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significant mean » significant main (Expand Search), significant green (Expand Search), significant gap (Expand Search)
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19601
Table 1_Evaluation of mesenchymal stem cells as an in vitro model for inherited retinal diseases.docx
Published 2024“…In the preclinical research phase, in vitro models complement in vivo models by reducing animal studies, decreasing costs, and shortening research timelines. …”
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19602
Glutamate dehydrogenase 2 is required for virulence by facilitating fungal growth in the host hemocoel
Published 2025“…Loss of <i>MrGDH2</i> function resulted in significantly reduced virulence during both cuticle-passing and cuticle-bypassing infections but did not affect appressorium formation or cuticle penetration. …”
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19603
Image 1_3KO-NSCs ameliorate behavioral deficits and modulate gut microbiota in a VPA-induced C57BL/6 mouse model of autism.tif
Published 2025“…</p>Results<p>3KO-hiPSC-NSC treatment significantly ameliorated VPA-induced ASD-like behaviors. …”
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19604
Image 7_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.tif
Published 2025“…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…”
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19605
Table 1_Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study.docx
Published 2025“…</p>Results<p>Among 67 patients analyzed, LSG significantly decreased serum concentrations of arginine, alanine, threonine, glutamic acid, branched-chain amino acids (valine, isoleucine, leucine), and aromatic amino acids (tyrosine, phenylalanine, tryptophan) (p < 0.05), while serine and glycine increased (p < 0.05). …”
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19606
Data for: Drought and temperature stresses impact pollen production and autonomous selfing in a California wildflower, Collinsia heterophylla
Published 2025“…In nature, such responses will likely reduce available nutrition for pollinators through decreased flower and pollen production.</p><p>The included data file can be opened with any spreadsheet software including MS Excel or Google Sheets.…”
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19607
Image 4_Photon budgets and the relative effects of CDOM and pigment absorptions on primary production along a coastal salinity gradient.jpeg
Published 2025“…The absorption by CDOM and detritus decreased with increasing salinity, while phytoplankton absorption followed a seasonal succession. …”
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19608
Image 2_Low-frequency electroacupuncture attenuates methamphetamine-induced depressive-like behaviors and cognitive impairment via modulating neuroinflammation.tif
Published 2025“…</p>Results<p>Behavioral tests revealed that low-frequency EA significantly alleviated depressive-like behaviors and cognitive impairment. …”
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19609
Image 1_PCP4 inhibits the progression of prostate cancer through Ca2+/CAMKK2/AMPK/AR pathway.jpeg
Published 2025“…</p>Conclusion<p>Our findings elucidate the molecular mechanism that PCP4 downregulation promotes PCa progression via Ca<sup>2+</sup>/CAMKK2/AMPK/AR pathway, highlighting its significance in CRPC development.</p>…”
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19610
Table 2_Clinical features and genetic analysis of acrodermatitis enteropathica in an ethnic minority infant from Western China: a case report and literature review.xlsx
Published 2025“…Her serum zinc level significantly decreased (0.19 mg/L). Whole-exome sequencing revealed a homozygous c.197G > T(p. …”
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19611
Navigation error analysis.
Published 2025“…Results show that SIDFM reduces navigation errors by 12.09% at low acceleration and 11.43% at high acceleration while also significantly decreasing positioning errors. These improvements enhance the stability, precision, and safety of AGVs in dynamic manufacturing environments. …”
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19612
Supplementary file 1_Integrated transcriptomic analysis of COVID-19 stages and recovery: insights into key gene signatures, immune features, and diagnostic biomarkers through machi...
Published 2025“…Recovery analysis showed significantly reduced adaptive immune cells at 1 month, with partial recovery by 3 and 6 months. …”
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19613
Image 6_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg
Published 2025“…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…”
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19614
Raw data WB.pdf
Published 2025“…Moreover, miR-369-3p significantly decreased the release of pro-inflammatory cytokine IL-8. …”
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19615
Image 2_GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma.tif
Published 2024“…The expression of G protein–coupled estrogen receptor 1 (GPER1), a non-classical estrogen receptor, was significantly decreased in proliferating macrophages, and was inversely correlated with macrophage proliferation in HCC tumors. …”
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19616
Base-case results.
Published 2024“…Clinical findings have showed that deprescribing service significantly decreased inappropriate PPIs utilization. …”
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19617
Image 1_Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer.jpeg
Published 2025“…Consistently, in vitro experiments demonstrated that SB significantly decreased both protein and mRNA levels of α-SMA and POSTN in fibroblasts (colonic myofibroblast CCD-18Co cell lines.) co-cultured with CRC cell lines (human colorectal adenocarcinoma SW480 and RKO cell lines). …”
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19618
Supplementary file 1_IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema.d...
Published 2025“…These results suggest that MSCs significantly promote the proliferation of LEPCs through the activation of the PI3K/Akt/mTOR pathway in LEPCs by secreting IGF-1, and that IGF-1 also inhibits apoptosis and regulates cell metabolism. …”
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19619
Table 1_Multi-omics analysis reveals that low cathepsin S expression aggravates sepsis progression and worse prognosis via inducing monocyte polarization.xlsx
Published 2025“…Inflammatory markers (p < 0.05) and migration ability of LPS-activated monocytes were significantly reduced after CTSS agonist. In addition, CTSS agonist decreased the pulmonary tissue monocyte/macrophages infiltration in septic mice.…”
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19620
DataSheet1_Study on the effects of laser shock peening on the microstructure and properties of 17-7PH stainless steel.docx
Published 2024“…The microhardness of the specimens shows a decreasing trend with increasing power density. When the power density is 2.79 GW/cm<sup>2</sup>, the microhardness of the specimen significantly increases to 462.94 HV0.5, which is 22.26% higher than that of the non-peened specimen.…”