC</i>-SSKO vs control). by Jiahong Sun (6497603)