-
621
Effect of national culture on the design of management control systems of multinational enterprises
منشور في 2012"…Companies increasingly need to know whether management control systems or tools that are effective in one national setting will have alternate levels of effectiveness if used in a different national setting. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
article -
622
Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4
منشور في 2023"…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). Concurrently, Ex-4 significantly lowered the expression levels of De novo lipogenesis genes such as SREBP-1, SCD-1and ACC. …"
-
623
Digital Predistortion Using Relaxed Sampling Rates
منشور في 2022احصل على النص الكامل
doctoralThesis -
624
Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling
منشور في 2020"…Even though initially, WTS decreased anxiety-like behaviors it was found that prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. Finally, we showed that nicotine mediates the effects of WTS only on resilience to stress by increasing BDNF and TRKB levels and signaling. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
masterThesis -
625
Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors
منشور في 2023"…The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering blood glucose levels effectively via increasing the glomerular excretion of glucose. …"
-
626
Adapting to Climate Risk? Local Population Dynamics in the United States
منشور في 2024"…Last, we provide evidence of <i>microretreat</i> in the case of <i>coastal flooding</i>: tracts with high levels of this risk have grown significantly less than other tracts in the same county, suggesting that residents are willing to relocate within short distances to avoid predictably risky locations.…"
-
627
Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling
منشور في 2020"…Even though WTS initially decreased anxiety-like behaviors, prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. Finally, we showed that nicotine mediates the effects of WTS only on resilience to stress by increasing BDNF and TRKB levels and signaling. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
article -
628
Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia
منشور في 2023"…The exact mechanisms underlying the initiation and progression of the disease remain to be fully defined. There is an increasing body of evidence for the role of immune dysregulation in the pathogenesis of dementia, where blood-borne autoimmune antibodies have been studied as potential markers associated with pathological mechanisms of dementia. …"
-
629
-
630
Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers
منشور في 2022"…Increasing evidence also suggests that prefibrillar oligomeric species are more toxic than the mature amyloid fibrils. …"
-
631
Adaptive response for climate change challenges for small and vulnerable coastal area (SVCA) countries: Qatar perspective
منشور في 2023"…Long-term mitigation efforts would not help them reduce their current or immediate vulnerability in the short-term, as long as large countries with comparably huge populations, economies, heavy industrial dependences, and extreme consumption levels do not change their courses significantly. …"
-
632
National Culture and Leadership in the United Arab Emirates (UAE)
منشور في 2012"…Globalisation and transferability of human capital across the globe has stimulated an increasing need to develop global managers who understand the implications of cross-cultural work environments and are able to effectively manage people from different cultural backgrounds with diverse cultural values and practices to achieve business success. …"
احصل على النص الكامل
-
633
The Conceptualization, Perceptions, and Practice of Positive Education in University Student Accessibility Departments
منشور في 2023"…This is further supported by literature that states that in spite of the increasing attention toward the growth of positive education, there is still a need to: understand how they are to be implemented in inclusive higher education settings, and to incorporate this educational framework in a more systematic and overt manner. …"
احصل على النص الكامل
-
634
Knowledge and Anxiety about COVID-19 in the State of Qatar, and the Middle East and North Africa Region—A Cross Sectional Study
منشور في 2021"…Good knowledge about COVID-19 was associated with low levels of anxiety. Panic and unfounded anxiety, as well as casual and carefree attitudes, can propel risk taking and mistake-making, thereby increasing vulnerability. …"
-
635
Deep Learning for the Accurate Prediction of Triggered Drug Delivery
منشور في 2024"…The model accurately predicts drug release from liposomes and MOFs under various conditions, including low- and high-frequency ultrasound (extrinsic triggering), microwave exposure (extrinsic triggering), ultraviolet light exposure (extrinsic triggering), and different pH levels (intrinsic triggering). The deep learning-based predictions significantly outperform linear predictions, proving the utility of advanced computational methods in drug delivery. …"
احصل على النص الكامل
article -
636
A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells
منشور في 2008"…The activation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key mediator that drives the fundamental components of melanoma malignancy, including immune suppression in melanoma patients. Increasing evidence also suggests that regulatory T cells (Tregs) are important in suppressing anti-tumor immunity and play a dominant role in negating efficacious immunotherapy approaches. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
article -
637
Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation
منشور في 2025"…In this study, we demonstrate that Prist effectively inhibits the proliferation of T-ALL cell lines (Jurkat and Molt 4) by inducing G0/G1 cell cycle arrest and triggering intrinsic and extrinsic caspase-dependent apoptosis. Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …"
-
638
MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM
منشور في 2020"…Interestingly, interrogation of the expression levels of hsa-miR-205 and hsa-miR-214 in the METABRIC breast cancer dataset revealed significantly poor overall survival in patients with downregulated expression of miR-205 [HR = 0.75 (0.61–0.91)], p = 0.003 and hsa-miR-214 [HR = 0.74 (0.59–0.93) p = 0.008]. …"