Supplementary file 1_Temporal interaction information and laser evoked responses: preliminary results in fibromyalgia patients with small fibers pathology.docx by Livio Clemente (22152382)

“…</p>Results<p>Control subjects generally exhibited synergy clusters corresponding to N2 and P2 peaks, whereas patients with fibromyalgia (FM), particularly those with distal denervation, exhibited increased redundancy and decreased synergy.</p>Conclusion<p>Patients with FM and small fiber pathology exhibited an alteration in higher-order integration mechanisms due to a complex interaction between cortical processing of pain and denervation of nociceptive fibers.…”

Juvenile demyelination induces a loss of functional autapses. by Sara Hijazi (21656615)

“…Cuprizone-treated mice show a significant decrease in the percentage of cells showing an autaptic response (<i>Fisher’s exact test; *p = 0.0173</i>). …”

AUT00201 (1 µM) can rescue AP width in cuprizone mice. by Sara Hijazi (21656615)

“…In the responsive cells from cuprizone mice (red) a significant increase in PV interneuron firing frequency at lower current steps (gray) was observed (<i>group x current two-way repeated measures: n = 8 cells from 4 mice: p = 0.05287; AUT00201 effect: F(1,60) = 5.050, *p = 0.0457. …”

Autapses play a crucial role in PV interneuron’s sustained firing at high frequencies. by Sara Hijazi (21656615)

“…Average action potential (AP) frequency in response to 0−650 pA current steps illustrating a significant increase in PV interneuron firing frequency at low-current steps in control cells without autapses (gray) compared to control cells with autapses (black). …”

Comparison between juvenile and adult demyelination. by Sara Hijazi (21656615)

“…Juvenile demyelination leads to impairment in PV interneuron maturation whereas adult demyelination induces a decrease in the excitability of PV interneurons. Summary data showing the averaged (± s.e.m) of the following intrinsic properties: (A) Resting membrane potential (RMP) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: *p < 0.05, **p < 0.01, ****p < 0.0001</i>), (B) Input resistance (IR) (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0024, post-hoc LSD test: *p < 0.05, **p < 0.01, ***p < 0.001</i>), (C) Sag (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0083, post-hoc LSD test: *p < 0.05, **p < 0.01</i>), (D) Rheobase (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, p = 0.1230, post-hoc LSD test: *p < 0.05</i>) and (E) Action potential (AP) threshold (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, *p = 0.0452, post-hoc LSD test: *p < 0.05</i>), (F) AP half-width (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, **p = 0.0058, post-hoc LSD test: **p < 0.01</i>), (G) Average action potential (AP) frequency in response to 0–650 pA current steps illustrating no significant change in S1 PV interneuron firing frequency following juvenile demyelination (<i>group x current two-way repeated measures: n = 36,30,19,24 cells from 9/8/8/6 mice per group: F(39,1,291) = 2.487, ****p < 0.0001</i>) and (H) Maximum firing frequency per group (<i>ANOVA: n = 36,30,19,24 cells from 9/8/8/6 mice per group, ****p < 0.0001, post-hoc LSD test: ***p < 0.001, ****p < 0.0001</i>). …”

Bar chart of state-wise annual temperature shift. by MD. Nahid Hassan Nishan (22264861)

“…Improvements in educational attainment, particularly higher education levels, were strongly linked to earlier menarche, indicating that demographic changes had a significant influence. …”

Demographic characteristics of the participants. by MD. Nahid Hassan Nishan (22264861)

“…Improvements in educational attainment, particularly higher education levels, were strongly linked to earlier menarche, indicating that demographic changes had a significant influence. …”

Covid Mzt. by Francisco Flores-de-Santiago (20391063)

“…Canonical analysis of principal coordinates during the lockdown year revealed two key patterns: (1) sewage and harbor areas displayed a significant decrease in CHLA levels alongside elevated TSMC2, while (2) mangrove forest exhibited markedly reduced CDOM in post-pandemic years. …”

Table 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.docx by Nourhen Agrebi (14151222)

“…Background<p>Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations complicate diagnosis and management.…”

Comparison of circulating biomarkers among PHIVAYA subgroups. by Maria Raffaella Petrara (4446358)

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Flow cytometry gating strategy for (A) total lymphocytes on morphological parameters forward scatter (FSC) and side scatter (SSC); within the lymphocyte gate, selection on FSC-heig... by Maria Raffaella Petrara (4446358)

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Schematic representation of the studied populations at the time of study sampling. by Maria Raffaella Petrara (4446358)

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Schematic pathogenetic pathway of how persistent HIV reservoir may lead to premature aging and precocious onset of aging-related comorbidities. by Maria Raffaella Petrara (4446358)

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Immunological and cellular aging biomarkers of Early Suppressed (ES)- and Late Suppressed (LS)-PHIVAYA. by Maria Raffaella Petrara (4446358)

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Comparison of markers of aging among PHIVAYA groups and healthy controls. by Maria Raffaella Petrara (4446358)

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Comparison of immune and cellular markers of aging among PHIVAYA subgroups. by Maria Raffaella Petrara (4446358)

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Immunological and cellular aging biomarkers in Suppressed (S) and Not Suppressed (NS) PHIVAYA. by Maria Raffaella Petrara (4446358)

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Correlation plot between HIV reservoir and immune and cellular markers in PHIVAYA. by Maria Raffaella Petrara (4446358)

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Characteristics of the studied populations at the time of study sampling. by Maria Raffaella Petrara (4446358)

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Serum metabolomic response to aging. by Gwangho Yoon (5771678)