Table2_Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990–2019): an age-period-cohort analysis of the global burden of disease... by Juan Tang (437969)

“…Age effects across all countries and genders demonstrated an increasing trend over time, indicating age as a significant risk factor for IHD. Moreover, period and cohort effects in higher SDI countries exhibited a more rapid decline in both genders compared to lower SDI countries. …”

Data Sheet 1_Association of oxidative balance score with all-cause and cardiovascular mortality among patients with cardio-renal-metabolic disease.docx by Yucui Lin (21598376)

“…Moreover, Higher OBS quartiles were linked to a decreased risk of cardiovascular mortality, while no significant reduction was observed in the lower quartiles [model 3: Q2, Q3, Q4: aHR (95CI%) = 0.96(0.77–1.19), 0.78 (0.63–0.97), 0.70 (0.53–0.93), respectively; P for trend = 0.003]. …”

Table1_Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990–2019): an age-period-cohort analysis of the global burden of disease... by Juan Tang (437969)

“…Age effects across all countries and genders demonstrated an increasing trend over time, indicating age as a significant risk factor for IHD. Moreover, period and cohort effects in higher SDI countries exhibited a more rapid decline in both genders compared to lower SDI countries. …”

Causal associations between gut <i>Bifidobacteriaceae</i> and transplant failure: a Mendelian randomization study by Han Yan (126662)

“…</p> <p>Mendelian randomization studies have shown that a lower abundance of Bifidobacteriaceae in the gut could increase the risk of transplant failure.…”

Data Sheet 1_IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection.pdf by Rafaella Oliveira dos Santos (21710366)

“…Introduction<p>Malaria remains a significant public health challenge in Brazil, where Plasmodium vivax (P. vivax) is the predominant species. …”

 'Plan-B':  Impact of changes in the global funding landscape for Hepatitis B clinical and research programmes by marion delphin (13249479)

“…Respondents were mostly researchers / academics (34%) and healthcare workers (32%), with lower representation from people with lived experience of HBV (10%) or representing civil society organizations (10%). …”

Datasheet1_Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990–2019): an age-period-cohort analysis of the global burden of dis... by Juan Tang (437969)

“…Age effects across all countries and genders demonstrated an increasing trend over time, indicating age as a significant risk factor for IHD. Moreover, period and cohort effects in higher SDI countries exhibited a more rapid decline in both genders compared to lower SDI countries. …”

Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study by Zixiao Wang (6078317)

“…</p> <p>COA3, NFU1, and SARS2 significantly affect DPN risk, with COA3 lowering and NFU1 and SARS2 increasing risk. …”

Image 3_Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes.tif by Minzhen Deng (11267109)

“…In the MCAO animal model, TMP improved neurological scores, decreased infarct size, and lowered ET-1 levels, thus strengthening the blood-brain barrier and reducing oxidative stress. …”

Image 2_Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes.tif by Minzhen Deng (11267109)

“…In the MCAO animal model, TMP improved neurological scores, decreased infarct size, and lowered ET-1 levels, thus strengthening the blood-brain barrier and reducing oxidative stress. …”

Image 1_Tetramethylpyrazine attenuates the blood-brain barrier damage against ischemic stroke by targeting endothelin-1/Akt pathway in astrocytes.tif by Minzhen Deng (11267109)

“…In the MCAO animal model, TMP improved neurological scores, decreased infarct size, and lowered ET-1 levels, thus strengthening the blood-brain barrier and reducing oxidative stress. …”

The protective effects of neferine against paracetamol-induced liver injury are associated with the activation of SIRT1/Nrf2/HO-1 signaling pathway and inhibition of NF-kappa B/TNF... by Mohammed A. Altowijri (22461945)

“…<p>Drug-induced hepatotoxicity is a significant public health issue that influences the development of novel pharmaceutical therapies and the retraction of numerous promising medications from the market. …”

Table 1_Correlation between lactate/albumin ratio and 28-day mortality in sepsis-associated acute kidney injury patients.docx by Susu He (10361615)

“…The Kaplan–Meier curves showed that participants having elevated LAR exhibited significantly decreased survival rates. Cox proportional hazards models showed that higher LAR was related to higher 28-day death rate in SA-AKI patients (HR: 1.224, 95% CI: 1.160–1.291, p < 0.001). …”

Data_Sheet_1_The association between Geriatric Nutritional Risk Index and KSD disease: results from National Health and Nutrition Examination Survey 2007–2018.ZIP by Zhicheng Tang (7010534)

“…</p>Conclusion<p>The study underscores a significant, albeit nonlinear, association between elevated GNRI levels and decreased KSD prevalence. …”

Data_Sheet_1_The association between Geriatric Nutritional Risk Index and KSD disease: results from National Health and Nutrition Examination Survey 2007–2018.ZIP by Zhicheng Tang (7010534)

“…</p>Conclusion<p>The study underscores a significant, albeit nonlinear, association between elevated GNRI levels and decreased KSD prevalence. …”

DataSheet1_Updated evidence of the Naoshuantong capsule against ischemic stroke: a systematic review and meta-analysis of randomized controlled trials.docx by Cuilin Que (19743256)

“…Background<p>Stroke is a serious health issue that can result in death or disability, leading to a significant economic strain on society and families. …”

Data Sheet 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.xlsx by Demos Kynigopoulos (12420457)

“…</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”

Table 1_Case report: Treatment of severe phorate poisoning.xlsx by Wang Kunlun (21287522)

“…Phoratoxon sulfoxide has the highest concentration of these metabolites, followed by phoratoxon sulfone, phorate sulfone, phorate sulfoxide, and phoratoxon, respectively. HP treatment significantly lowered the serum levels of the toxic metabolites terminology. …”

Supplementary Material for: Supportive care for common conditions in small vulnerable newborns and term infants: the evidence by Jiang L. (4145290)

“…Kangaroo mother care (KMC) significantly reduced SVN’s mortality by discharge. Early erythropoiesis stimulating agent lowered SVN’s risk of receiving blood transfusion. …”

Supplementary file 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.docx by Demos Kynigopoulos (12420457)

“…</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”