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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines
Published 2022“…Evaluating the effect of CBD combined with paclitaxel against SK-OV-3 cell line demonstrated antagonism on all relevant inhibitory effect levels. Nonetheless, priming SK-OV-3 cells with CBD for 24h to sensitize them to the effect of cisplatin or paclitaxel treatment has shown to decrease the IC50 of the chemotherapeutic drugs. …”
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Exploring beyond numeric weight loss: The metabolic effects of semaglutide
Published 2025“…Semaglutide also slowed weight regain and promoted weight loss after failed <u>bariatric surgery.</u> It also significantly reduced ad libitum <u>energy intake</u>, decreased hunger, and increased satiety in multiple trials. …”
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Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains
Published 1991“…Decreased striatal dopamine levels in these latter rat strains were associated with increased dopamine turnover. …”
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Multilayer Reversible Data Hiding Based on the Difference Expansion Method Using Multilevel Thresholding of Host Images Based on the Slime Mould Algorithm
Published 2022“…In the DE-based RDH method, finding spaces that create less distortion in the marked image is a significant challenge, and has a high insertion capacity. …”
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An Investigation into the factors influencing Arabic speaking students’ proficiency in the Arabic language in Dubai British School
Published 2022“…This is likely due to the difference in linguistic environment experienced by the students in the British schools, relative to those in the Arabic schools, and which this study significantly correlated with decreased proficiency. …”
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Wound healing potential of quercetin-3-O-rhamnoside and myricetin-3-O-rhamnoside isolated from Pistacia lentiscus distilled leaves in rats model
Published 2022“…Indeed, the level of the inflammatory protein CRP is significantly lower in groups treated with MM and QM than in the negative control group. …”
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Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
Published 2020“…Stretching the RPV also significantly increased ROS generation after 1 hour, whereas APN significantly decreased mechanical stretch-induced ROS production. …”
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Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort
Published 2024“…Elevated QTc was observed in CAD patients, whereas decreased QTc was correlated with decreased levels of calcium and potassium. …”
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Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
Published 2019“…Cells were co-transfected with a C-terminal modified α-synuclein (SynT) and synphilin-1, and then treated with DHM (10 μM) and Sal B (50 μM) 16 hours after transfection; levels of α-synuclein aggregation decreased significantly (68% for DHM and 75% for Sal B). …”
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Assessment of High-resolution Local Emissions and Land-use in Air Quality Forecasting at an Urban, Coastal, Desert Environment
Published 2022“…The use of the local emissions allowed for a significant improvement in the representation of air quality levels in the city. …”
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Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019
Published 2023“…FindingsIn contrast with the decreasing trend of HF burden globally, EMR showed an increasing trend. …”
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Depression, anxiety and obsessive–compulsive symptoms in relation to nutritional status and outcome in severe anorexia nervosa
Published 2012“…Future studies should use a better indicator for nutritional status than BMI alone, and should also consider the initial degree of weight loss and the rate at which weight was lost.…”
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A novel hybrid methodology for fault diagnosis of wind energy conversion systems
Published 2023“…Then, the sensitive and significant characteristics are transmitted to the RF model for classification purposes. …”
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
Published 2020“…When compared to control specimens, evaluation of epigenetic alterations in rat tumor cells in vivo showed significant dose-dependent decrease in lysine methylation status of H3K4m3 and H3K9m3 and dose-dependent increase in lysine acetylation in H4K16ac levels (H4K20m3 was not changed) in treated groups. …”
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Activation of Src kinase in primary colorectal carcinoma An indicator of poor clinical prognosis
Published 2002“…RESULTS By CART analysis, Src activity in tumors elevated more than twofold over normal mucosa was significant. Increased Src activity significantly correlated with Dukes stage, pT and pN classification, and increased u-PAR levels (P < 0.001). …”
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IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
Published 2002“…Neither IL-1 nor ceramide induced apoptosis in IEC, but they increased bcl-2 levels and decreased bax and p21 levels without affecting bcl-x and p53 levels. …”
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Dynamic Performance Investigation of Solar‐Driven Vapor Absorption Cooling System for Urban Areas
Published 2025“…For both flat plate and ETCs, increasing the collector area increased the SF and primary energy savings while increasing the capacity of thermal storage decreased the SF and primary energy savings. For varying thermal storage volumes, the SF varies very little when using flat plate collector but significantly when using ETC. …”
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
Published 2025“…As well, the expression levels of 20-HETE, Il-1β and TNF-α were decreased in LPS-challenged RAW264.7 macrophages upon treatment with compound 2a. …”
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