Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice حسب Julie Decock (44558)

"…No differences in macrophage infiltration were apparent throughout primary tumor development, though at 10 weeks a drop in neutrophil infiltrates was observed in Mmp8-wild-type tumors. Using quantitative real-time RT-PCR, we tracked the expression of the entire Mmp and Timp gene families, observing a significant decrease in Mmp3 expression in Mmp8-null tumors compared to wild-type and heterozygotes throughout the time course of the model, which was confirmed at the protein level. …"

Detecting Mental Stress using EEG and Deep Learning حسب Badr, Yara

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Nox2 Activity Is Required in Obesity-Mediated Alteration of Bone Remodeling حسب Md Mizanur Rahman (14603354)

"…HFD also significantly increased the number of adipocytes in the bone marrow microenvironment of WT mice as compared to KO mice. …"

Nurses’ work environment and intent to leave in Lebanese hospitals حسب Dimassi, Hani

"…Likewise, for every 1 point score decrease on participation there was an observed 51% and 53% increase in likelihood of reporting intent to leave country and hospital, respectively. …"
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High flow nasal oxygen (HFNO) in the treatment of COVID-19 infection of adult patients from – An emergency perspective: A systematic review and meta-analysis حسب Nabil Shallik (15900256)

"…HFNO was associated with a significant decrease in mortality and intubation rates (0.28 (95% CI; 0.19, 0.39) and 0.28 (95% CI; 0.18, 0.41), respectively). …"

Prospective, randomized, crossover study to evaluate the benefit of human chorionic gonadotropin-timed versus urinary luteinizing hormone-timed intrauterine inseminations in clomip... حسب Zreik, Tony

"…The pregnancy rate with LH-timed IUI was 4.29% (3/70) and that with hCG-induced ovulation was 4.23% (3/71); the difference was not statistically significant. …"
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Acute intense fatigue does not modify the effect of EVA and TPU custom foot orthoses on running mechanics, running economy and perceived comfort حسب Ken Van Alsenoy (14150559)

"…There was a global fatigue-induced deterioration in running economy (− 1.6 ± 0.4%; P < 0.001). …"

Tryptophanyl-tRNA synthetase-1 (WARS-1) depletion and high tryptophan concentration lead to genomic instability in Caenorhabditis elegans حسب Mahmoud Izadi (12899508)

"…Our result demonstrates that exposing C. elegans to a high tryptophan dosage leads to DNA damage checkpoint activation and a significant increase in the tryptophan metabolites. …"

Effect of temperature on the rheological properties of neat aqueous Wyoming sodium bentonite dispersions حسب Vryzas, Zisis

"…Temperature affects significantly the rheological behavior of neat water Wyoming Na-bentonite dispersions. …"
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Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute... حسب Farhat, Mirna

"…We showed evidence that PAU2R200A/FP59, from the IMC variant, induced a cytotoxic response that matched the pattern of IMC/FP59, as such indicating that uPA/uPAR is the rate limiting factor in the activation of IMC/FP59.In addition, staining for Annexin V/PI post IMC/FP59 treatment showed an increase in double positive cells indicating non-apoptotic cell death. …"
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Is embolization of segment 4 portal veins before extended right hepatectomy justified? حسب Kishi, Yoji

"…Results After a median of 27 days, the S2+3 volume increased significantly after both RPVE and RPVE+4, but the absolute increase was significantly higher for RPVE+4 (median, 106 mL vs 141 mL; P = .044), as was the hypertrophy rate (median, 26% vs 54%; P = .021). …"
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Towards secure private and trustworthy human-centric embedded machine learning: An emotion-aware facial recognition case study حسب Muhammad Atif Butt (10849980)

"…However, despite the significant impact of AI design on human interests, the security and trustworthiness of edge AI applications are not foolproof and ethicalneither foolproof nor ethical; Moreover, social norms are often ignored duringin the design, implementation, and deployment of edge AI systems. …"

Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mi... حسب Bogachev, Oleg

"…Moreover, AEBP1 has been shown to promote macrophage inflammatory responsiveness by inducing nuclear factor (NF)-κB activity via IκBα downregulation. …"
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Investigating the Therapeutic Effects of Small Molecule Imipridones In Pediatric Neuroblastoma حسب El Soussi, Sarra

"…Drug treatment in these cells significantly reduced cellular proliferation, viability, migration and increased apoptosis. …"
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Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway حسب Olfa Khalifa (10914452)

"…Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. …"

Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer حسب Shebaby, Wassim N.

"…Additionally, F2 fraction treatment caused an up-regulation of the expression of pro-apoptotic (Bax) and down-regulation of the expression of anti-apoptotic (Bcl2) proteins. A decrease in the phosphorylation of AKT and ERK was also observed. …"
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Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway حسب Kirti.S. Prabhu (17191231)

"…<p dir="ltr">Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. …"

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance حسب Gh Rasool Bhat (13038132)

"…These processes are pivotal in the development and progression of tumors, contributing to the multifaceted nature of cancer and the challenges associated with its treatment. Despite significant advancements in targeted therapies, cancer cell adaptability and subsequent therapy-induced resistance remain persistent obstacles in achieving consistent, successful cancer treatment outcomes. …"

Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy حسب Adviti Naik (673163)

"…Silencing LDHC in four breast cancer cell lines significantly increased the presence of giant cells, nuclear aberrations, DNA damage, and apoptosis. …"

Comparative Effect of Sodium Butyrate and Sodium Propionate on Proliferation, Cell Cycle and Apoptosis in Ovarian Cancer Cells حسب Danaf, Daniella

"…The mechanism of cell death induced by NaB and NaP was assessed using Annexin V/P. …"
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