Data Sheet 1_Longitudinal changes in bodyweight, body condition, and muscle condition in ageing pet cats: findings from the Cat Prospective Ageing and Welfare Study.docx حسب Christine R. Pye (22118977)

"…All three metrics showed significant non-linear associations with age. Bodyweight increased slightly from age 7 to 10 (estimated marginal mean 4.77–4.82 kg) before decreasing to 4.30 kg by age 16 years. …"

Table 1_Astragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic.xlsx حسب Fengge Wang (4347442)

"…</p>Results<p>After the 25-day intervention, the GDM model + AS IV group showed significantly decreased fasting blood glucose levels (p = 0.0003), mean insulin levels (p = 0.0001), and insulin resistance index (p = 0.0001). …"

Table 2_Astragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic.xlsx حسب Fengge Wang (4347442)

"…</p>Results<p>After the 25-day intervention, the GDM model + AS IV group showed significantly decreased fasting blood glucose levels (p = 0.0003), mean insulin levels (p = 0.0001), and insulin resistance index (p = 0.0001). …"

Supplementary Material for: The impact of left ventricular structure and function on mortality in patients with aortic valve infective endocarditis treated with aortic valve replac... حسب figshare admin karger (2628495)

"…The mean LVEF was 54±11% preoperatively, decreasing to 51±11% postoperatively. …"

Data Sheet 2_Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus.docx حسب Haoyi Yang (8215116)

"…In particular, the increase in bile acid-related metabolites in the 2 mg BID group was significantly greater than that in the placebo group, and unsaturated fatty acid-related metabolites decreased in both the 2 mg BID group and the placebo group, but there was no significant difference between the two groups. …"

Table 1_Gut-to-tumor translocation of multidrug-resistant Klebsiella pneumoniae shapes the microbiome and chemoresistance in pancreatic cancer.docx حسب Lei Zhao (144153)

"…Comparative abundance analysis identified 59 differentially abundant microbial species in non-metastatic pancreatic cancer (NMPC) (56 increased, 3 decreased) and 21 in metastatic pancreatic cancer (MPC) (19 increased, 2 decreased), alongside 18 significantly altered microbial metabolic pathways (FDR-adjusted p < 0.05). …"

Data Sheet 1_Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus.docx حسب Haoyi Yang (8215116)

"…In particular, the increase in bile acid-related metabolites in the 2 mg BID group was significantly greater than that in the placebo group, and unsaturated fatty acid-related metabolites decreased in both the 2 mg BID group and the placebo group, but there was no significant difference between the two groups. …"

Data Sheet 1_Effect of environmentally relevant concentrations of estrogens on the aggressive response of male zebrafish.docx حسب Ying–Ying Zhang (21776942)

"…Post-exposure assays (mirror test and dyadic interaction) revealed that Mix significantly reduced the frequency of approaching mirror, the attack mirror duration, and the frequency of chasing un-exposed fish, indicating a decrease in aggressive behaviour in Mix-fish. …"

Table 1_Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.doc حسب Chanchan Xiao (9522614)

"…Notably, we discovered an S protein epitope, 67A>V, which demonstrated similar proportions of CD8 T-cell specificity between the ancestral and mutant strains, suggesting its conservation and potential immunogenicity for vaccine development. Furthermore, the third dose of the inactivated vaccine significantly increased the number of epitope-specific CD8 T cells, underscoring the importance of booster doses in enhancing cellular immune responses against the Omicron variant.…"

Table 1_Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis.xlsx حسب Lei Xiang (528500)

"…Introduction<p>Oxyresveratrol (ORes) exhibits significant anticancer activity, particularly against breast cancer. …"

Data_Sheet_1_Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.CSV حسب Ming-Jie Jia (18267391)

"…</p>Results<p>The IVW method revealed that the inflammatory proteins IFN-γ (p-value = 0.037, OR = 1.396, 95% CI = 1.020–1.910) and CCL7 (p-value = 0.033, OR = 1.294, 95% CI = 1.021–1.641) were associated with an increased risk of PCOS, while IL-6 (p-value = 0.015, OR = 0.678, 95% CI = 0.495–0.929) and MMP-10 (p-value = 0.025, OR = 0.753, 95% CI = 0.587–0.967) were associated with a decreased risk. No significant evidence suggested an effect of genetically predicted PCOS on inflammatory proteins. …"

Data_Sheet_2_Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.CSV حسب Ming-Jie Jia (18267391)

"…</p>Results<p>The IVW method revealed that the inflammatory proteins IFN-γ (p-value = 0.037, OR = 1.396, 95% CI = 1.020–1.910) and CCL7 (p-value = 0.033, OR = 1.294, 95% CI = 1.021–1.641) were associated with an increased risk of PCOS, while IL-6 (p-value = 0.015, OR = 0.678, 95% CI = 0.495–0.929) and MMP-10 (p-value = 0.025, OR = 0.753, 95% CI = 0.587–0.967) were associated with a decreased risk. No significant evidence suggested an effect of genetically predicted PCOS on inflammatory proteins. …"

Data Sheet 1_Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis.pdf حسب Lei Xiang (528500)

"…Introduction<p>Oxyresveratrol (ORes) exhibits significant anticancer activity, particularly against breast cancer. …"

Supplementary file 1_Hydroxysafflor yellow A alleviates oxidative stress and inflammatory damage in the livers of mice with nonalcoholic fatty liver disease and modulates gut micro... حسب Liang Wu (131111)

"…</p>Results<p>HSYA significantly inhibited HFD-induced weight gain and alleviated liver inflammation. …"

Image1_Oleic acid attenuates asthma pathogenesis via Th1/Th2 immune cell modulation, TLR3/4-NF-κB-related inflammation suppression, and intrinsic apoptotic pathway induction.tif حسب Soon-Young Lee (4721136)

"…The incidence is expected to increase as the average life expectancy increases, highlighting asthma as a significant health challenge in an aging society. The etiology of asthma is linked to an imbalance of Th1 and Th2 cells, respiratory inflammation, and pulmonary cell proliferation. …"

Association of COL4A2 indel polymorphism with the development of stomach adenocarcinoma in Chinese populations حسب Huihai Shi (19754499)

"…Logistic regression analysis revealed that both the heterozygote and homozygote 4-bp del/del genotypes were significantly associated with a decreased risk of STAD, even after controlling for other variables (adjusted odds ratio [OR] = 0.663, 95% confidence interval [CI] 0.519–0.848, <i>p</i> = 0.037; OR = 0.422, 95% CI 0.290–0.614, <i>p</i> = 0.000005, respectively). …"

Image 2_Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.tif حسب Chanchan Xiao (9522614)

"…Notably, we discovered an S protein epitope, 67A>V, which demonstrated similar proportions of CD8 T-cell specificity between the ancestral and mutant strains, suggesting its conservation and potential immunogenicity for vaccine development. Furthermore, the third dose of the inactivated vaccine significantly increased the number of epitope-specific CD8 T cells, underscoring the importance of booster doses in enhancing cellular immune responses against the Omicron variant.…"

Image 1_Oral supplementation with Lactobacillus fermentum MC018 improves intestinal health, immune response, and growth performance of Zi geese infected with Escherichia coli XH197... حسب Yang Li (7082)

"…Introduction<p>Escherichia coli infection causes severe diarrhea, decreases growth performance, and increases mortality of poultry, which imposes a significant economic burden on the poultry industry and severely limits its growth.…"

Image 1_Ketogenic diet–induced changes in methylation status and neuropeptide signaling: relationships between S-adenosylmethionine (AdoMet), orexin-A, and metabolic health.pdf حسب Laura Mosca (704904)

"…Circulating AdoMet (−75.7%) and Orexin-A (−7.2%) levels also decreased significantly. AdoMet levels positively correlated with body weight, BMI, visceral adipose tissue, total cholesterol, fasting glycemia, triglycerides, HbA1c, and notably Orexin-A (R² = 0.3848, p < 0.0001).…"

Data Sheet 1_Therapeutic efficacy of a galactoglucan from Pleurotus citrinopileatus in constipation: modulation of aquaporin signaling and intestinal barrier.pdf حسب Yi Gao (112914)

"…The oral administration of PCP-g resulted in a significant reduction in constipation symptoms, as indicated by an increase in fecal water content, normalization of pellet formation, enhancement of total fecal mass, decreased latency to the first stool, and improved intestinal propulsion. …"