Beta cell function derived from routine clinical measures reports and predicts treatment response to immunotherapy in recent-onset type 1 diabetes. حسب Michelle So (400874)

"…Beta2 score, derived from fasting glucose, C-peptide, HbA1c and insulin dose at 12 weeks, was optimal for predicting QRS>0 following one year of treatment with baricitinib and the other immunotherapies (areas under receiver-operator curve 0.864 and 0.765 respectively). A 6.2% decrease in Beta2 score at week 12 predicted significant improvement in HbA1c (-0.6% or -6 mmol/mol) and insulin use (-0.26 units/kg/day) in combined data from the rituximab, abatacept and anti-thymocyte globulin trials.…"

Supplementary file 1_HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway.doc حسب Chelimuge Gong (22563287)

"…This activation of STAT3 was accompanied by a significant increase in the anti-apoptotic protein Bcl-2 and a decrease in pro-apoptotic Bax, alongside the suppression of the maladaptive factor HIF-1α. …"

Data Sheet 1_Near-infrared fluorescent nanoprobe enables noninvasive, longitudinal monitoring of graft outcome in RPE transplantation.pdf حسب Guanzhou Di (21287414)

"…Immunofluorescence analysis revealed a significant temporal increase in the proportion of macrophages with nanoprobe-labeled cells following transplantation. …"

Image 4_Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma.pdf حسب Youyi Wu (20786402)

"…</p>Results<p>The results revealed significant correlations between CD8+ T cell-related genes and immune-related pathways. …"

Image details. حسب Yanxu Liang (22227024)

"…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…"

Table 1_Assessing the impact of non-protein nitrogen or rumen undegradable protein supplementation on rumen bacterial diversity and ruminal fermentation in grazing steers during th... حسب Ana Veronica Lino Dias (3985688)

"…</p>Results<p>GLU supplementation significantly increased supplement intake (p < 0.05) and tended to decrease the intake of forage NDF. …"

Model of the consequences of Ctu1 deficiency in zebrafish, figured by Figdraw. حسب Yangziwei Yu (20460661)

"…Inactivation of the CTU complex leads to a thermosensitive decrease with aberrant development in the nematode and fission yeast [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0315854#pone.0315854.ref015" target="_blank">15</a>]. …"

Table 2_Global burden of low back pain and its attributable risk factors from 1990 to 2021: a comprehensive analysis from the global burden of disease study 2021.docx حسب Yue Li (102191)

"…Compared with 1990, although the ASIR and age-standardized disability-adjusted life years rate (ASDALYsR) decreased, absolute numbers increased significantly. …"

Data Sheet 2_Effects of therapeutic horsemanship on caregiver stress scores of children with autism.pdf حسب Danielle C. Barron (21634196)

"…</p>Results<p>We observed caregivers experienced a statistically significant decrease (p=0.03) in their stress levels over a single semester of TH participation demonstrated by a reduction in DASS-21 stress subcategory (pre intervention mean 12.77 (SD = 9.95), post-intervention mean 8.62 (SD = 10.98). …"

Model parameters. حسب Yanxu Liang (22227024)

"…The study shows that: (1) With the increase of unloading amplitude, there is an increase in the number of nascent cracks and a tendency to expand, which is caused by shear extension cracks; with the increase of unloading amplitude, there is a tendency for the microporosity to shift to the mesoporosity, and the mesoporosity has a tendency to shift to the macroporosity, and there is a decrease in the number of micropores as a whole, which indicates that there is almost no new pore sprouting. (2) When the unloading amplitude is less than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen increase slowly; when the unloading amplitude is more than 20MPa, with the increase of the unloading amplitude, the pore ratio and expansion rate of the specimen have a significant tendency to increase. (3) With the increase of unloading amplitude, the shale shear strength limit value decreases more slowly, the modulus of elasticity and shear strength also show a similar pattern of change, and the same way to derive the rock Poisson’s ratio does not change much.…"

Image 4_Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials... حسب Virginie Piffaut (22399978)

"…</p>Results<p>While ascorbic acid did not exhibit any efficacy versus its vehicle in limiting skin hyperpigmentation induced by HEV, the use of 2-MNG (0.5 or 1%) led to an early significant decrease in HEV-induced pigmentation, which was sustained until the end of the study, as evidenced by colorimetry and significantly scored by visual assessment. …"

DataSheet1_OsPDIL1-5: dual role in promoting growth and development while modulating drought stress tolerance in rice (Oryza sativa L.).docx حسب Jilin Chen (19847928)

"…This discovery highlights the importance of GDDT as a pleiotropic gene with significant implications for both plant growth and drought resistance. …"

Ketamine wash-in. حسب Anne S. Fleiner (20496284)

"…(ii) The change in post-burst spiking after the wash-in of 20 μM and 100 μM was not significant compared to the control (MWU test). However, the decrease in post-burst spiking was significantly larger after the wash-in of 100 μM ketamine than with 20 μM (MWU test). …"

Table 4_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.docx حسب Ana Virseda-Berdices (9638081)

"…Ten and five of these upregulated genes were classified into two significantly enriched KEGG pathways: cell cycle and progesterone-mediated oocyte maturation (q-value <0.05), respectively. …"

Image 3_Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials... حسب Virginie Piffaut (22399978)

"…</p>Results<p>While ascorbic acid did not exhibit any efficacy versus its vehicle in limiting skin hyperpigmentation induced by HEV, the use of 2-MNG (0.5 or 1%) led to an early significant decrease in HEV-induced pigmentation, which was sustained until the end of the study, as evidenced by colorimetry and significantly scored by visual assessment. …"

Image 5_Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma.pdf حسب Youyi Wu (20786402)

"…</p>Results<p>The results revealed significant correlations between CD8+ T cell-related genes and immune-related pathways. …"

Table 2_Global patterns and health impact of unintentional injuries among children and adolescents, 1990–2021.docx حسب Wei Wei (21173)

"…Among the five socio-demographic index (SDI) regions, the low-middle SDI region exhibited the most significant decrease in injury incidence. Regionally, from 1990 to 2021, the Caribbean experienced the largest relative increase in injury incidence (EAPC 0.25, 95% CI: −0.60 to 1.11). …"

Table1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.docx حسب Xiaozhen Huang (5858690)

"…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…"

Table3_Causal relationship between antihypertensive drugs and Hashimoto’s thyroiditis: a drug-target Mendelian randomization study.xlsx حسب Bing Cui (179696)

"…Moreover, genetically mimicking the use of loop diuretics (OR [95% CI]: 0.94 [0.91, 0.97]; p = 3.57×10^-5) and thiazide diuretics (0.98 [0.96, 0.99]; p = 3.83×10^-3) showed a significant association with a decreased risk of HT only in European population. …"

Table 1_Association between eating behavior patterns and the therapeutic efficacy of GLP-1 receptor agonists in individuals with type 2 diabetes: a multicenter prospective observat... حسب Yuya Koide (22261300)

"…</p>Results<p>GLP-1RA therapy significantly reduced HbA1c, body weight, and body fat percentage at 12 months. …"