Image 2_Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes.tif by Minzhen Deng (11267109)

“…Tetramethylpyrazine (TMP), a component of the Chinese medicine, was identified as a potential therapeutic agent. It significantly increased cell viability, reduced ET-1 expression, and mitigated OGD-induced astrocyte damage, as shown by in vitro experiments with ET-1 siRNA and cell lines overexpressing ET-1. …”

Data Sheet 1_Pinostilbene inhibits lung epithelial-mesenchymal transition and delays pulmonary fibrosis by modulating the PI3K/Akt pathway.docx by Xin Yu (124814)

“…Cellular experiments using A549 and Beas2B cells showed that PIN significantly reduced TGF-β1-induced mesenchymal marker expression while increasing epithelial marker expression. …”

Image 1_Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes.tif by Minzhen Deng (11267109)

“…Tetramethylpyrazine (TMP), a component of the Chinese medicine, was identified as a potential therapeutic agent. It significantly increased cell viability, reduced ET-1 expression, and mitigated OGD-induced astrocyte damage, as shown by in vitro experiments with ET-1 siRNA and cell lines overexpressing ET-1. …”

Unraveling Microplastic Effects on Gut Microbiota across Various Animals Using Machine Learning by Lingzi Yin (20477620)

“…Our study revealed that mice, compared with other animals, not only exhibit a heightened susceptibility to the toxic effects of microplasticsevidenced by decreased gut microbiota diversity, increased <i>Firmicutes</i>/<i>Bacteroidetes</i> ratios, destabilized microbial networks, and disruption in the equilibrium of beneficial and harmful bacteriabut also possess limited potential to degrade microplastics, unlike earthworms and insects. …”

Table_1_Differential microbiome features in lake–river systems of Taihu basin in response to water flow disturbance.xlsx by Peng Xiao (172430)

“…Additionally, migration and dispersal rates of microbes in the ET region, along with the impact of dispersal limitations, were significantly higher than in the ST region. High flow disturbances notably reduced microbial niche width and overlap, decreasing the complexity and stability of microbial coexistence networks. …”

Image_1_Differential microbiome features in lake–river systems of Taihu basin in response to water flow disturbance.pdf by Peng Xiao (172430)

“…Additionally, migration and dispersal rates of microbes in the ET region, along with the impact of dispersal limitations, were significantly higher than in the ST region. High flow disturbances notably reduced microbial niche width and overlap, decreasing the complexity and stability of microbial coexistence networks. …”

Image 1_Double-lumen tubes verus single-lumen tube in patients undergoing minimally invasive cardiac surgery: a randomised, controlled clinical trial.pdf by Zhenzhong Wang (407028)

“…</p>Conclusions<p>Two-lung ventilation with single-lumen tube is easy to perform, significantly increases oxygenation, and decreases the incidence of postoperative complications and airway injuries. …”

Data Sheet 1_N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder.pdf by Etna J. E. Engeli (20793524)

“…While N-acetylcysteine showed no impact on subjectively rated cocaine craving, neural cue reactivity in the superior frontal gyrus was significantly decreased under N-acetylcysteine compared to placebo.…”

Table 1_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.docx by Jikai He (11888466)

“…</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…”

Data Sheet 1_Gram-positive enhancer matrix delivering FVpE via M cell targeting elicit protective mucosal and adaptive immune responses against Helicobacter pylori infection.doc by Furui Zhang (3181935)

“…Finally, H. pylori-infected mice treated with GEM-SAM-FVpE can significantly reduce the colonization of H. pylori in gastric tissue while also decreasing gastric mucosal damage.…”

Table 2_Bacteroides ovatus-derived N-methylserotonin inhibit colorectal cancer via the HTR1D-mediated cAMP-PKA-NF-κB signaling axis.xlsx by Jikai He (11888466)

“…</p>Results<p>(1) CRC patients showed significantly increased metabolic pathways including glycolysis, methane metabolism, beneficial amino acid degradation, and linoleic acid degradation, along with significantly decreased B.o abundance and NMS levels, which were positively correlated; (2) NMS significantly inhibited CRC cell proliferation, migration, and invasion, while promoting apoptosis; (3) Combined treatment with B.o and orange fiber or NMS alone reduced tumorigenesis and improved intestinal barrier function; (4) Mechanistic studies revealed that these effects could be mediated through downregulation of 5-hydroxytryptamine receptor 1D (HTR1D) expression and inhibition of the cAMP/PKA/IκBα/NF-κB pathway; (5) The treatments optimized gut microbiota structure and metabolite composition.…”

Figure 3 from A Cost-Effective Two-Step Approach for Multi-Cancer Early Detection in High-Risk Populations by Shuaipeng Geng (20612220)

“…In the case–control cohort, the two-step MCED approach significantly improved specificity from 91.0% to 99.3%, whereas sensitivity decreased from 49.9% to 39.9%. …”

Data Sheet 1_The gastric microbiome altered by A4GNT deficiency in mice.zip by Dawei Gong (3070773)

“…The relative abundance of mutagenic Desulfovibrio and proinflammatory Prevotellamassilia in these mice was significantly increased, especially 4 weeks after birth. …”

Astaxanthin mediated repair of tBHP-Induced cellular injury in chondrocytes by Wenwei Liang (9286389)

“…In the osteoarthritis mouse model, they effectively decreased joint inflammation and increased the expression of chondrocyte markers.…”

The effect of G83R mutation on transthyretin protein structural stability by Xingwang Chen (11225802)

“…Molecular dynamics simulation suggested that the G83R mutation reduces the dynamic stability of TTR by increasing the molecule flexibility. In the thermodynamic stability, the quaternary and tertiary structural stability of TTR G83R is lower than wild-type TTR but significantly higher than TTR V30M. …”

Data Sheet 1_External and internal forcings controlled the precipitation patterns in eastern China over the past millennium.pdf by Hai Li (254910)

“…Our records indicate that the warm (cold) phase of the Atlantic Multidecadal Variability significantly increases (decreases) summer precipitation in North China through atmosphere-ocean feedback and circum-global teleconnection. …”

Table 1_External and internal forcings controlled the precipitation patterns in eastern China over the past millennium.xlsx by Hai Li (254910)

“…Our records indicate that the warm (cold) phase of the Atlantic Multidecadal Variability significantly increases (decreases) summer precipitation in North China through atmosphere-ocean feedback and circum-global teleconnection. …”

Data Sheet 1_Cellular respiration and amino acid metabolism is altered by dietary oligosaccharides in Salmonella with epithelial cell association.docx by Claire A. Shaw (22382332)

“…However, gene expression analysis revealed significantly induced expression of Specific Pathogenicity Island (SPI) 1 (adj. p < 2.0−6) and 2 (adj. p < 3.0−5) with HMO treatment, opposed to increased fimbriae expression (adj.p < 3.0−3) with MOS treatment. …”

Data Sheet 1_A glycogen derived from sea urchin-Strongylocentyotus internedius shifts macrophages to the M1 phenotype and enhances the anti-pancreatic cancer activity of gemcitabin... by Zhenzhen Deng (3707608)

“…MSGA-induced M1 macrophages decreased the cell viabilities and induced apoptosis of PDAC cells. …”

SPEED-ACCURACY TRADE-OFF PARADIGM IN COOPERATIVE TRANSPORT OF ANTS by N FC (19866297)

“…Regarding the efficiency estimators, we found that the consensus time decreases as the level of competition increases. Additionally, the ants exhibited more tortuous trajectories in all competitive scenarios compared to the distilled water control. …”