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significant results » significant reductions (Expand Search), significant reduction (Expand Search)
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21201
Image 2_Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics.tif
Published 2025“…The KEGG enrichment analysis of serum and brain samples showed that amino acid metabolism pathways, such as tryptophan metabolism, threonine metabolism, serotonergic synapsis, methionine metabolism, and neuroactive ligand-receptor interaction, were significantly decreased in antibiotic-treated mice. Our study demonstrates that long-term antibiotic use induces gut dysbiosis and alters metabolic responses, leading to the dysregulation of brain signaling molecules and anxiety-like behavior. …”
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21202
Data Sheet 1_Consistent microbial responses during the aerobic thaw of Alaskan permafrost soils.docx
Published 2025“…Alpha diversity decreased with thaw across all sites, likely reflecting the increased dominance of specific thaw-responsive taxa that may be driving post-thaw biogeochemistry and increased respiration. …”
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21203
Data Sheet 1_Silencing ATF3 mediates mitochondrial homeostasis and improves ischemic stroke through regulating the MAPK signaling pathway.docx
Published 2025“…In stroke rats, silencing ATF3 reduced brain water content, decreased neurological injury and alleviated cerebral infarction. …”
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21204
Image 1_Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.jpeg
Published 2025“…Moreover, enforced GATA4 re-expression significantly counteracted the toxic effects of ATG5 on DOX-treated hearts. …”
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21205
Image 4_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.jpeg
Published 2024“…<p>Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one’s quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. …”
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21206
Comparison of 3D culture systems on mesenchymal stem cell longevity, regenerative potential, and secretome production
Published 2025“…LIF, OCT4, IGF1) were significantly higher in Bio-Block ASCs. Secretome protein declined 35%, 47%, and 10% in 2D, spheroid, and Matrigel, respectively, but was preserved in Bio-Blocks. …”
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21207
Table 6_Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles.xls
Published 2025“…Anagen-phase SHFs exhibit significantly increased volume, deeper dermal penetration, and active cell proliferation. …”
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21208
Table 2_Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles.pdf
Published 2025“…Anagen-phase SHFs exhibit significantly increased volume, deeper dermal penetration, and active cell proliferation. …”
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21209
Table 5_Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles.csv
Published 2025“…Anagen-phase SHFs exhibit significantly increased volume, deeper dermal penetration, and active cell proliferation. …”
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21210
Integrated bioinformatic and experimental study links cyclin B1/B2 to poor prognosis and immune infiltration in endometrial cancer
Published 2025“…High CCNB1/CCNB2 expression was significantly associated with shorter survival in EC patients. …”
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21211
Table 3_Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles.pdf
Published 2025“…Anagen-phase SHFs exhibit significantly increased volume, deeper dermal penetration, and active cell proliferation. …”
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21212
Table 4_Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles.csv
Published 2025“…Anagen-phase SHFs exhibit significantly increased volume, deeper dermal penetration, and active cell proliferation. …”
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21213
Table 1_Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles.pdf
Published 2025“…Anagen-phase SHFs exhibit significantly increased volume, deeper dermal penetration, and active cell proliferation. …”
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21214
White-to-opaque switching frequencies of double TF heterozygotes in a <i>WOR1</i>(KR-to-G) strain background.
Published 2025“…Double heterozygote strains that exhibited switching frequencies that were significantly higher than their expected switching frequencies (positive interactions) are shown in red and those significantly lower (negative interactions) are shown in blue (based on multiplying the switching frequencies of the corresponding single heterozygotes).…”
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21215
RipU<sup>K60</sup> impacts actin cytoskeleton organization at 48 hours post infiltration.
Published 2024“…(G,H) RipU<sup>K60</sup> significantly increased actin filament density (G), and decreased actin bundling (H) compared to controls at 48 hpi. …”
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21216
Table1_Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1.xlsx
Published 2024“…Muscle mass, the percentage of slow oxidative fibers, succinic dehydrogenase activity, muscle endurance, glucose tolerance, and the expression of the MyHC1 and MyHC2a genes increased while MyHC2b expression, lactate dehydrogenase activity, and the percentage of glycolytic muscle fibers decreased in SDSS-treated mice. Mechanistically, SDSS bound to the pyruvate kinase PKM1 and significantly repressed its activity. …”
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21217
Minimal data sets.
Published 2025“…Moreover, GW4869 (SMase inhibitor) and evogliptin significantly reduced SMase activity in sphingomyelin (SM)-induced VSMCs as compared to both P<sub>i</sub> and SM only-treated groups. …”
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21218
Numerical data underlying the graphs.
Published 2025“…MITF and c-MYC, key melanoma transcription factors, regulate human <i>DANCR</i> expression and melanoma patients with high <i>DANCR</i> display significantly decreased survival. <i>DANCR</i> is a melanoma oncogene that controls cancer-associated gene expression networks to promote human melanoma cell proliferation and migration. …”
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21219
Punicalagin ameliorates lipopolysaccharide-induced inflammatory response in dental pulp cells via inhibition of the NF-κB/Wnt5a-ROR2 pathway
Published 2025“…</p> <p></p> <p>This schematic illustration demonstrates that PCG ameliorates LPS-elicited pulpitis by decreasing the expression of the proteins associated with the NF-κB signaling pathway and its downstream Wnt5a/ROR2 pathway and by reducing the production of inflammatory molecules.…”
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21220
The analgesic effect of total saponins of Tribulus terrestris on neuropathic pain was studied based on TLR4/NF-κB pathway
Published 2025“…ELISA was employed to detect levels of IL-1β, IL-6, and TNF-ɑ in spinal cord. CCI significantly decreased PMWT and TL. In CCI neurons and glial cells in the spinal dorsal horn were deeply stained with swelling and atrophy observed. …”