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largest decrease » marked decrease (Expand Search)
significant new » significant non (Expand Search), significant genes (Expand Search), significant anti (Expand Search)
larger decrease » marked decrease (Expand Search)
new decrease » nn decrease (Expand Search), we decrease (Expand Search), mean decrease (Expand Search)
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2521
<i>Eggerthella lenta</i> down regulated flavone and flavonol biosynthesis promoted Kawasaki disease
Published 2025“…Alpha (<i>p</i> < 0.042) and beta (<i>p</i> < 0.001) diversity in KD were significantly decreased when compared to the control group. …”
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2522
Data Sheet 1_Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway.docx
Published 2025“…It also decreased Aβ deposition and ameliorated neuronal apoptosis in the cerebral cortex. …”
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2523
<b>Tracking incidence classification changes across disturbances at Konza Prairie LTER</b>
Published 2025“…Plants had the most populations classified as directed change (increasing=241/253, decreasing=95/101). The grazing press disturbance hypothesis was partially supported for plant taxa, which significantly differed by watershed treatments (Chi-square, p=3.182e-11). …”
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2524
<i>Edwardsiella piscicida</i> employs C3 derivative to mediate internalization and infection via the teleost-specific receptor
Published 2025“…When PoCD18 was knocked down or blocked, bacterial infection and tissue lesions were significantly decreased. Mechanistically, the intracellular domain of PoCD18 subsequently interacted with PoCytohesin and triggered the phosphorylation of the phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase (Akt) signalling pathway. …”
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2525
Data Sheet 1_Autoimmune thyroid disease and human health: a systematic review of Mendelian randomization studies.xlsx
Published 2025“…MR analyses indicated that AITD significantly increased the risk of coronary atherosclerosis, deep venous thrombosis, chronic obstructive pulmonary disease, major depression, diabetic neuropathy, carpal tunnel syndrome, neuromyelitis optica spectrum disorder, diabetic retinopathy, childhood absence epilepsy, rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, inflammatory bowel disease, crohn's disease, vitiligo, myasthenia gravis, alopecia areata, type 1 and type 2 diabetes, sarcoidosis, frozen shoulder, drug eruptions, cataract, early age-related macular degeneration, pernicious anemia, Helicobacter pylori infection, temporomandibular disorders, migraine, frailty, primary biliary cholangitis, knee osteoarthritis, gout, and osteoporosis, while decreasing the risk of lung cancer, polyneuropathies, allergic rhinitis, telomere length, and serum vitamin A levels. …”
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2526
Supplementary file 2_Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.docx
Published 2025“…The data analysis results indicated that the disease activity index (DAI), histopathological score (HS), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and myeloperoxidase (MPO) activity in the IBD animal models significantly decreased following intervention with oxymatrine. …”
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2527
Table 1_Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.docx
Published 2025“…The data analysis results indicated that the disease activity index (DAI), histopathological score (HS), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and myeloperoxidase (MPO) activity in the IBD animal models significantly decreased following intervention with oxymatrine. …”
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2528
Tilmicosin inhibits the infections of currently prevalent porcine reproductive and respiratory syndrome viruses via the downregulation of CD163 expression
Published 2025“…Flow cytometric analysis indicated that anti-inflammatory may reverse the downregulation effect of tilmicosin on CD163, while pro-inflammatory mediators can enhance the downregulation effect of tilmicosin on CD163, which leads to increased and decreased replication of PRRSV, respectively. These findings demonstrate that tilmicosin can inhibit PRRSV replication via the reduction of CD163 expression, which provides new insights into anti-PRRSV mechanisms of tilmicosin.…”
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2529
Table 1_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.xls
Published 2024“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”
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2530
Table_2_ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1.docx
Published 2025“…Results from immunohistochemistry show that the expression of ATG5 and ATG7 is significantly reduced in melanoma tissues compared to benign nevi. …”
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2531
Table 1_MFN2-a multifaceted guardian against Parkinson’s pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.docx
Published 2025“…</p>Results<p>In PD models, the expressions of DHODH, MFN1, MFN2, GPX4, and FSP1 were significantly down-regulated, and their motor coordination, self-cognitive behavior, and exploration ability were decreased. …”
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2532
Image 13_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg
Published 2024“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”
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2533
Image 1_Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion.pdf
Published 2025“…This finding indicates a new important potential target for the treatment of UC.…”
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2534
Image 1_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg
Published 2024“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”
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2535
Table 1_Akkermansia muciniphila alleviates cognitive impairment and neuroinflammation induced by blunt chest trauma.docx
Published 2025“…Targeting the gut-brain axis may offer new strategies for preventing and treating trauma-induced neurological disorders.…”
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2536
Supplementary file 3_Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.docx
Published 2025“…The data analysis results indicated that the disease activity index (DAI), histopathological score (HS), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB), and myeloperoxidase (MPO) activity in the IBD animal models significantly decreased following intervention with oxymatrine. …”
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2537
Image 12_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg
Published 2024“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”
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2538
<b>Mystery of Deep Soil Organic Carbon Dynamics Uncovered through Long-term Conservation Tillage Experiments</b>
Published 2025“…Our findings suggest that long-term NT in boreal <a href="" target="_blank">agroecosystem</a>s affects SOC dynamics in both topsoil and deep soil, providing new insights into carbon sequestration under long-term conservation tillage. …”
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2539
Image 11_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg
Published 2024“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”
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2540
Image 2_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg
Published 2024“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”