A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells by Abou-Ghazal, Mohamed K.

“…Moreover, CD3+ T cells exhibited markedly enhanced levels of phosphorylated ZAP-70, a critical proximal signal in T cell activation, after exposure to WP1066. …”
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…In this study, we demonstrate that Prist effectively inhibits the proliferation of T-ALL cell lines (Jurkat and Molt 4) by inducing G0/G1 cell cycle arrest and triggering intrinsic and extrinsic caspase-dependent apoptosis. Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

Long-Chain Acyl-CoA Synthetase 1 Role in Sepsis and Immunity: Perspectives From a Parallel Review of Public Transcriptome Datasets and of the Literature by Jessica Roelands (7516439)

“…Furthermore, available clinical data indicate that levels of ACSL1 and ACSL4 induction was significantly higher in fatal cases of sepsis. …”

Children diabetes prevention camps by Nature Research (16552612)

“…These percentages are significantly higher than the region’s average (13% and 24.5%, respectively). …”

Perceptions and Practices Related to Twice-Exceptional Learners in K-12 American Private Schools in Dubai by FAKIH, MIRNA KHALIL

“…Results of the study have revealed that stakeholders and K–12 teachers have shown different perceptions, experiences, and low levels of awareness towards the education of twice-exceptional learners due to many factors and challenges. …”
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Risk Factors for Post-Cesarean, Surgical Site Infections in a Multi-Ethnic Population of Qatar by Sufia Athar (14777830)

“…</p><h3>Conclusion</h3><p dir="ltr">This study provides baseline levels for SSI after CD across several different patient subgroups. …”

The Race to Electric Vehicles by Saliba, Jerome

“…The number of electric vehicles on the roads increased from a few thousand in 2010 to more than 10 million in 2020.1 Electric vehicles have already become a major element of modern transportation and may even replace traditional internal combustion engine vehicles before we know it.2 As a rising industry, electric vehicles manufacturing has been subject to national policy in many countries around the world. …”
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Dynamics of Muslim consumers’ behavior toward Halal products by Osama Sam Al-Kwifi (18061030)

“…</p><h3>Findings</h3><p dir="ltr">Across all participants, the level of brain activation in the ventromedial prefrontal cortex increased significantly when Halal images were presented to them. …”

Environmental movement in Lebanon by Djoundourian, Salpie

“…Using the total number of established environmental organizations and the level of reported activities aimed at spreading environmental awareness and educating people as indicators of private sector involvement in the environmental movement, the paper concludes that the post war era is characterized by a significant increase in the number of established organizations. …”
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E-cigarettes in the Middle East: The known, unknown, and what needs to be known next by Mohammed, Al-Hamdani

“…The prevalence of electronic cigarettes (e-cigarettes) is increasing globally. Population-level data from several nations suggest that a higher proportion of youth and young adults are using e-cigarettes compared to the general population. …”
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Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia by Hanan Ehtewish (17149825)

“…And 20 proteins had significantly altered autoantibody responses in MCI compared to cognitively normal individuals. …”

Deep Learning for the Accurate Prediction of Triggered Drug Delivery by Husseini, Ghaleb

“…The model accurately predicts drug release from liposomes and MOFs under various conditions, including low- and high-frequency ultrasound (extrinsic triggering), microwave exposure (extrinsic triggering), ultraviolet light exposure (extrinsic triggering), and different pH levels (intrinsic triggering). The deep learning-based predictions significantly outperform linear predictions, proving the utility of advanced computational methods in drug delivery. …”
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Willingness to Pay for Clean Air: Evidence from the UK by Maarraoui, Giorgio

“…The willingness to pay for clean air is also significant and increases with level of education. These measurements derived can be used as benchmarks for pollution abatement subsidies or pollution taxes and can help in projecting a more comprehensive assessment of costs and benefits.…”
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Construction workforce management strategies to reduce absenteeism by Lattouf, M. Ghayth

“…Despite the international location of the survey, the results indicate a worker demographic similar to that found in the southwestern United States and other areas with significant residential construction. The results also serve to highlight the significance of basic management techniques in reducing absenteeism: adopting training programs to increase the skill level of workers, providing incentives to increase the tenure of workers onsite, and arranging the working schedule to favor less overtime.…”
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Synthesis and analysis of silver–copper alloy nanoparticles of different ratios manifest anticancer activity in breast cancer cells by Sara Al Tamimi (9692615)

“…Furthermore, we observed the cell death pathway by the apoptosis marker Annexin-V which showed non-significant results, while the exposure of AgCu-NP in MCF-7 cells leads to toxicity and also caused significant increase in MMP-9 level, which suggests the cell death may be associated with other pathways such as autophagy and oxidative stress related.…”

How FIFA World Cup 2022™ can meet the carbon neutral commitments and the United Nations 2030 Agenda for Sustainable Development?: Reflections from the tree nursery project in Qatar... by Ioannis Spanos (2086933)

“…Tree nurseries with stress-tolerant variants play a significant role in cutting the excess emissions from Qatar 2022, thereby supporting long-term sustainable development. …”

Unsustainability in emergent systems by Haddad, Marc

“…These challenges are already significant enough to seriously hamper the network's ability to deliver an acceptable level of service within reasonable norms for environmental, health and safety impacts, especially in and around the country's major urban centers. …”
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Cost analysis of agricultural greenhouse yield production using spectrum selective fluids by Muhammad Usman Sajid (14778232)

“…<p dir="ltr">As global food demand rises, there is an increasing emphasis on local food production, especially in arid regions where traditional farming is limited. …”

Managing span of control efficiency and effectiveness by El-Kassar, Abdul-Nasser

“…Purpose The purpose of this paper is to address the following issues: first, the significance of the three independent variables (the chassis, trim, and assembly departments) on the three outputs (direct run loss first time capability, jobs per hour (JPH) lost, and injury rate); second, the optimal level of span of control based on the best achieved outputs; and third, whether increasing the span of control post 2009 improved manufacturing outputs in comparison with a span of control pre 2009. …”
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Beyond genetics: Exploring the role of epigenetic alterations in breast cancer by Kirti S. Prabhu (4246144)

“…<p>Breast cancer remains a major global health challenge. Its rising incidence is attributed to factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug resistance, all contributing to less-than-ideal patient outcomes. …”